The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hyaluronan in wound healing: Rediscovering a major player
Open accessAbstract
Wound healing involves a series of carefully modulated steps, from initial injury and blood clot to the final reconstituted tissue or scar. A dynamic reciprocity exists throughout between the wound, blood elements, extracellular matrix, and cells that participate in healing. Multiple cytokines and signal transduction pathways regulate these reactions. A major component throughout most of the process is hyaluronan, a straight‐chain carbohydrate extracellular matrix polymer. Hyaluronan occurs in multiple forms, chain length being the only distinguishing characteristic between them. Levels of hyaluronan in its high–molecular‐weight form are prominent in the earliest stages of wound repair. Progressively more fragmented forms occur in a manner not previously appreciated. We outline here steps in the wound healing cascade in which hyaluronan participates, as well as providing a review of its metabolism. Although described by necessity in a series of quantum steps, the healing process is constituted by a smooth continuum of overlapping reactions. The prevalence of hyaluronan in the wound (initially termed “hexosamine‐containing mucopolysaccharide”), particularly in its early stages, was pointed out over half a century ago by the H arvard surgeon J. E ngelbert D unphy. It appears we are now returning to where we started.
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Cites
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
Jiang, D., Liang, J., Fan, J., Yu, S., Chen, S., Luo, Y., Prestwich, G. D., Mascarenhas, M. M., Garg, H. G., Quinn, D. A., et al. (2005) · Nature Medicine · doi:10.1038/nm1315 · Cited by 1,401
Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4
Termeer, C., Benedix, F., Sleeman, J., Fieber, C., Voith, U., Ahrens, T., Miyake, K., Freudenberg, M., Galanos, C., & Simon, J. C. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20001858 · Cited by 1,378
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M., Shinomura, T., Hamaguchi, M., Yoshida, Y., Ohnuki, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25085 · Cited by 901
Hyaluronan in Tissue Injury and Repair
Jiang, D., Liang, J., & Noble, P. W. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123337 · Cited by 835
Hyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4
Taylor, K. R., Trowbridge, J. M., Rudisill, J. A., Termeer, C. C., Simon, J. C., & Gallo, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310859200 · Cited by 545
Slevin, M., Kumar, S., & Gaffney, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109443200 · Cited by 346
Ascorbic acid stimulates production of glycosaminoglycans in cultured fibroblasts
Kao, J., Huey, G., Kao, R., & Stern, R. (1990) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(90)90020-e · Cited by 39
Cited by
The bioink: A comprehensive review on bioprintable materials
Hospodiuk, M., Dey, M., Sosnoski, D., & Ozbolat, I. T. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.006 · Cited by 1,118
Vasvani, S., Kulkarni, P., & Rawtani, D. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.066 · Cited by 473
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
Tavianatou, A. G., Caon, I., Franchi, M., Piperigkou, Z., Galesso, D., & Karamanos, N. K. (2019) · The FEBS Journal · doi:10.1111/febs.14777 · Cited by 462
Implementing TIMERS: the race against hard-to-heal wounds
Atkin, L., Bućko, Z., Montero, E. C., Cutting, K., Moffatt, C., Probst, A., Romanelli, M., Schultz, G. S., & Tettelbach, W. (2019) · Journal of Wound Care · doi:10.12968/jowc.2019.28.sup3a.s1 · Cited by 369
Proteoglycan Chemical Diversity Drives Multifunctional Cell Regulation and Therapeutics
Karamanos, N. K., Piperigkou, Z., Theocharis, A. D., Watanabe, H., Franchi, M., Baud, S., Brézillon, S., Götte, M., Passi, A., Vigetti, D., et al. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00354 · Cited by 367
Metadata
- Authors
- Aya, K. L., & Stern, R.
- Venue
- Wound Repair and Regeneration
- Publisher
- Wiley
- Published
- 2014-09
- Volume
- 22
- Issue
- 5
- Pages
- 579-593
- ISSN
- 1067-1927 (ISSN-L)
- 1524-475X
- OpenAlex
- W1582833462
- Cited by
- 317
- References
- 9
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
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