Time‐of‐day variation in vascular function
Open accessAbstract
New Findings: What is the topic of this review? This report looks at the role of endothelial nitric oxide signalling in the time‐of‐day variation in vasoconstriction of resistance vessels. What advances does it highlight? It highlights a time‐of‐day variation in contraction of mesenteric arteries, characterized by a reduced contractile response to either phenylephrine or high K+ and increased relaxation in response to acetylcholine during the active period. This time‐of‐day variation in contraction results from a difference in endothelial nitric oxide synthase (eNOS) signalling that correlates with levels of eNOS expression, which peak during the active period and may have far reaching physiological consequences beyond regulation of blood pressure. There is a strong time‐of‐day variation in the vasoconstriction in response to sympathetic stimulation that may contribute to the time‐of‐day variation in blood pressure, which is characterized by a dip in blood pressure during the individual's rest period when sympathetic activity is low. Vasoconstriction is known to be regulated tightly by nitric oxide signalling from the endothelial cells, so we have looked at the effect of time‐of‐day on levels of endothelial nitric oxide synthase (eNOS) and vascular contractility. Mesenteric arteries isolated from the nocturnal rat exhibit a time‐of‐day variation in their contractile response to α 1‐adrenoreceptor and muscarinic activation, which is characterized by a reduced vasoconstriction in response to phenylephrine and enhanced vasodilatation in response to acetylcholine during the rat's active period at night. An increase in eNOS signalling during the active period is responsible for this time‐of‐day difference in response to phenylephrine and acetylcholine and correlates with the large increase in eNOS expression (mRNA and protein) during the active period, possibly driven by the presence of a functioning peripheral circadian clock. This increase in eNOS signalling may function to limit the increase in peripheral resistance and therefore blood pressure during the increased sympathetic activity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Candidate mechanisms for elevated cardiovascular disease risk due to shift work include disrupted 24-hour rhythms of blood pressure and vascular function, atherosclerosis, proinflammatory states, and altered lipid and glucose metabolism.
“Candidate mechanisms underlying elevated risk for CVD due to shift work include disrupted 24-hour rhythms of blood pressure [84] and vascular function [85], atherosclerosis [86], proinflammatory states [87], and altered lipid and glucose metabolism [88].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Circulating Nitrite Contributes to Cardioprotection by Remote Ischemic Preconditioning
Rassaf, T., Totzeck, M., Hendgen-Cotta, U. B., Shiva, S., Heusch, G., & Kelm, M. (2014) · Circulation Research · doi:10.1161/circresaha.114.303822 · Cited by 342 · see citing works
Hsieh, H., Liu, C.-A., Huang, B., Tseng, A. H.-H., & Wang, D. L. (2014) · Journal of Biomedical Science · doi:10.1186/1423-0127-21-3 · Cited by 333 · see citing works
Vascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 292 · see citing works
Mutation of the Circadian Clock Gene Per2 Alters Vascular Endothelial Function
Viswambharan, H., Carvas, J. M., Antic, V., Marecic, A., Jud, C., Zaugg, C. E., Ming, X., Montani, J., Albrecht, U., & Yang, Z. (2007) · Circulation · doi:10.1161/circulationaha.106.653303 · Cited by 242 · see citing works
Smooth-muscle BMAL1 participates in blood pressure circadian rhythm regulation
Xie, Z., Su, W., Liu, S., Zhao, G., Esser, K., Schroder, E. A., Lefta, M., Stauss, H. M., Guo, Z., & Gong, M. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci76881 · Cited by 189 · see citing works
Circadian Profile of Systemic Hemodynamics
Veerman, D. P., Imholz, B. P. M., Wieling, W., Wesseling, K. H., & van Montfrans, G. A. (1995) · Hypertension · doi:10.1161/01.hyp.26.1.55 · Cited by 176 · see citing works
Trochu, J., Leblais, V., Rautureau, Y., et al. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702797 · Cited by 167 · see citing works
Dessy, C., Moniotte, S., Ghisdal, P., et al. (2004) · Circulation · doi:10.1161/01.cir.0000139331.85766.af · Cited by 166 · see citing works
Alterations of the Circadian Clock in the Heart by Streptozotocin-induced Diabetes
Young, M. E., Wilson, C. R., Razeghi, P., Guthrie, P. H., & Taegtmeyer, H. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1504 · Cited by 165 · see citing works
Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta
Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.-M., Price, T. S., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2005) · Circulation · doi:10.1161/circulationaha.105.568626 · Cited by 157 · see citing works
Lemmer, B. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.008 · Cited by 129 · see citing works
Peripheral Circadian Clocks in the Vasculature
Reilly, D. F., Westgate, E. J., & FitzGerald, G. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144923 · Cited by 115 · see citing works
Characteristics of 24 h Telemetered Blood Pressure in eNOS‐Knockout and C57Bl/6J Control Mice
Vliet, B. N. V., Chafe, L. L., & Montani, J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041897 · Cited by 110 · see citing works
Circadian blood pressure and heart rate rhythms in mice
Li, P., Sur, S. H., Mistlberger, R. E., et al. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.2.r500 · Cited by 101 · see citing works
Suprachiasmatic lesions eliminate 24-h blood pressure variability in rats
Janssen, B. J., Tyssen, C. M., Duindam, H., & Rietveld, W. J. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90138-4 · Cited by 85 · see citing works
Su, W., Xie, Z., Guo, Z., Duncan, M. J., Lutshumba, J., & Gong, M. C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00825.2011 · Cited by 78 · see citing works
Mutoh, T., Shibata, S., Korf, H., & Okamura, H. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.028001 · Cited by 70 · see citing works
Twenty-four-hour blood pressure and heart rate profiles in humans. A twin study.
Degaute, J. P., Cauter, E. V., van de Borne, P., & Linkowski, P. (1994) · Hypertension · doi:10.1161/01.hyp.23.2.244 · Cited by 68 · see citing works
Briones, A. M., Daly, C. J., Jiménez‐Altayó, F., et al. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706369 · Cited by 66 · see citing works
Kung, T. A., Egbejimi, O., Cui, J., Ha, N. P., Durgan, D. J., Essop, M. F., Bray, M. S., Shaw, C. A., Hardin, P. E., Stanley, W. C., et al. (2007) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2007.08.018 · Cited by 62 · see citing works
Hemodynamic monitoring for 24 h in unanesthetized rats
Smith, T. L., Coleman, T. G., Stanek, K. A., & Murphy, W. R. C. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.6.h1335 · Cited by 54 · see citing works
Collins, H. E., & Rodrigo, G. C. (2010) · Circulation Research · doi:10.1161/circresaha.109.213942 · Cited by 50 · see citing works
Self-citationLoufrani, L., Retailleau, K., Bocquet, A., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00966.2006 · Cited by 48 · see citing works
Saito, T., Hirano, M., Ide, T., Ichiki, T., Koibuchi, N., Sunagawa, K., & Hirano, K. (2012) · Circulation · doi:10.1161/circulationaha.112.135608 · Cited by 41 · see citing works
Denniff, M. J., Turrell, H. E., Vanezis, A., & Rodrigo, G. C. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.11.009 · Cited by 34 · see citing works
Self-citationArraj, M., & Lemmer, B. (2007) · Chronobiology International · doi:10.1080/07420520701795357 · Cited by 17 · see citing works
Witte, K. K., Hasenberg, T., Rueff, T., Hauptfleisch, S., Schilling, L., & Lemmer, B. (2001) · Chronobiology International · doi:10.1081/cbi-100106080 · Cited by 16 · see citing works
Collins, H. E., Turrell, H. E., Samani, N. J., & Rodrigo, G. C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328360ae4b · Cited by 15 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being
James, S. M., Honn, K. A., Gaddameedhi, S., & Van Dongen, H. P. A. (2017) · Current Sleep Medicine Reports · doi:10.1007/s40675-017-0071-6 · Cited by 517 · see citing works
- Authors
- Rodrigo, G. C., & Denniff, M.
- Affiliations
- University of Leicester (GB)
- Corresponding author
- Rodrigo, G. C.
- Venue
- Experimental Physiology
- Publisher
- Wiley
- Published
- 2016-07-30
- Volume
- 101
- Issue
- 8
- Pages
- 1030-1034
- ISSN
- 0958-0670 (ISSN-L)
- 1469-445X
- OpenAlex
- W2504673739
- Cited by
- 16
- References
- 28
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Experimental Physiology (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by-nc-nd)
- Leicester Research Archive (University of Leicester) (submittedVersion, cc-by-nc-nd)
- Funders
- University of Leicester
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- circadian rhythm, diurnal variation, endothelial nitric oxide synthase, nitric oxide signaling, vascular contractility, mesenteric arteries, vasoconstriction, vasodilation, acetylcholine, phenylephrine, alpha1-adrenoceptors, muscarinic receptors, sympathetic activity, blood pressure, peripheral circadian clock
- MeSH terms
- Animals, Blood Pressure, Endothelium, Vascular, Humans, Mesenteric Arteries, Vasoconstriction, Signal Transduction, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
