Bioinformatic Analysis of Circadian Gene Oscillation in Mouse Aorta
Open accessAbstract
Background— Circadian rhythmicity of many aspects of cardiovascular function—blood pressure, coagulation and contractile function—is well established, as is diurnal variation in important clinical events, such as myocardial infarction and stroke. Here, we undertake studies to globally assess circadian gene expression in murine aorta. Methods and Results— Aortae from mice were harvested at 4-hour intervals for 2 circadian cycles (48 hours). Gene expression was assessed by expression profiling and subjected to a gene ontology bioinformatics analysis. Three hundred thirty transcripts exhibited a circadian pattern of oscillation in mouse aorta, including those intrinsic to the function of the molecular clock. In addition, many genes relevant to protein folding, protein degradation, glucose and lipid metabolism, adipocyte maturation, vascular integrity, and the response to injury are also included in this subset of roughly 7000 genes screened for circadian oscillation. Conclusions— Detection of functional cassettes of vascular genes that exhibit circadian regulation in the mouse will facilitate elucidation of the mechanisms by which the molecular clock may interact with environmental variables to modulate cardiovascular function and the response to therapeutic interventions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Approximately 5% of all genes in the aorta are rhythmic.
“For example, approximately 5% of all genes in the aorta are rhythmic (68).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [68]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new look at the statistical model identification
Akaike, H. (1974) · IEEE Transactions on Automatic Control · doi:10.1109/tac.1974.1100705 · Cited by 51,879 · see citing works
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works
Self-citationA Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001 · see citing works
Identifying biological themes within lists of genes with EASE
Hosack, D. A., Dennis, G., Sherman, B. T., Lane, H. C., & Lempicki, R. A. (2003) · Genome biology · doi:10.1186/gb-2003-4-10-r70 · Cited by 1,950 · see citing works
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907 · see citing works
Nonlinear Mixed Effects Models for Repeated Measures Data
Lindstrom, M. J., & Bates, D. M. (1990) · Biometrics · doi:10.2307/2532087 · Cited by 1,793 · see citing works
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works
Interacting molecular loops in the mammalian circadian clock
Shearman, L. P., Sriram, S., Weaver, D. R., Maywood, E. S., Chaves, I., Zheng, B., Kume, K., Lee, C. C., van der, G. T. J., Horst, et al. (2000) · Science · doi:10.1126/science.288.5468.1013 · Cited by 1,367 · see citing works
Circadian variation of blood-pressure
Millar-Craig, M., Bishop, C., & Raftery, E. B. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92998-7 · Cited by 1,293 · see citing works
Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Matsuo, T., Yamaguchi, S., Mitsui, S., Emi, A., Shimoda, F., & Okamura, H. (2003) · Science · doi:10.1126/science.1086271 · Cited by 1,132 · see citing works
Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works
Self-citationCircadian rhythms from flies to human
Panda, S., Hogenesch, J. B., & Kay, S. A. (2002) · Nature · doi:10.1038/417329a · Cited by 1,044 · see citing works
Self-citationCircadian Gene Expression in Individual Fibroblasts
Nagoshi, E., Saini, C., Bauer, C. R., Laroche, T., Naef, F., & Schibler, U. (2004) · Cell · doi:10.1016/j.cell.2004.11.015 · Cited by 1,003 · see citing works
MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts
Tapscott, S. J., Davis, R. L., Thayer, M. J., Cheng, P.-F., Weintraub, H. M., & Lassar, A. B. (1988) · Science · doi:10.1126/science.3175662 · Cited by 845 · see citing works
Hogenesch, J. B., Gu, Y.-Z., Jain, S. R., & Bradfield, C. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5474 · Cited by 781 · see citing works
Self-citationAkhtar, R. A., Reddy, A. B., Maywood, E. S., Clayton, J. D., King, V. M., Smith, A. G., Gant, T. W., Hastings, M. H., & Kyriacou, C. P. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00759-5 · Cited by 777 · see citing works
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
Davis, R. L., Cheng, P.-F., Lassar, A. B., & Weintraub, H. (1990) · Cell · doi:10.1016/0092-8674(90)90088-v · Cited by 765 · see citing works
Periadventitial fat releases a vascular relaxing factor
Löhn, M., Dubrovska, G., Lauterbach, B., Luft, F. C., Gollasch, M., & Sharma, A. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0024com · Cited by 474 · see citing works
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 441 · see citing works
Self-citationAntagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanismPreprint
Mitsui, S., Yamaguchi, S., Matsuo, T., Ishida, Y., & Okamura, H. (2001) · Genes & Development · doi:10.1101/gad.873501 · Cited by 403 · see citing works
GOToolBox: functional analysis of gene datasets based on Gene Ontology
Martin, D. P., Brun, C., Rémy, É., Mouren, P., Thieffry, D., & Jacq, B. (2004) · Genome biology · doi:10.1186/gb-2004-5-12-r101 · Cited by 387 · see citing works
Influence of Perivascular Adipose Tissue on Rat Aortic Smooth Muscle Responsiveness
Soltis, E. E., & Cassis, L. A. (1991) · Clinical and Experimental Hypertension · doi:10.3109/10641969109042063 · Cited by 382 · see citing works
Circadian Clock Mutation Disrupts Estrous Cyclicity and Maintenance of Pregnancy
Miller, B. H., Olson, S. L., Turek, F. W., Levine, J. E., Horton, T. H., & Takahashi, J. S. (2004) · Current Biology · doi:10.1016/j.cub.2004.07.055 · Cited by 377 · see citing works
The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
Vicent, D., Ilany, J., Kondo, T., Naruse, K., Fisher, S. J., Kisanuki, Y. Y., Bursell, S. E., Yanagisawa, M., King, G. L., & Kahn, C. R. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15211 · Cited by 355 · see citing works
Genome-wide Expression Analysis of Mouse Liver Reveals CLOCK-regulated Circadian Output Genes
Oishi, K., Miyazaki, K., Kadota, K., Kikuno, R. F., Nagase, T., Atsumi, G.-I., Ohkura, N., Azama, T., Mesaki, M., Yukimasa, S., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304564200 · Cited by 341 · see citing works
Gettys, T. W., Harkness, P. J., & Watson, P. M. (1996) · Endocrinology · doi:10.1210/endo.137.9.8756584 · Cited by 249 · see citing works
Chan, J. L., Blüher, S., Yiannakouris, N., Suchard, M. A., Kratzsch, J., & Mantzoros, C. S. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2105 · Cited by 242 · see citing works
Minokoshi, Y., Kahn, C. R., & Kahn, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.r300019200 · Cited by 219 · see citing works
MacDougald, O. A., Cornelius, P. K., Liu, R., & Lane, M. D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.2.647 · Cited by 156 · see citing works
Kita, Y., Shiozawa, M., Weihong, J., Majewski, R. R., Besharse, J. C., Greene, A. S., & Jacob, H. J. (2002) · Pharmacogenetics · doi:10.1097/00008571-200201000-00008 · Cited by 152 · see citing works
Transgenic rescue of insulin receptor–deficient mice
Okamoto, H., Nakae, J., Kitamura, T., Park, B.-C., Dragatsis, I., & Accili, D. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421645 · Cited by 151 · see citing works
Berk, P. D., Zhou, S., Kiang, C. L., Stump, D. D., Bradbury, M., & Isola, L. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8830 · Cited by 141 · see citing works
Straume, M. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)83007-6 · Cited by 137 · see citing works
Cutolo, M., SERIOLO, B., Craviotto, C., Pizzorni, C., & Sulli, A. (2003) · Annals of the Rheumatic Diseases · doi:10.1136/ard.62.7.593 · Cited by 135 · see citing works
Identification of a novel vertebrate circadian clock-regulated gene encoding the protein nocturnin
Green, C. B., & Besharse, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14884 · Cited by 134 · see citing works
Smolensky, M. H., Tatar, S. E., Bergman, S. A., Losman, J. G., Barnard, C. N., Dacso, C. C., & Kraft, I. A. (1976) · PubMed · Cited by 119 · see citing works
Mechanisms by Which Liver-Specific PEPCK Knockout Mice Preserve Euglycemia During Starvation
She, P., Burgess, S. C., Shiota, M., Flakoll, P. J., Donahue, E. P., Malloy, C. R., Sherry, A. D., & Magnuson, M. A. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1649 · Cited by 112 · see citing works
Circadian rhythm of baroreflex reactivity and adrenergic vascular response
Hossmann, V., FitzGerald, G. A., & Dollery, C. T. (1980) · Cardiovascular Research · doi:10.1093/cvr/14.3.125 · Cited by 92 · see citing works
Self-citationLee, Y. H., Alberta, J. A., Gonzalez, F. J., & Waxman, D. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36679-6 · Cited by 84 · see citing works
Regulation of the murine adipocyte fatty acid transporter gene by insulin
Man, M. Z., Hui, T. Y., Schaffer, J. E., Lodish, H. F., & Bernlohr, D. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.8.8843418 · Cited by 76 · see citing works
Circadian rhythm in experimental granulomatous inflammation is modulated by melatonin
Lopes, C., deLyra, J. L., Markus, R. P., & Mariano, M. (1997) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1997.tb00338.x · Cited by 72 · see citing works
Circadian rhythm in airway responsiveness and airway tone in patients with mild asthma
Bonnet, R., Jörres, R. A., Heitmann, U., & MAGNUSSEN, H. (1991) · Journal of Applied Physiology · doi:10.1152/jappl.1991.71.4.1598 · Cited by 60 · see citing works
Molecular and Statistical Tools for Circadian Transcript Profiling
Wijnen, H., Naef, F., & Young, M. W. (2005) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(05)93015-2 · Cited by 56 · see citing works
Marquez, S., Crespo, P. M., Carlini, V. P., Garbarino‐Pico, E., Baler, R., Caputto, B. L., & Guido, M. E. (2004) · The FASEB Journal · doi:10.1096/fj.03-0417fje · Cited by 41 · see citing works
Mounier, C., Chen, W., Klautky, S. A., & Goodridge, A. G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23606 · Cited by 27 · see citing works
Circadian variation of carrageenan-paw edema in the rat
Labrecque, G., Doré, F., & Bélanger, P.-M. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90406-9 · Cited by 24 · see citing works
Chronobiological studies on the blood-brain barrier
Mato, M., Ookawara, S., TOOYAMA, K., & Ishizaki, T. (1981) · Cellular and Molecular Life Sciences · doi:10.1007/bf01971811 · Cited by 14 · see citing works
Effect of time of day and rabbit strain on patterns of aortic wall permeability
Staughton, T. J., & Weinberg, P. D. (2003) · Experimental Physiology · doi:10.1113/expphysiol.2003.002635 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Scheiermann, C., Gibbs, J. E., Ince, L. M., & Loudon, A. S. I. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0008-4 · Cited by 558 · see citing works
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548 · see citing works
Circadian Rhythms and Metabolic Syndrome
Maury, E., Ramsey, K. M., & Bass, J. T. (2010) · Circulation Research · doi:10.1161/circresaha.109.208355 · Cited by 502 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Circadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works
Self-citationTime-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases
Chaix, A., Manoogian, E. N. C., Melkani, G. C., & Panda, S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124320 · Cited by 402 · see citing works
Self-citationInterplay of Circadian Clocks and Metabolic Rhythms
Wijnen, H., & Young, M. W. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090603 · Cited by 335 · see citing works
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 333 · see citing works
Ruben, M. D., Wu, G., Smith, D. F., Schmidt, R. E., Francey, L. J., Lee, Y. Y., Anafi, R. C., & Hogenesch, J. B. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat8806 · Cited by 314 · see citing works
Self-citationVascular Disease in Mice With a Dysfunctional Circadian Clock
Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 292 · see citing works
Self-citationCircadian Clocks and Metabolism
Marcheva, B., Ramsey, K. M., Peek, C. B., Affinati, A., Maury, E., & Bass, J. (2013) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-25950-0_6 · Cited by 282 · see citing works
Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1
Wang, N., Yang, G., Jia, Z., Zhang, H. E., Aoyagi, T., Soodvilai, S., Symons, J. D., Schnermann, J. B., Gonzalez, F. J., Litwin, S. E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.009 · Cited by 240 · see citing works
Melatonin and circadian biology in human cardiovascular disease
Domínguez‐Rodríguez, A., Abreu-González, P., Sanchez-Sanchez, J. J., Kaski, J. C., & Reiter, R. J. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00773.x · Cited by 232 · see citing works
Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
Yu, E. A., & Weaver, D. R. (2011) · Aging · doi:10.18632/aging.100323 · Cited by 228 · see citing works
Systems Biology of Mammalian Circadian Clocks
Ukai, H., & Ueda, H. R. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-073109-130051 · Cited by 195 · see citing works
Circadian Clocks and Vascular Function
Paschos, G. K., & FitzGerald, G. A. (2010) · Circulation Research · doi:10.1161/circresaha.109.211706 · Cited by 190 · see citing works
Self-citationRev-erb-α: an integrator of circadian rhythms and metabolism
Duez, H., & Staels, B. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00570.2009 · Cited by 175 · see citing works
Time‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155 · see citing works
Self-citationGenetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo
Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.739227 · Cited by 155 · see citing works
Self-citationCircadian Influence on Metabolism and Inflammation in Atherosclerosis
McAlpine, C. S., & Świrski, F. K. (2016) · Circulation Research · doi:10.1161/circresaha.116.308034 · Cited by 138 · see citing works
Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology
Martino, T. A., & Young, M. E. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730415575246 · Cited by 133 · see citing works
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism
Duez, H., & Staels, B. (2008) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2008.0014 · Cited by 132 · see citing works
Young, M. E., & Bray, M. S. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.12.010 · Cited by 129 · see citing works
Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells
Takeda, N., Maemura, K., Horie, S., Oishi, K., Imai, Y., Harada, T., Saito, T., Shiga, T., Amiya, E., Manabe, I., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705692200 · Cited by 129 · see citing works
Martino, T. A., & Sole, M. J. (2009) · Circulation Research · doi:10.1161/circresaha.109.206201 · Cited by 124 · see citing works
Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice
Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.261750 · Cited by 122 · see citing works
Self-citationHypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice
Su, W., Guo, Z., Randall, D. C., Cassis, L. A., Brown, D. R., & Gong, M. C. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00257.2008 · Cited by 118 · see citing works
Peripheral Circadian Clocks in the Vasculature
Reilly, D. F., Westgate, E. J., & FitzGerald, G. A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.144923 · Cited by 115 · see citing works
Self-citationInference of Gene Regulatory Networks Using Time-Series Data: A Survey
Chao Sima, A., Jianping Hua, A., & Jung, S. (2009) · Current Genomics · doi:10.2174/138920209789177610 · Cited by 110 · see citing works
Chronobiological Influence Over Cardiovascular Function
Rana, S., Prabhu, S. D., & Young, M. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.313349 · Cited by 99 · see citing works
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S., Gong, M. C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19372 · Cited by 103 · see citing works
Self-citationJames, F. O., Boivin, D. B., Charbonneau, S., Bélanger, V., & Cermakian, N. (2007) · Chronobiology International · doi:10.1080/07420520701800736 · Cited by 90 · see citing works
KLF15 Establishes the Landscape of Diurnal Expression in the Heart
Zhang, L., Prosdocimo, D. A., Bai, X., Fu, C., Zhang, R., Campbell, F. E., Liao, X., Coller, J. M., & Jain, M. K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.038 · Cited by 89 · see citing works
Circadian networks in human embryonic stem cell‐derived cardiomyocytes
Dierickx, P., Vermunt, M. W., Muraro, M. J., Creyghton, M. P., Doevendans, P. A., van Oudenaarden, A., Geijsen, N., & Laake, L. W. V. (2017) · EMBO Reports · doi:10.15252/embr.201743897 · Cited by 85 · see citing works
The day/night proteome in the murine heart
Podobed, P. S., Pyle, W. G., Ackloo, S. Z., Alibhai, F. J., Tsimakouridze, E. V., Ratcliffe, W. F., Mackay, A., Simpson, J. A., Wright, D. C., Kirby, G. M., et al. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00011.2014 · Cited by 84 · see citing works
Bray, M. S., & Young, M. E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.214643 · Cited by 82 · see citing works
Identification of Eya3 and TAC1 as Long-Day Signals in the Sheep Pituitary
Dupré, S. M., Miedzinska, K., Duval, C., Yu, L., Goodman, R. L., Lincoln, G. A., Davis, J. R., McNeilly, A. S., Burt, D. W., & Loudon, A. S. I. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.066 · Cited by 82 · see citing works
Circadian regulation of metabolic homeostasis: causes and consequences
Young, M. E., & McGinnis, G. R. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s78946 · Cited by 80 · see citing works
Su, W., Xie, Z., Guo, Z., Duncan, M. J., Lutshumba, J., & Gong, M. C. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00825.2011 · Cited by 78 · see citing works
Circadian Clocks and Metabolism: Implications for Microbiome and Aging
Paschos, G. K., & FitzGerald, G. A. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.07.010 · Cited by 77 · see citing works
Self-citationTissue-intrinsic dysfunction of circadian clock confers transplant arteriosclerosis
Cheng, B., Anea, C. B., Yao, L., Chen, F., Patel, V. S., Merloiu, A. M., Pati, P., Caldwell, R. W., Fulton, D. J., & Rudic, R. D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112998108 · Cited by 76 · see citing works
Self-citationCircadian Control of Inflammatory Processes in Atherosclerosis and Its Complications
Steffens, S., Winter, C., Schloss, M. J., Hidalgo, A., Weber, C., & Soehnlein, O. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309374 · Cited by 75 · see citing works
Liu, N.-C., Lin, W., Kim, E., Collins, L. L., Lin, H., Yu, I.-C. I., Sparks, J. D., Chen, L., Lee, Y., & Chang, C. (2007) · Diabetes · doi:10.2337/db07-0359 · Cited by 74 · see citing works
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure
Faraci, F. M., & Scheer, F. A. J. L. (2024) · Circulation Research · doi:10.1161/circresaha.124.323515 · Cited by 80 · see citing works
Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1)
Chalmers, J. A., Martino, T. A., Tata, N., Ralph, M. R., Sole, M. J., & Belsham, D. D. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90572.2008 · Cited by 72 · see citing works
Clock genes and metabolic disease
Marcheva, B., Ramsey, K. M., Affinati, A. H., & Bass, J. T. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00698.2009 · Cited by 71 · see citing works
Per2 Mutation Recapitulates the Vascular Phenotype of Diabetes in the Retina and Bone Marrow
Bhatwadekar, A. D., Yan, Y., Qi, X., Thinschmidt, J. S., Neu, M. B., Calzi, S. L., Shaw, L. C., Dominiguez, J. M., Busik, J. V., Lee, C., et al. (2012) · Diabetes · doi:10.2337/db12-0172 · Cited by 69 · see citing works
Pressed for time: the circadian clock and hypertension
Rudic, R. D., & Fulton, D. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00661.2009 · Cited by 67 · see citing works
Self-citationKhaper, N., Bailey, C. D. C., Ghugre, N. R., Reitz, C. J., Awosanmi, Z., Waines, R., & Martino, T. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.006 · Cited by 66 · see citing works
Anea, C. B., Ali, M. I., Osmond, J. M., Sullivan, J. C., Stepp, D. W., Merloiu, A. M., & Rudic, R. D. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.214379 · Cited by 65 · see citing works
Self-citationSole, M. J., & Martino, T. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00426.2009 · Cited by 64 · see citing works
Working around the clock: circadian rhythms and skeletal muscle
Zhang, X., Dube, T. J., & Esser, K. A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00725.2009 · Cited by 64 · see citing works
Luciano, A. K., Zhou, W., Santana, J. M., Kyriakides, C., Velázquez, H., & Sessa, W. C. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000773 · Cited by 64 · see citing works
MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions
Schober, A., Blay, R. M., Maleki, S. S., Zahedi, F., Winklmaier, A. E., Kakar, M. Y., Baatsch, I. M., Zhu, M., Geißler, C., Fusco, A. E., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.051614 · Cited by 63 · see citing works
Transcriptome profiling in fast versus slow-growing rainbow trout across seasonal gradients
Danzmann, R. G., Kocmarek, A. L., Norman, J. D., Rexroad, C. E., & Palti, Y. (2016) · BMC Genomics · doi:10.1186/s12864-016-2363-5 · Cited by 63 · see citing works
Circadian Rhythms in Cardiovascular Metabolism
Lal, H., Verma, S. K., Wang, Y., Xie, M., & Young, M. E. (2024) · Circulation Research · doi:10.1161/circresaha.123.323520 · Cited by 62 · see citing works
Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure
Eckle, T. D. L. G., Bertazzo, J., Khatua, T. N., Tabatabaei, S. R. F., Bakhtiari, N. M., Walker, L. A., & Martino, T. A. (2024) · Circulation Research · doi:10.1161/circresaha.123.323522 · Cited by 55 · see citing works
Circadian clock and vascular disease
Takeda, N., & Maemura, K. (2010) · Hypertension Research · doi:10.1038/hr.2010.68 · Cited by 56 · see citing works
Hansen, J., Timmers, S., Moonen‐Kornips, E., Duez, H., Staels, B., Hesselink, M. K. C., & Schrauwen, P. (2016) · Scientific Reports · doi:10.1038/srep35047 · Cited by 54 · see citing works
Conditional Deletion of Bmal1 Accentuates Microvascular and Macrovascular Injury
Bhatwadekar, A. D., Beli, E., Diao, Y., Chen, J., Luo, Q., Alex, A., Caballero, S., Dominguez, J. M., Salazar, T. E., Busik, J. V., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.02.014 · Cited by 53 · see citing works
Central and peripheral clocks in cardiovascular and metabolic function
Curtis, A. M., & FitzGerald, G. A. (2006) · Annals of Medicine · doi:10.1080/07853890600995010 · Cited by 46 · see citing works
Self-citationRudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.109.853002 · Cited by 45 · see citing works
Self-citationCardiac Clocks and Preclinical Translation
Mistry, P., Duong, A., Kirshenbaum, L. A., & Martino, T. A. (2017) · Heart Failure Clinics · doi:10.1016/j.hfc.2017.05.002 · Cited by 45 · see citing works
Knitting Up the Raveled Sleave of Care
Yang, G., Paschos, G. K., Curtis, A. M., Musiek, E. S., McLoughlin, S. C., & FitzGerald, G. A. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3007225 · Cited by 45 · see citing works
Self-citationRegulation of vascular function and blood pressure by circadian variation in redox signalling
Rodrigo, G. C., & Herbert, K. E. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.381 · Cited by 44 · see citing works
Yang, S., Wang, K., Valladares, O., Hannenhalli, S. S., & Bućan, M. (2007) · Genome biology · doi:10.1186/gb-2007-8-11-r247 · Cited by 42 · see citing works
Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet
Jang, W. Y., Bae, K. B., Kim, S. H., Yu, D. H., Kim, H. J., Ji, Y. R., Park, S. J., Park, S. J., Kang, M., Jeong, J. I., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.094 · Cited by 43 · see citing works
Shanmugam, V., Wafi, A., Al-Taweel, N., & Büsselberg, D. (2013) · Journal of Local and Global Health Science · doi:10.5339/jlghs.2013.3 · Cited by 41 · see citing works
Circadian (De)regulation in Head and Neck Squamous Cell Carcinoma
Rahman, S., Pavelić, S. K., & Markova-Car, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112662 · Cited by 41 · see citing works
Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork
Hirota, T., Kon, N., Itagaki, T., Hoshina, N., Okano, T., & Fukada, Y. (2010) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01371.x · Cited by 39 · see citing works
Response of Peripheral Rhythms to the Timing of Food Intake
Hatori, M., & Panda, S. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2014.10.027 · Cited by 38 · see citing works
Self-citationMartino, T. A., Tata, N., Bjarnason, G. A., Straume, M., & Sole, M. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00183.2007 · Cited by 38 · see citing works
Beesley, S., Noguchi, T., & Welsh, D. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159618 · Cited by 37 · see citing works
Durgan, D. J., Crossland, R. F., & Bryan, R. M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16675879 · Cited by 35 · see citing works
Circadian influence on the microbiome improves heart failure outcomes
Mistry, P., Reitz, C. J., Khatua, T. N., Rasouli, M., Oliphant, K., Young, M. E., Allen‐Vercoe, E., & Martino, T. A. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.09.006 · Cited by 36 · see citing works
Possible contribution of chronobiology to cardiovascular health
Sato, M., Matsuo, T., Atmore, H., & Akashi, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00409 · Cited by 36 · see citing works
Time in Motion: The Molecular Clock Meets the Microbiome
Liang, X., Bushman, F. D., & FitzGerald, G. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.020 · Cited by 35 · see citing works
Self-citationDysregulation of CLOCK gene expression in hyperoxia-induced lung injury
Lagishetty, V., Parthasarathy, P. T., Phillips, O., Fukumoto, J., Cho, Y. S., Fukumoto, I., Bao, H., Cox, R., Galam, L., Lockey, R. F., et al. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00064.2013 · Cited by 33 · see citing works
Circadian‐mediated regulation of cardiometabolic disorders and aging with time‐restricted feeding
Roth, J. R., Varshney, S., de Moraes, R. C. M., & Melkani, G. C. (2023) · Obesity · doi:10.1002/oby.23664 · Cited by 33 · see citing works
Mammalian Circadian Clock: The Roles of Transcriptional Repression and Delay
Minami, Y., Ode, K. L., & Ueda, H. R. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_15 · Cited by 31 · see citing works
Shen, Y., Xu, L., Dong, Y., Zhou, M., Han, T., Lü, C., Tang, X., Lin, C., Qian, R., & Guo, D. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166450 · Cited by 31 · see citing works
Metabolic Cycles Are Linked to the Cardiovascular Diurnal Rhythm in Rats with Essential Hypertension
Cui, H., Kohsaka, A., Waki, H., Bhuiyan, M. E. R., Gouraud, S. S., & Maeda, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017339 · Cited by 29 · see citing works
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases
Cao, Y., & Wang, R.-H. (2017) · Aging and Disease · doi:10.14336/ad.2016.1101 · Cited by 28 · see citing works
Brito, L. C., Marin, T. C., Azevêdo, L. M., Rosa‐Silva, J. M., Shea, S. A., & Thosar, S. S. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210036 · Cited by 45 · see citing works
Circadian Effects on Vascular Immunopathologies
Zeng, Q., Oliva, V. M., Moro, M. Á., & Scheiermann, C. (2024) · Circulation Research · doi:10.1161/circresaha.123.323619 · Cited by 27 · see citing works
Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease
Li, M., Xin, H., Yuan, Y., Yang, X., Li, H., Tian, D., Zhang, H., Zhang, Z., Han, T.-L., Chen, Q., et al. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.721231 · Cited by 29 · see citing works
Sartor, F., Ferrero-Bordera, B., Haspel, J., Sperandio, M., Holloway, P. M., & Merrow, M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323518 · Cited by 16 · see citing works
Circadian clocks, obesity and cardiometabolic function
Scott, E. M. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12518 · Cited by 25 · see citing works
Doliba, N. M., Fenner, D., Zelent, B., Bass, J. T., Sarabu, R., & Matschinsky, F. M. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01652.x · Cited by 25 · see citing works
Zhang, Y., Duan, C., Yang, J., Chen, S., Liu, Q. L., Zhou, L., Huang, Z., Xu, Y., & Xu, G. (2018) · Biochemical Journal · doi:10.1042/bcj20180005 · Cited by 23 · see citing works
Liu, X., Xiao, W. H., Jiang, Y., Zou, L., Chen, F., Xiao, W., Zhang, X., Cao, Y., Xu, L., & Zhu, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5542815 · Cited by 23 · see citing works
Lidington, D., Wan, H., Dinh, D. D., Ng, C., & Bolz, S.-S. (2021) · Stroke · doi:10.1161/strokeaha.121.036950 · Cited by 21 · see citing works
Integration of metabolic and cardiovascular diurnal rhythms by circadian clock
Kohsaka, A., Waki, H., Cui, H., Gouraud, S. S., & Maeda, M. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej12-0057 · Cited by 21 · see citing works
Xu, C., Lü, C., Hua, L., Huiming, J., Yin, L., Chen, S., & Qian, R. (2009) · Canadian Journal of Cardiology · doi:10.1016/s0828-282x(09)70122-9 · Cited by 21 · see citing works
Running for time: circadian rhythms and melanoma
Markova-Car, E., Jurišić, D., Ilić, N., & Pavelić, S. K. (2014) · Tumor Biology · doi:10.1007/s13277-014-1904-2 · Cited by 20 · see citing works
Dawn simulation light: a potential cardiac events protector
Viola, A., Gabel, V., Chellappa, S. L., Schmidt, C., Hommes, V., Tobaldini, E., Montano, N., & Cajochen, C. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.016 · Cited by 20 · see citing works
Brito, L. C., Marin, T. C., Azevêdo, L. M., Rosa‐Silva, J. M., Shea, S. A., & Thosar, S. S. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00225.x · Cited by 19 · see citing works
Akashi, M., Matsumura, R., Matsuo, T., Kubo, Y., Komoda, H., & Node, K. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.034 · Cited by 19 · see citing works
Circadian and Diurnal Regulation of Cerebral Blood Flow
Webb, A. J. S., Klerman, E. B., & Mandeville, E. T. (2024) · Circulation Research · doi:10.1161/circresaha.123.323049 · Cited by 18 · see citing works
Li, M., Zhang, T., Jia, Y., Sun, Y., Zhang, S., Mi, P., Feng, Z., Zhao, X. J., Chen, D., & Feng, X. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125373 · Cited by 18 · see citing works
- Authors
- Rudic, R. D., McNamara, P., Reilly, D., Grosser, T., Curtis, A.-M., Price, T. S., Panda, S., Hogenesch, J. B., & FitzGerald, G. A.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Venue
- Circulation
- Published
- 2005-10-25
- Volume
- 112
- Issue
- 17
- Pages
- 2716-2724
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2160217837
- Cited by
- 157
- References
- 50
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 11 · 2023: 7 · 2022: 10 · 2021: 6 · 2020: 3 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 6
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Publikationen an der Universität Bielefeld (Universität Bielefeld) (submittedVersion)
- Funders
- American Heart Association
- University of Pennsylvania
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL54500, P50HL054500, HL62250, P01HL062250)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK070658, DK-70658)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, circadian gene expression, aorta, mice, molecular clock, cardiovascular function, Gene Ontology, vascular gene expression, glycolipid metabolism, vascular integrity, injury response, adipocyte maturation
- MeSH terms
- Animals, Aorta, Thoracic, Circadian Rhythm, Darkness, Gene Expression Regulation, Male, Mice, Inbred C57BL, Nucleic Acid Hybridization, Oscillometry, Transcription, Genetic, Polymerase Chain Reaction, Computational Biology, Oligonucleotide Array Sequence Analysis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
