The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function
Abstract
New Findings: What is the Topic of this review? This review describes new evidence for the control of pancreatic exocrine and endocrine secretion by the dorsal motor nucleus of the vagus. It describes the effects of several gastrointestinal peptides on pancreatic secretion and considers their sites of action in the vago‐vagal reflex pathway. What advances does it highlight? This review draws together recent electrophysiological, anatomical and pharmacological studies to provide a state‐of‐art view of the parasympathetic control of the exocrine and endocrine pancreas. Recent investigation of the factors and pathways that are involved in regulation of pancreatic secretory function (PSF) has led to development of a pancreatic vagovagal reflex model. This model consists of three elements, including pancreatic vagal afferents, the dorsal motor nucleus of the vagus (DMV) and pancreatic vagal efferents. The DMV has been recognized as a major component of this model and so this review focuses on the role of this nucleus in regulation of PSF. Classically, the control of the PSF has been viewed as being dependent on gastrointestinal hormones and vagovagal reflex pathways. However, recent studies have suggested that these two mechanisms act synergistically to mediate pancreatic secretion. The DMV is the major source of vagal motor output to the pancreas, and this output is modulated by various neurotransmitters and synaptic inputs from other central autonomic regulatory circuits, including the nucleus of the solitary tract. Endogenously occurring excitatory (glutamate) and inhibitory amino acids (GABA) have a marked influence on DMV vagal output to the pancreas. In addition, a variety of neurotransmitters and receptors for gastrointestinal peptides and hormones have been localized in the DMV, emphasizing the direct and indirect involvement of this nucleus in control of PSF.
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In the fasting and in the feeding situation, the vagus nerve is responsible for energy storage.
“Thus, in the fasting and in the feeding situation, the vagus nerve is responsible for energy storage.”
From Interaction of the endocrine system with inflammation: a function of energy and volume regulation (2014) · cites this paper as [40]
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Interaction of the endocrine system with inflammation: a function of energy and volume regulation
Straub, R. H. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4484 · Cited by 121 · see citing works
“In the fasting situation, vagal afferents are important in transferring hepatoportal information on low blood glucose and low levels of other nutrients to the dorsal vagal complex, leading to hunger signals, inhibition of sympathetic activation, inhibition of efferent vagal activation, hypometabolism, and hypothermia…”
BackgroundAcylated Ghrelin as a Multi-Targeted Therapy for Alzheimer's and Parkinson's Disease
Reich, N., & Hölscher, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.614828 · Cited by 48 · see citing works
“In concert, the area postrema, the nucleus tractus solitarius and the dorsal motor nucleus of the vagus (DMV) form the dorsal vagal complex (DVC) that serves as a commanding platform for the autonomic nervous system, navigating gastrointestinal motility, secretory activity and pancreatic hormone release (Price et al.,…”
Background
- Authors
- Mussa, B. M., & Verberne, A. J. M.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Experimental Physiology
- Publisher
- Wiley
- Published
- 2012-10-17
- Volume
- 98
- Issue
- 1
- Pages
- 25-37
- ISSN
- 0958-0670 (ISSN-L)
- 1469-445X
- OpenAlex
- W2131984129
- Cited by
- 68
- References
- 140
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 2
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- dorsal motor nucleus of the vagus, pancreatic secretion, exocrine pancreas, endocrine pancreas, vago-vagal reflex, gastrointestinal peptides, nucleus tractus solitarius, glutamate, GABA, parasympathetic modulation, neurotransmitters
- MeSH terms
- Insulin Secretion, Afferent Pathways, Cholecystokinin, Efferent Pathways, Humans, Insulin, Motor Neurons, Nitric Oxide, Pancreas, Pancreatic Polypeptide, Parasympathetic Nervous System, Reflex, Serotonin, Thyrotropin-Releasing Hormone, Vagus Nerve, Glucagon-Like Peptide 1, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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