Cited by 68Gastrointestinal motility and disordersPancreatic function and diabetesVagus Nerve Stimulation Research

The dorsal motor nucleus of the vagus and regulation of pancreatic secretory function

Mussa, Bashair M., Verberne, Anthony J. M.·2013·Experimental Physiology

Abstract

New Findings: What is the Topic of this review? This review describes new evidence for the control of pancreatic exocrine and endocrine secretion by the dorsal motor nucleus of the vagus. It describes the effects of several gastrointestinal peptides on pancreatic secretion and considers their sites of action in the vago‐vagal reflex pathway. What advances does it highlight? This review draws together recent electrophysiological, anatomical and pharmacological studies to provide a state‐of‐art view of the parasympathetic control of the exocrine and endocrine pancreas. Recent investigation of the factors and pathways that are involved in regulation of pancreatic secretory function (PSF) has led to development of a pancreatic vagovagal reflex model. This model consists of three elements, including pancreatic vagal afferents, the dorsal motor nucleus of the vagus (DMV) and pancreatic vagal efferents. The DMV has been recognized as a major component of this model and so this review focuses on the role of this nucleus in regulation of PSF. Classically, the control of the PSF has been viewed as being dependent on gastrointestinal hormones and vagovagal reflex pathways. However, recent studies have suggested that these two mechanisms act synergistically to mediate pancreatic secretion. The DMV is the major source of vagal motor output to the pancreas, and this output is modulated by various neurotransmitters and synaptic inputs from other central autonomic regulatory circuits, including the nucleus of the solitary tract. Endogenously occurring excitatory (glutamate) and inhibitory amino acids (GABA) have a marked influence on DMV vagal output to the pancreas. In addition, a variety of neurotransmitters and receptors for gastrointestinal peptides and hormones have been localized in the DMV, emphasizing the direct and indirect involvement of this nucleus in control of PSF.

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Crossref · 10.1113/expphysiol.2012.066472

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Authors
Mussa, B. M., & Verberne, A. J. M.
Affiliations
The University of Melbourne (AU)
Venue
Experimental Physiology
Publisher
Wiley
Published
2012-10-17
Volume
98
Issue
1
Pages
25-37
ISSN
  • 0958-0670 (ISSN-L)
  • 1469-445X
OpenAlex
W2131984129
Cited by
68
References
140
Citations by year
2026: 4 · 2025: 2 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 6 · 2013: 2
FWCI
0.78
Type
journal article
Language
en
Open access
closed
Locations
  • Experimental Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
dorsal motor nucleus of the vagus, pancreatic secretion, exocrine pancreas, endocrine pancreas, vago-vagal reflex, gastrointestinal peptides, nucleus tractus solitarius, glutamate, GABA, parasympathetic modulation, neurotransmitters
MeSH terms
Insulin Secretion, Afferent Pathways, Cholecystokinin, Efferent Pathways, Humans, Insulin, Motor Neurons, Nitric Oxide, Pancreas, Pancreatic Polypeptide, Parasympathetic Nervous System, Reflex, Serotonin, Thyrotropin-Releasing Hormone, Vagus Nerve, Glucagon-Like Peptide 1, Ghrelin

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