Cadherins: cellular adhesive molecules serving as signalling mediators
Open accessAbstract
The single pass, transmembrane proteins of the cadherin family have been appreciated as important proteins that regulate intercellular adhesion. In addition to this critical function, cadherins contribute to important signalling events that control cellular homeostasis. Many examples exist of classical, desmosomal and atypical cadherins participating in the regulation of signalling events that control homeostatic functions in cells. Much of the work on cadherin mediated signalling focuses on classical cadherins or on specific disease states such as pemphigus vulgaris. Cadherin mediated signalling has been shown to play critical roles during development, in proliferation, apoptosis, disease pathobiology and beyond. It is becoming increasingly clear that cadherins operate through a range of molecular mechanisms. The diversity of pathways and cellular functions regulated by cadherins suggests that we have only scratched the surface in terms of the roles that these versatile proteins play in signalling and cellular function. image
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Cadherins are a family of calcium-dependent transmembrane adhesion proteins that link β- and α-catenin to the actin cytoskeletal network and regulate cellular homeostasis through signaling mediating development, proliferation, apoptosis, and disease pathology.
“Cadherins are a family of calcium-dependent transmembrane adhesion proteins that link β- and α-catenin to the actin cytoskeletal network (Punovuori et al., 2021) and also regulate cellular homeostasis through signaling mediating development, proliferation, apoptosis, and disease pathology (Yulis et al., 2018).”
From APOE3 Christchurch modulates β-catenin/Wnt signaling in iPS cell-derived cerebral organoids from Alzheimer’s cases (2024) · cites this paper as Yulis et al., 2018
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Cadherins in early neural development
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- Authors
- Yulis, M., Kusters, D. H. M., & Nusrat, A.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Nusrat, Asma
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2018-08-08
- Volume
- 596
- Issue
- 17
- Pages
- 3883-3898
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC6117591
- OpenAlex
- W2890788959
- Cited by
- 60
- References
- 80
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 13 · 2022: 9 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Queen Mary, University of London (608765)
- National Institutes of Health (DK055679)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- cadherins, classical cadherins, desmosomal cadherins, atypical cadherin, cell adhesion, signal transduction, pemphigus vulgaris, desmosomes, apoptosis, cell proliferation, development (biology), disease pathobiology
- MeSH terms
- Animals, Cell Adhesion, Cell Differentiation, Humans, Neoplasms, Signal Transduction, Cadherins, Apoptosis
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