Turning fat into muscle: can this be an alternative to anti‐obesity drugs such as semaglutide?
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Bimagrumab effects in patients with obesity are preferable to those of semaglutide because the fat loss is not associated with muscle atrophy, as is the case with semaglutide treatment.
“In an opinion in the Journal of Physiology [209], we have recently argued that the bimagrumab effects in patients with obesity are preferable to those of, e.g., semaglutide because the fat loss is not associated with muscle atrophy, as is the case with semaglutide treatment [210].”
From Effects of Skeletal Muscle Hypertrophy on Fat Mass and Glucose Homeostasis in Humans and Animals: A Narrative Review with Systematic Literature Search (2025) · cites this paper as [209]
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- Authors
- Wackerhage, H., Hinrichs, A., Wolf, E., & Hrabě de Angelis, M.
- Affiliations
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
- German Center for Diabetes Research (DE)
- German Center for Diabetes Research (DZD) Neuherberg Germany
- Corresponding author
- Wackerhage, Henning
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2024-03
- Volume
- 602
- Issue
- 8
- Pages
- 1655-1658
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W4392354768
- Cited by
- 8
- References
- 18
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (TRR333, 450149205)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- adipose tissue browning, brown adipose tissue, anti-obesity drugs, semaglutide, obesity treatment, metabolic reprogramming
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Semaglutide, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Humans, Hypoglycemic Agents, Muscles, Anti-Obesity Agents
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