The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Glucose‐induced electrical activity in pancreatic islet cells
Open accessAbstract
1. Intracellular recording of the transmembrane potential in mouse pancreatic cells revealed a membrane potential of −20·1 ± 0·8 mV for islet cells and −41·2 ± 1·4 mV for acinar cells. 2. The membrane potential of islet cells was glucose dependent and in the absence of glucose the cells hyperpolarized to −32·7 mV; with glucose 27·7 m M they depolarized to −16·1 mV. 3. Above a threshold concentration of glucose (4 m M) small action potentials of amplitude 1‐4 mV were induced in islet cells. The percentage of cells impaled exhibiting action potentials reached a maximum of 80% at 27·7 m M glucose. 4. Mannose 16·6 m M was similar to glucose in its ability to induce action potential discharge in islet cells. 5. 2,4‐Dinitrophenol (0·25 m M) hyperpolarized islet cells and blocked electrical activity induced by glucose 11·1 m M. 6. Adrenaline (1 μ M) completely blocked glucose‐induced electrical activity but without altering the membrane potential. 7. The origin and functional significance of glucose‐induced electrical activity in islet cells is discussed in relation to insulin secretion.
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Citations
Cites
Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro
Coore, H., & Randle, P. (1964) · Biochemical Journal · doi:10.1042/bj0930066 · Cited by 540
A Receptor Mechanism for the Inhibition Of Insulin Release by Epinephrine in Man*
Porte, D. (1967) · Journal of Clinical Investigation · doi:10.1172/jci105514 · Cited by 398
Metabolism of Glucose in the Islets of Langerhans
Matschinsky, F. M., & Ellerman, J. E. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93432-0 · Cited by 310
Electrical Activity in Pancreatic Islet Cells
DEAN, P. M., & MATTHEWS, E. K. (1968) · Nature · doi:10.1038/219389a0 · Cited by 303
Self-citationElectrical activity in pancreatic islet cells: effect of ions
Dean, P. M., & Matthews, E. K. (1970) · The Journal of Physiology · doi:10.1113/jphysiol.1970.sp009208 · Cited by 195
Self-citationBeta Adrenergic Stimulation of Insulin Release in Man
Porte, D. (1967) · Diabetes · doi:10.2337/diab.16.3.150 · Cited by 194
Requirement for calcium ion in insulin secretion by the perfused rat pancreas
Curry, D., Bennett, L., & Grodsky, G. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.214.1.174 · Cited by 182
Cations and the secretion of insulin from rabbit pancreas in vitro
Hales, C. N., & Milner, R. D. G. (1968) · The Journal of Physiology · doi:10.1113/jphysiol.1968.sp008647 · Cited by 132
Pentitols and insulin release by isolated rat islets of Langerhans
MONTAGUE, W., & Taylor, K. W. (1968) · Biochemical Journal · doi:10.1042/bj1090333 · Cited by 107
Milner, R. D. G., & Hales, C. N. (1969) · Biochemical Journal · doi:10.1042/bj1130473 · Cited by 64
Cited by
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208
Insulin granule dynamics in pancreatic beta cells
Rorsman, P., & Renstr�m, E. (2003) · Diabetologia · doi:10.1007/s00125-003-1153-1 · Cited by 844
The cell biology of systemic insulin function
Tokarz, V. L., MacDonald, P. E., & Klip, A. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201802095 · Cited by 471
“…often causally related to insulin resistance, hypertension, and type 2 diabetes (Taniguchi et al., 2006; Hoehn et al., 2008; Odegaard and Chawla, 2013; Boucher et al., 2014; DeFronzo et al., 2015; Samuel and Shulman, 2016; Haeusler et al., 2018; also see other important highlights in the text box).”
BackgroundHenquin, J. C., & Meissner, H. P. (1984) · Experientia · doi:10.1007/bf01971450 · Cited by 324
Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
Schuit, F. C., In't Veld, P. A., & Pipeleers, D. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3865 · Cited by 308
Metadata
- Authors
- Dean, P. M., & Matthews, E. K.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1970-09
- Volume
- 210
- Issue
- 2
- Pages
- 255-264
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2160297786
- Cited by
- 363
- References
- 14
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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