Review lecture. Neurotransmitters and trophic factors in the autonomic nervous system.

Nerve growth factor.

Levi-Montalcini, R., & Angeletti, P. U. (1968) · Physiological Reviews · doi:10.1152/physrev.1968.48.3.534 · Cited by 2,016

Purinergic Nerves

Burnstock, G. (1972) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06930-3 · Cited by 1,852

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

PEARSE, A. G. E. (1969) · Journal of Histochemistry & Cytochemistry · doi:10.1177/17.5.303 · Cited by 1,673

The smooth muscle cell in culture

Chamley-Campbell, J., Campbell, G. R., & Ross, R. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.1.1 · Cited by 1,553

Peptidergic neurones

Hökfelt, T., Johansson, O., Ljungdahl, Å., Lundberg, J. M., & Schultzberg, M. (1980) · Nature · doi:10.1038/284515a0 · Cited by 1,547

The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1

Drury, A. N., & Szent-Györgyi, A. (1929) · The Journal of Physiology · doi:10.1113/jphysiol.1929.sp002608 · Cited by 1,487

Presynaptic regulation of catecholamine release

Langer, S. Z. (1974) · Biochemical Pharmacology · doi:10.1016/0006-2952(74)90187-7 · Cited by 1,142

Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

Hökfelt, T., Ljungdahl, Å., Steinbusch, H., Verhofstad, A., Nilsson, G., Brodin, E., Pernow, B., & Goldstein, M. (1978) · Neuroscience · doi:10.1016/0306-4522(78)90017-9 · Cited by 814

The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea‐pig ileum longitudinal muscle strip

PATON, W. D. M., & VIZI, E. S. (1969) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1969.tb07964.x · Cited by 704

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

BURNSTOCK, G., CAMPBELL, G., SATCHELL, D., & SMYTHE, A. (1970) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1970.tb10646.x · Cited by 697

Local regulation of adrenergic neurotransmission.

Westfall, T. C. (1977) · Physiological Reviews · doi:10.1152/physrev.1977.57.4.659 · Cited by 641

Do some nerve cells release more than one transmitter?

Burnstock, G. (1976) · Neuroscience · doi:10.1016/0306-4522(76)90054-3 · Cited by 639

The retrograde axonal transport of nerve growth factor

Hendry, I. A., Sto¨ckel, K., Thoenen, H., & Iversen, L. L. (1974) · Brain Research · doi:10.1016/0006-8993(74)90536-8 · Cited by 597

Types of nerves in the enteric nervous system

Furness, J. B., & Costa, M. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90067-6 · Cited by 568

Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non‐adrenergic inhibitory nerves in the gut

BURNSTOCK, G., CAMPBELL, G., SATCHELL, D., & SMYTHE, A. (1997) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1997.tb06815.x · Cited by 545

Occurrence of vasoactive intestinal polypeptide (VIP)-like immunoreactivity in certain cholinergic neurons of the cat: Evidence from combined immunohistochemistry and acetylcholinesterase staining

Lundberg, J. M., Hökfelt, T., Schultzberg, M., Uvnäs-Wallensten, K., Köhler, C., & Said, S. I. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90018-6 · Cited by 497

Serotonin and substance P coexist in neurons of the rat's central nervous system

Chan-Palay, V., Jonsson, G., & Palay, S. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.3.1582 · Cited by 486

Occurrence of somatostatin-like immunoreactivity in some peripheral sympathetic noradrenergic neurons

Hökfelt, T., Elfvin, L. G., Elde, R., Schultzberg, M., Goldstein, M., & Luft, R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3587 · Cited by 464

In Vitro Experiments on the Effects of Mouse Sarcomas 180 and 37 on the Spinal and Sympathetic Ganglia of the Chick Embryo

Levi-Montalcini, R., Meyer, H., & Hamburger, V. (1997) · World Scientific Series in 20th Century Biology · doi:10.1142/9789812830319_0007 · Cited by 446

Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: evidence for cholinergic, adrenergic, and dual-function neurons.

Furshpan, E. J., MacLeish, P. R., O'Lague, P. H., & Potter, D. D. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.11.4225 · Cited by 432

Atropine resistant excitation of the urinary bladder: the possibility of transmission via nerves releasing a purine nucleotide

Burnstock, G., Dumsday, B., & Smythe, A. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb07283.x · Cited by 398

Presynaptic modulation of neurochemical transmission

VIZI, E. (1979) · Progress in Neurobiology · doi:10.1016/0301-0082(79)90011-x · Cited by 378

EVOLUTION OF THE AUTONOMIC INNERVATION OF VISCERAL AND CARDIOVASCULAR SYSTEMS IN VERTEBRATES

BURNSTOCK, G. (1969) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06875-9 · Cited by 366

VAGAL AND SYMPATHETIC EFFECTS ON THE PACEMAKER FIBERS IN THE SINUS VENOSUS OF THE HEART

Hutter, O. F., & Trautwein, W. (1956) · The Journal of General Physiology · doi:10.1085/jgp.39.5.715 · Cited by 364

Apamin blocks certain neurotransmitter-induced increases in potassium permeability

Banks, B. E. C., Brown, C., Burgess, G. M., Burnstock, G., Claret, M., Cocks, T. M., & Jenkinson, D. H. (1979) · Nature · doi:10.1038/282415a0 · Cited by 354

Enkephalin immunoreactive nerve fibres and cell bodies in sympathetic ganglia of the guinea-pig and rat

Schultzberg, M., Hökfelt, T., Terenius, L., Elfvin, L.-G., Lundberg, J. M., Brandt, J., Elde, R. P., & Goldstein, M. (1979) · Neuroscience · doi:10.1016/0306-4522(79)90087-3 · Cited by 344

On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals.

Silinsky, E. M. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp010925 · Cited by 333

Fine structure of the myenteric plexus in the guinea-pig ileum.

Gabella, G. (1972) · Europe PMC (PubMed Central) · Cited by 326

PURINERGIC INNERVATION OF THE GUINEA‐PIG URINARY BLADDER

BURNSTOCK, G., COCKS, T., CROWE, R., & KASAKOV, L. (1978) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1978.tb07782.x · Cited by 317

Selective Induction by Nerve Growth Factor of Tyrosine Hydroxylase and Dopamine-β-Hydroxylase in the Rat Superior Cervical Ganglia

Thoenen, H., Angeletti, P. U., Levi-Montalcini, R., & Kettler, R. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.7.1598 · Cited by 312

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

Hendry, I. A., & Campbell, J. (1976) · Journal of Neurocytology · doi:10.1007/bf01175120 · Cited by 309

The transmission of excitation from autonomic nerve to smooth muscle

Burnstock, G., & Holman, M. E. (1961) · The Journal of Physiology · doi:10.1113/jphysiol.1961.sp006617 · Cited by 289

Acetylcholine in Adrenergic Transmission

Burn, J. H., & Rand, M. J. (1965) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.05.040165.001115 · Cited by 275

The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine

Vizi, E. S., & Knoll, J. (1976) · Neuroscience · doi:10.1016/0306-4522(76)90132-9 · Cited by 256

The ultrastructure of Auerbach's plexus in the guinea-pig. I. Neuronal elements

Cook, R. D., & Burnstock, G. (1976) · Journal of Neurocytology · doi:10.1007/bf01181655 · Cited by 248

Serotonergic activation of tonic-type enteric neurons in guinea pig small bowel

Wood, J. D., & Mayer, C. J. (1979) · Journal of Neurophysiology · doi:10.1152/jn.1979.42.2.582 · Cited by 248

CORRELATION OF FINE STRUCTURE AND PHYSIOLOGY OF THE INNERVATION OF SMOOTH MUSCLE IN THE GUINEA PIG VAS DEFERENS

Merrillees, N. C. R., Burnstock, G., & Holman, M. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.19.3.529 · Cited by 231

An analysis of the responses of the isolated stomach to electrical stimulation and to drugs

Paton, W. D. M., & Vane, J. R. (1963) · The Journal of Physiology · doi:10.1113/jphysiol.1963.sp007040 · Cited by 218

Purinergic receptors

Burnstock, G. (1976) · Journal of Theoretical Biology · doi:10.1016/0022-5193(76)90133-8 · Cited by 207

Biological Sciences: Release of ATP from Rat Motor Nerve Terminals

Silinsky, E. M., & Hubbard, J. I. (1973) · Nature · doi:10.1038/243404a0 · Cited by 205

Inhibition of the Smooth Muscle of the Taenia Coli

BURNSTOCK, G., CAMPBELL, G., BENNETT, M., & HOLMAN, M. E. (1963) · Nature · doi:10.1038/200581a0 · Cited by 193

THE EFFECTS OF ADENOSINE TRIPHOSPHATE AND ADENOSINE DIPHOSPHATE ON TRANSMISSION AT THE RAT AND FROG NEUROMUSCULAR JUNCTIONS

RIBEIRO, J. A., & WALKER, J. (1975) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1975.tb06931.x · Cited by 192

A method for studying the effects of ions and drugs on the resting and action potentials in smooth muscle with external electrodes

Burnstock, G., & Straub, R. W. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp005924 · Cited by 190

The postjunctional effects and neural release of purine compounds in the guinea-pig vas deferens

Westfall, D. P., Stitzel, R. E., & Rowe, J. N. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90250-9 · Cited by 186

An analysis of excitatory junctional potentials recorded from arterioles.

Hirst, G. D. S., & Neild, T. O. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012374 · Cited by 171

Nature and Nurture in Development of the Autonomic Neuron

Bunge, R., Johnson, M., & Ross, C. D. (1978) · Science · doi:10.1126/science.24273 · Cited by 167

Ultrastructural localization of a new neuronal peptide (VIP)

Larsson, L. (1977) · Histochemistry and Cell Biology · doi:10.1007/bf00489676 · Cited by 157

Innervation of the guinea-pig taenia coli: Are there intrinsic inhibitory nerves which are distinct from sympathetic nerves?

Burnstock, G., Campbell, G. R., Bennett, M., & Holman, M. E. (1964) · International Journal of Neuropharmacology · doi:10.1016/0028-3908(64)90003-6 · Cited by 152

The nervous release and the action of substances which affect intestinal muscle through neither adrenoreceptors nor cholinoreceptors

Furness, J. B., & Costa, M. (1973) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1973.0015 · Cited by 138

Effect of sympathetic denervation on smooth muscle cell proliferation in the growing rabbit ear artery.

Bevan, R. D. (1975) · Circulation Research · doi:10.1161/01.res.37.1.14 · Cited by 135

On Inhibitory Fibres in the Vagus for the end of the Œsophagus and the Stomach

Langley, J. N. (1898) · The Journal of Physiology · doi:10.1113/jphysiol.1898.sp000737 · Cited by 131

Purinergic Receptors: Photoaffinity Analog of Adenosine Triphosphate Is a Specific Adenosine Triphosphate Antagonist

Hogaboom, G. K., O’Donnell, J. P., & Fedan, J. S. (1980) · Science · doi:10.1126/science.6103581 · Cited by 125

Modulation of the evoked release of noradrenaline in canine saphenous vein via presynaptic receptors for adenosine but not ATP

Mey, J. G. R. D., Burnstock, G., & Vanhoutte, P. M. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90115-8 · Cited by 119

A SENSITIVE RADIOIMMUNOASSAY FOR 7S NERVE GROWTH FACTOR ANTIGENS IN SERUM AND TISSUES

Johnson, D. G., Görden, P., & Kopin, I. J. (1971) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1971.tb00190.x · Cited by 112

Inhibition by Acetylcholine of Adrenergic Neurotransmission in Vascular Smooth Muscle

Vanhoutte, P. M. (1974) · Circulation Research · doi:10.1161/01.res.34.3.317 · Cited by 111

Possible involvement of a transmitter different from norepinephrine in the residual responses to nerve stimulation of the cat nictitating membrane after pretreatment with reserpine.

Langer, S. Z., & Pinto, J. E. B. (1976) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)30464-7 · Cited by 111

Growth Control of the Sympathetic System by a Specific Protein Factor

Levi‐Montalcini, R., & Angeletti, P. U. (1961) · The Quarterly Review of Biology · doi:10.1086/403331 · Cited by 109

Neural Nomenclature

Burnstock, G. (1971) · Nature · doi:10.1038/229282d0 · Cited by 104

Dedifferentiation, redifferentiation and bundle formation of smooth muscle cells in tissue culture : the influence of cell number and nerve fibres

Chamley, J. H., CAMPBELL, G. R., & Burnstock, G. (1974) · Development · doi:10.1242/dev.32.2.297 · Cited by 102

The action of adrenaline on excitability and membrane potential in the taenia coli of the guinea‐pig and the effect of DNP on this action and on the action of acetylcholine

Burnstock, G. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp006052 · Cited by 102

The effects of acetylcholine on membrane potential, spike frequency, conduction velocity and excitability in the taenia coli of the guinea‐pig

Burnstock, G. (1958) · The Journal of Physiology · doi:10.1113/jphysiol.1958.sp006051 · Cited by 85

DEMONSTRATION OF "GAP JUNCTIONS" BETWEEN SMOOTH MUSCLE CELLS

Uehara, Y., & Burnstock, G. (1970) · The Journal of Cell Biology · doi:10.1083/jcb.44.1.215 · Cited by 77

Effects of neuronal polypeptides on intestinal smooth muscle; a comparison with non-adrenergic, non-cholinergic nerve stimulation and ATP

Cocks, T. M., & Burnstock, G. (1979) · European Journal of Pharmacology · doi:10.1016/0014-2999(79)90084-0 · Cited by 68

Embryologic development of a mouse sympathetic ganglion in vivo and in vitro.

Coughlin, M. D., Boyer, D. M., & Black, I. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.8.3438 · Cited by 67

The electrical and mechanical responses of intestinal smooth muscle cells to stimulation of their extrinsic parasympathetic nerves

Gillespie, J. S. (1962) · The Journal of Physiology · doi:10.1113/jphysiol.1962.sp006915 · Cited by 65

Do some sympathetic neurones synthesize and release both noradrenaline and acetylcholine?

Burnstock, G. (1978) · Progress in Neurobiology · doi:10.1016/0301-0082(78)90013-8 · Cited by 62

Development of neurons synthesizing noradrenaline and acetylcholine in the superior cervical ganglion of the rat in vivo and in vitro

Hill, C. E., & Hendry, I. A. (1977) · Neuroscience · doi:10.1016/0306-4522(77)90027-6 · Cited by 56

Degeneration and regeneration of smooth muscle transplants in the anterior eye chamber: An ultrastructural study

CAMPBELL, G. R., Uehara, Y., Malmfors, T., & Burnstock, G. (1971) · Cell and Tissue Research · doi:10.1007/bf00330735 · Cited by 53

Interactions between autonomic nerves and smooth and cardiac muscle cells in tissue culture

Mark, G. E., Chamley, J. H., & Burnstock, G. (1973) · Developmental Biology · doi:10.1016/0012-1606(73)90231-5 · Cited by 45

Evolutionary Aspects of Transmitter Heterogeneity

Sakharov, D. A. (1974) · Springer eBooks · doi:10.1007/978-3-7091-8341-0_3 · Cited by 26

PEPTIDERGIC VERSUS PURINERGIC

Bloom, S. R., & Polak, J. M. (1978) · The Lancet · doi:10.1016/s0140-6736(78)90025-9 · Cited by 26

Modes of Vasoconstrictor and Vasodilator Neurotransmission

Su, C. (2008) · Blood Vessels · doi:10.1159/000158164 · Cited by 15

Proceedings: Does the giant cerebral neurone of Helix release two transmitters: ACh and serotonin?

Cottrell, G. A. (1976) · PubMed · Cited by 14

Morphological changes produced by drugs acting on the autonomic nervous system

Burnstock, G. (1979) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(79)90073-1 · Cited by 11

Comparative Studies on the Effects of Bradykinin and Vagal Stimulation on Motility in the Stomach and Colon

Fasth, S., Hultén, L., Jahnberg, T., & Martinson, J. (1975) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1975.tb05792.x · Cited by 10

Endogenous nitric oxide synthesis: Biological functions and pathophysiology

Bredt, D. S. (1999) · Free Radical Research · doi:10.1080/10715769900301161 · Cited by 796

Cerebral circulation and metabolism

Siesjö, B. K. (1984) · Journal of Neurosurgery · doi:10.3171/jns.1984.60.5.0883 · Cited by 585

The past, present and future of purine nucleotides as signalling molecules

Burnstock, G. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00125-1 · Cited by 543

Interstitial Cells of Cajal Mediate Cholinergic Neurotransmission from Enteric Motor Neurons

Ward, S. M., Beckett, E. A. H., Wang, X., Baker, F., Khoyi, M., & Sanders, K. M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01393.2000 · Cited by 436

Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate.

McIntyre, T. M., Zimmerman, G. A., Satoh, K., & Prescott, S. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111957 · Cited by 422