Cited by 746Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

Open access

Madison, D V, Nicoll, R A·1984·The Journal of Physiology

DOI 10.1113/jphysiol.1984.sp015378PMC PMC1193414

Open this paper in CoChat — free account

Abstract

Experiments using intracellular recording techniques were performed on rat hippocampal neurones in vitro, to study the discharge properties of these cells. When CA 1 pyramidal cells were excited by injecting long depolarizing current pulses (approximately 600‐800 ms), they responded with an initial rapid action potential discharge which slowed, or accommodated, and then stopped after 200‐300 ms. The train of action potentials was followed by a hyperpolarization which was due primarily to calcium‐activated potassium conductance (GK(Ca]. The amplitude of this hyperpolarization increased with an increasing number of action potentials in the initial discharge. Blocking the calcium‐activated potassium conductance, by injecting EGTA into the cell, by bathing the cell in cadmium, a calcium channel blocker, or by bathing the cell in calcium‐free medium, reduced the after‐hyperpolarization (a.h.p.) and accommodation such that the frequency of action potential discharge increased and the duration of this discharge was prolonged. Blocking the calcium‐activated potassium conductance had a greater effect on discharge frequency later in the action potential train, as late interspike intervals were shortened more than early ones by the application of cadmium or of calcium‐free medium. This was presumably because the calcium‐activated potassium conductance was more developed later in the train. Accommodation was not completely abolished in the absence of calcium and presence of cadmium, suggesting that other factors, in addition to calcium‐activated potassium conductance, contributed to this process. This remaining accommodation was reduced by low doses of carbachol, suggesting that the M‐current also plays a role in accommodation. We conclude that accommodation of the action potential discharge of hippocampal pyramidal cells may be regulated by at least two potassium currents: the calcium‐activated potassium current and the M‐current. Both of these currents are turned on during excitation of the neurone and act in an inhibitory manner on that neurone to limit further action potential discharge.

Integrity signals

Registry

Crossref · 10.1113/jphysiol.1984.sp015378

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,046
CALCIUM-DEPENDENT POTASSIUM ACTIVATION IN NERVOUS TISSUES
Meech, R. W. (1978) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.07.060178.000245 · Cited by 754
Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma
Connor, J. A., & Stevens, C. F. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009366 · Cited by 735
Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus
Madison, D. V., & Nicoll, R. A. (1982) · Nature · doi:10.1038/299636a0 · Cited by 581
Self-citation
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro
Alger, B. E., & Nicoll, R. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014255 · Cited by 528
Self-citation
Pharmacological inhibition of the M‐current
Adams, P. R., Brown, D. A., & Constanti, A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014411 · Cited by 431
Epileptiform Burst Afterhyperpolarization: Calcium-Dependent Potassium Potential in Hippocampal CA1 Pyramidal Cells
Alger, B. E., & Nicoll, R. A. (1980) · Science · doi:10.1126/science.7444438 · Cited by 421
Self-citation
Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells
Haas, H. L., & Konnerth, A. (1983) · Nature · doi:10.1038/302432a0 · Cited by 414
Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells
Cole, A. E., & Nicoll, R. A. (1983) · Science · doi:10.1126/science.6612345 · Cited by 374
Self-citation

Show all 35 references

Sorted by citations

Items 501–600 of 744

Metabolic Energy of Action Potentials Modulated by Spike Frequency Adaptation
Yi, G., Wang, J., Li, H., Wei, X., & Deng, B. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00534 · Cited by 15
Olfactory‐learning abilities are correlated with the rate by which intrinsic neuronal excitability is modulated in the piriform cortex
Cohen-Matsliah, S. I., Rosenblum, K., & Barkai, E. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06894.x · Cited by 15
Firing pattern of rat hippocampal neurons: A perforated patch clamp study
Podlogar, M., & Dietrich, D. (2006) · Brain Research · doi:10.1016/j.brainres.2006.02.050 · Cited by 15
Evidence of increased excitability in GEPR hippocampus preceding development of seizure susceptibility
Verma-Ahuja, S., Evans, M. S., & Espinosa, J. A. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00027-8 · Cited by 15
A computational model of visual marking using an inter-connected network of spiking neurons: The spiking search over time & space model (sSoTS)
Mavritsaki, E., Heinke, D. G., Humphreys, G. W., & Deco, G. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2006.09.003 · Cited by 15
In vivo kindling does not alter afterhyperpolarizations (AHPs) following action potential firing in vitro in basolateral amygdala neurons
Asprodini, E., Rainnie, D. G., Anderson, A., & Shinnick‐Gallagher, P. (1992) · Brain Research · doi:10.1016/0006-8993(92)91595-6 · Cited by 15
Conditioning-Specific Biophysical Alterations in Rabbit Hippocampus
Disterhoft, J. F., Coulter, D. A., & Alkon, D. L. (1988) · Springer eBooks · doi:10.1007/978-1-4757-9610-0_10 · Cited by 15
The cholinergic inhibition of afterhyperpolarization in rat hippocampus is independent of cAMP-dependent protein kinase
Blitzer, R. D., Wong, T., Nouranifar, R., & Landau, E. M. (1994) · Brain Research · doi:10.1016/0006-8993(94)90096-5 · Cited by 15
β3-Adrenergic receptor-dependent modulation of the medium afterhyperpolarization in rat hippocampal CA1 pyramidal neurons
Church, T. W., Brown, J. T., & Marrion, N. V. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00334.2018 · Cited by 19
Unusually Slow Spike Frequency Adaptation in Deep Cerebellar Nuclei Neurons Preserves Linear Transformations on the Subsecond Timescale
Khan, M. N., Wu, S., Chen, C. H., & Regehr, W. G. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1869-21.2022 · Cited by 14
Subthreshold Sodium Current Underlies Essential Functional Specializations at Primary Auditory Afferents
Curti, S., Gómez‐Sena, L., Budelli, R., & Pereda, A. E. (2008) · Journal of Neurophysiology · doi:10.1152/jn.01173.2007 · Cited by 14
Comparison of Properties of Medial Entorhinal Cortex Layer II Neurons in Two Anatomical Dimensions with and without Cholinergic Activation
Yoshida, M., Jochems, A., & Hasselmo, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073904 · Cited by 15
Metabotropic Actions of Kainate Receptors in the Regulation of IsAHP and Excitability in CA1 Pyramidal Cells
Melyan, Z., & Wheal, H. V. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9557-5_5 · Cited by 14
Gene therapy in rodent amygdala against fear disorders
Mitra, R., & Sapolsky, R. M. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2010.509341 · Cited by 14
Electrophysiological properties and their modulation by norepinephrine in the ambiguus neurons of the guinea pig
Nishimura, Y., Muramatsu, M., Asahara, T., Tanaka, T., & Yamamoto, T. (1995) · Brain Research · doi:10.1016/0006-8993(95)01058-4 · Cited by 14
Electrophysiological properties of neurons recorded intracellularly in slices of the pigeon optic tectum
Hardy, O., Audinat, É., & Jassik-Gerschenfeld, D. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90291-0 · Cited by 14
Tolbutamide blocks Ca2+- and voltage-dependent K+ currents of hippocampal Ca1 neurons
Erdemli, G., & Krnjević, K. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00124-0 · Cited by 14
Repetitive firing properties in subpopulations of the chick Edinger Westphal nucleus
Fujii, J. T. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160303 · Cited by 14
Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation
Satchell, M., Butel-Fry, E., Noureddine, Z., Simmons, A., Ognjanovski, N., Aton, S. J., & Żochowski, M. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013097 · Cited by 15
Perturbed Ca2+-dependent signaling of DYT2 hippocalcin mutant as mechanism of autosomal recessive dystonia
Osypenko, D., Dovgan, A. V., Kononenko, N. I., Dromaretsky, A., Matvieienko, M., Rybachuk, O. A., Zhang, J., Коrogod, S. М., Venkataraman, V., & Belan, P. V. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104529 · Cited by 14
Neural Mechanisms of Odor Rule Learning
Barkai, E. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63350-7.00010-3 · Cited by 14
Dentate Granule Cells Are Hyperexcitable in the TgF344-AD Rat Model of Alzheimer's Disease
Smith, L. A., Goodman, A. M., & McMahon, L. L. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.826601 · Cited by 12
Effects of quinidine and quinine on the excitability of pyramidal neurons in guinea-pig hippocampal slices
Yoshida, S., Fujimura, K., & Matsuda, Y. (1986) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00583380 · Cited by 13
Kainate Receptor-Mediated Modulation of Hippocampal Fast Spiking Interneurons in a Rat Model of Schizophrenia
Gisabella, B., Bolshakov, V. Y., & Benes, F. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032483 · Cited by 13
A Role of NMDA Receptors and Ca2+ Influx in Synaptic Plasticity in the Developing Visual Cortex
Tsumoto, T., Kimura, F., & Nishigori, A. (1990) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5769-8_20 · Cited by 13
Septal Modulation of Hippocampal Dynamics: What Is the Function of the Theta Rhythm?
Hasselmo, M. E. (2000) · Springer eBooks · doi:10.1007/978-1-4612-1302-4_5 · Cited by 13
Action potentials produce a long-term enhancement of M-current in frog sympathetic ganglion
Kirkwood, A., & Lisman, J. E. (1992) · Brain Research · doi:10.1016/0006-8993(92)90955-9 · Cited by 13
Predicting spike timings of current-injected neurons
Tsubo, Y., Kaneko, T., & Shinomoto, S. (2003) · Neural Networks · doi:10.1016/j.neunet.2003.11.005 · Cited by 12
Effects of a biologically active LHRH fragment on CA1 hippocampal neurons
Chen, Y., Wong, M. L., & Moss, R. L. (1993) · Peptides · doi:10.1016/0196-9781(93)90090-4 · Cited by 13
Effects of dithiothreitol, a sulfhydryl reducing agent, on CA1 pyramidal cells of the guinea pig hippocampus in vitro
Tolliver, J. M., & Pellmar, T. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90345-9 · Cited by 13
Altered inhibition in the hippocampal neural networks after spreading depression
Mesgari, M., Ghaffarian, N., Ghadiri, M. K., Sadeghian, H., Speckmann, E. ‐., Stummer, W., & Gorji, A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.07.035 · Cited by 12
SGK1.1 reduces Kainic acid-induced seizure severity and leads to rapid termination of seizures
Armas-Capote, N., Maglio, L. E., Pérez-Atencio, L., Martin-Batista, E., Reboreda, A., Barios, J. A., Hernandez, G., Alvarez de la Rosa, D., Lamas, J. A., Barrio, L. C., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhz302 · Cited by 12
Effect of low frequency repetitive transcranial magnetic stimulation on kindling-induced changes in electrophysiological properties of rat CA1 pyramidal neurons
Chameh, H. M., Janahmadi, M., Semnanian, S., Shojaei, A., & Mirnajafi‐Zadeh, J. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.023 · Cited by 12
Some Actions of 9‐Amino‐1,2,3,4‐Tetrahydroacridine (THA) on Cholinergic Transmission and Membrane Currents in Rat Sympathetic Ganglia
Marsh, S. J., Hubbard, A., & Brown, D. A. (1990) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1990.tb00024.x · Cited by 12
Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons
Upchurch, C., Combe, C., Knowlton, C., Rousseau, V., Gasparini, S., & Canavier, C. C. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1914-21.2022 · Cited by 12
Series solution to the first-passage-time problem of a Brownian motion with an exponential time-dependent drift
Urdapilleta, E. (2012) · Journal of Physics A Mathematical and Theoretical · doi:10.1088/1751-8113/45/18/185001 · Cited by 11
Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family
Kim, K.-W., Kim, K., Kim, H., Kim, B.-I., Bæk, M., & Suh, B. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110200118 · Cited by 11
Spike initiating dynamics of the neuron with different adaptation mechanisms to extracellular electric fields
Yi, G., Wang, J., Deng, B., & Wei, X. (2014) · Communications in Nonlinear Science and Numerical Simulation · doi:10.1016/j.cnsns.2014.07.020 · Cited by 11
Integration of Subthreshold and Suprathreshold Excitatory Barrages along the Somatodendritic Axis of Pyramidal Neurons
Oviedo, H. V., & Reyes, A. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033831 · Cited by 11
The action of anaesthetics and high pressure on neuronal discharge patterns
Wann, K. T., & Southan, A. P. (1992) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(92)90277-q · Cited by 11
Plasticity of intrinsic firing response gain in principal hippocampal neurons following pilocarpine-induced status epilepticus
Tamir, I., Daninos, M., & Yaari, Y. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.013 · Cited by 11
The Unexplored Territory of Neural Models: Potential Guides for Exploring the Function of Metabotropic Neuromodulation
Hasselmo, M. E., Alexander, A. S., Hoyland, A., Robinson, J. C., Bezaire, M. J., Chapman, G. W., Saudargienė, A., Carstensen, L. C., & Dannenberg, H. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.048 · Cited by 11
Experimental and theoretical demonstration of noise shaping by interspike interval correlations (Invited Paper)
Chacron, M. J., Lindner, B., Maler, L., Longtin, A., & Bastian, J. (2005) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.610938 · Cited by 11
Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina
Nemargut, J. P., Zhu, J.-L., Savoie, B. T., & Wang, G.-Y. (2008) · Vision Research · doi:10.1016/j.visres.2008.11.008 · Cited by 11
Simulating posterior parietal damage in a biologically plausible framework: Neuropsychological tests of the search over time and space model
Mavritsaki, E., Heinke, D. G., Deco, G., & Humphreys, G. W. (2009) · Cognitive Neuropsychology · doi:10.1080/02643290903424329 · Cited by 11
Incorporating spike-rate adaptation into a rate code in mathematical and biological neurons
Ralston, B., Flagg, L. Q., Faggin, E., & Birmingham, J. T. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00993.2015 · Cited by 11
Structural and Functional Properties of Hippocampal Neurons
Spruston, N., Piskorowski, R. A., Chevaleyre, V., Eyre, M. D., McBain, C. J., & Bartos, M. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0005 · Cited by 11
Development of Ca2+‐channel and BK‐channel expression in embryos and larvae of Xenopus laevis
Jiménez-González, C., McLaren, G. J., & Dale, N. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02955.x · Cited by 11
Model experiments on squid axons and NG108-15 mouse neuroblastoma × rat glioma hybrid cells
Schmitt, H., & Meves, H. (1995) · Journal of Physiology-Paris · doi:10.1016/0928-4257(96)83635-7 · Cited by 11
Cellular Mechanisms of Interictal-Ictal Transitions
Prince, D. A. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5556-4_4 · Cited by 11
Spontaneous alternation of place-cell sequences in the open field through spike frequency adaptation
Widloski, J., Theurel, D., & Foster, D. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115475 · Cited by 13
Modeling multiple time scale firing rate adaptation in a neural network of local field potentials
Lundstrom, B. N. (2014) · Journal of Computational Neuroscience · doi:10.1007/s10827-014-0536-2 · Cited by 10
Muscarinic regulation of the neuronal Na+/K+‐ATPase in rat hippocampus
Mohan, S., Tiwari, M. N., Stanojević, M., Biala, Y., & Yaari, Y. (2021) · The Journal of Physiology · doi:10.1113/jp281460 · Cited by 10
Gain Modulation of Cholinergic Neurons in the Medial Septum‐Diagonal Band of Broca Through Hyperpolarization
Melonakos, E. D., White, J. A., & Fernandez, F. R. (2016) · Hippocampus · doi:10.1002/hipo.22653 · Cited by 9
A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition
Melonakos, E. D., White, J. A., & Fernandez, F. R. (2018) · Hippocampus · doi:10.1002/hipo.23051 · Cited by 11
Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts
Gao, X., Bender, F., Soh, H., Chen, C., Altafi, M., Schütze, S., Heidenreich, M., Gorbati, M., Corbu, M.-A., Carús-Cadavieco, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24805-2 · Cited by 11
Unilateral cholinergic stimulation of the rabbit's cerebellar flocculus: asymmetric effects on optokinetic responses
Tan, H. S., Collewijn, H., & van der Steen, J. (1993) · Experimental Brain Research · doi:10.1007/bf00229025 · Cited by 10
l-Deprenyl (selegiline) limits the repetitive firing of action potentials in rat hippocampal CA1 neurons via a dopaminergic mechanism
Huang, C., Tsai, J.-J., & Hsu, K. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01482-5 · Cited by 10
Effects of Kainate on CA1 Hippocampal Neurons Recorded in Vitro
Cherubini, E., Rovira, C., Gho, M., & Ben‐Ari, Y. (1986) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-7971-3_36 · Cited by 10
Characterization of deep dorsal horn neurones in the rat spinal cord in vitro: Synaptic and excitatory amino acid induced excitations
King, A. E., & Thompson, S. (1989) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(89)90204-1 · Cited by 10
Ionic basis for the electroresponsiveness of guinea‐pig ventromedial hypothalamic neurones in vitro.
Minami, T., Oomura, Y., & Sugimori, M. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016277 · Cited by 10
Traveling Waves in One-Dimensional Excitable Media
Bressloff, P. C. (2013) · Lecture notes on mathematical modelling in the life sciences · doi:10.1007/978-1-4614-8866-8_2 · Cited by 8
Pharmacological modulation of the M-current shapes locomotor function in developing zebrafish
Gaudreau, S. F., & Bui, T. V. (2025) · Journal of Neurophysiology · doi:10.1152/jn.00003.2025 · Cited by 9
Membrane Potential and Action Potential
McCormick, D. A. (2004) · Elsevier eBooks · doi:10.1016/b978-012148660-0/50006-8 · Cited by 9
Local Optogenetic Induction of Fast (20–40 Hz) Pyramidal-Interneuron Network Oscillations in the In Vitro and In Vivo CA1 Hippocampus: Modulation by CRF and Enforcement of Perirhinal Theta Activity
Dine, J., Genewsky, A. J., Hladky, F., Wotjak, C. T., Deussing, J. M., Zieglgänsberger, W., Chen, A., & Eder, M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00108 · Cited by 9
Chronic α1-Na/K-ATPase inhibition reverses the elongation of the axon initial segment of the hippocampal CA1 pyramidal neurons in Angelman syndrome model mice
Rayi, P. R., Bagrov, A. Y., & Kaphzan, H. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00907-1 · Cited by 11
CAMKII Activation Is Not Required for Maintenance of Learning-Induced Enhancement of Neuronal Excitability
Liraz, O., Rosenblum, K., & Barkai, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004289 · Cited by 9
Role of protein kinase C in modulation of excitability of CA1 pyramidal neurons in the rat
Grabauskas, G., Chapman, H., & Wheal, H. V. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.014 · Cited by 9
Cellular mechanisms for altered learning in aging
Oh, M. M., & Disterhoft, J. F. (2009) · Future Neurology · doi:10.2217/fnl.09.74 · Cited by 9
Selective attenuation of Ether-a-go-go related K+ currents by endogenous acetylcholine reduces spike-frequency adaptation and network correlation
Cui, E., & Strowbridge, B. W. (2019) · eLife · doi:10.7554/elife.44954 · Cited by 10
An Introduction to In Vitro Slice Approaches for the Study of Neuronal Circuitry
Varela, C., Llano, D. A., & Theyel, B. B. (2011) · Neuromethods · doi:10.1007/7657_2011_19 · Cited by 8
Adenosine potentiates the delayed-rectifier potassium conductance but has no effect on the hyperpolarization-activated Ih current in frog melanotrophs
Mei, Y., Soriani, O., Castel, H., Vaudry, H., & Cazin, L. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00184-x · Cited by 9
Low concentrations of gaba reduce accommodation in primary afferent neurons by an action at GABAB receptors
Schlichter, R., Desarménien, M. G., Volsi, G. L., Desaulles, E., & FELTZ, P. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90099-6 · Cited by 9
Depression of spike adaptation and afterhyperpolarization by 4-aminopyridine in hippocampal neurons
Matsuda, Y., Yoshida, S., Fujimura, K., & Nakamura, M. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90281-8 · Cited by 9
Functional roles for the slow afterhyperpolarization: inferences from incorporation of features of the slow gK+(Ca) into densely connected artificial neural networks
Berner, J. E. (1991) · Network Computation in Neural Systems · doi:10.1088/0954-898x_2_1_001 · Cited by 8
The antidepressant imipramine inhibits the M-type K+ current in rat sympathetic neurons
Cuellar-Quintero, J. L., Garcı́a, D. E., & Cruzblanca, H. (2001) · Neuroreport · doi:10.1097/00001756-200107200-00030 · Cited by 9
The role of adaptation in generating monotonic rate codes in auditory cortex
Lee, J. H., Wang, X., & Bendor, D. (2020) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007627 · Cited by 7
Simulations reveal how M-currents and memory-based inputs from CA3 enable single neuron mismatch detection for EC3 inputs to the CA1 subfield of hippocampus
Berteau, S., & Bullock, D. H. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00238.2019 · Cited by 6
Short and long-term adaptation in the auditory nerve stimulated with high-rate electrical pulse trains are better described by a power law
van Gendt, M. J., Siebrecht, M., Briaire, J. J., Bohté, S. M., & Frijns, J. H. M. (2020) · Hearing Research · doi:10.1016/j.heares.2020.108090 · Cited by 8
Sex differences in electrophysiological properties and voltage-gated ion channel expression in the paraventricular thalamic nucleus following repeated stress
Corbett, B. F., Urban, K. R., Luz, S., Yan, J. H., Arner, J., & Bhatnagar, S. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00460-0 · Cited by 8
Background potassium concentrations and epileptiform discharges
Gorji, A., Möddel, G., & Speckmann, E. ‐. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03742-3 · Cited by 8
Pharmacology of currents underlying the different firing patterns of spinal sensory neurons and interneurons identified in vivo using multivariate analysis
Winlove, C. I. P., & Roberts, A. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00779.2010 · Cited by 8
Cellular Mechanisms for Nimodipine’s Reduction of Aging-Related Learning Deficits
Thompson, L. T., Moyer, J. R., Black, J., & Disterhoft, J. F. (1992) · Advances in behavioral biology · doi:10.1007/978-1-4615-3432-7_19 · Cited by 8
Epileptic focus induced in rat by intrahippocampal cholera toxin: Neuronal properties in vitro
Watts, A. E., Whittington, M. A., & Jefferys, J. G. R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90453-m · Cited by 8
Voltage-Gated and Ca2+-Activated Conductances Mediating and Controlling Graded Electrical Activity in Crayfish Muscle
Araque, A., Marchand, A. R., & Buño, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.5.2338 · Cited by 8
Concentrations of carbachol stimulating phosphoinositide hydrolysis cause a sustained decrease in membrane potential and firing rate: role of inositol and inositol polyphosphate second messengers
Pontzer, N. J., Madamba, S. G., Siggins, G. R., & Crews, F. T. (1992) · Brain Research · doi:10.1016/0006-8993(92)91474-s · Cited by 8
Short-term neuronal and synaptic plasticity act in synergy for deviance detection in spiking networks
Kern, F. B., & Chao, Z. C. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011554 · Cited by 10
Abbreviated Action Potential Kinetics in a Mouse Model of Potassium Channel Overexpression During Hippocampal Development
Williams, S. H., & Sutherland, M. L. (2004) · Cellular and Molecular Neurobiology · doi:10.1023/b:cemn.0000022772.82534.39 · Cited by 7
Identification of adult spinal Shox2 neuronal subpopulations based on unbiased computational clustering of electrophysiological properties
Garcia-Ramirez, D. L., Singh, S., McGrath, J. R., Ha, N. T., & Dougherty, K. J. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.957084 · Cited by 8
rdHSV-CA8 non-opioid analgesic gene therapy decreases somatosensory neuronal excitability by activating Kv7 voltage-gated potassium channels
Kandel, M. B., Zhuang, G. Z., Goins, W. F., Marzulli, M., Zhang, M., Glorioso, J. C., Kang, Y., Levitt, A. E., Kwok, W., Levitt, R. C., et al. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1398839 · Cited by 9
Fast BK-Type Channel Mediates the Ca2+-Activated K+Current in Crayfish Muscle
Araque, A., & Buño, W. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1655 · Cited by 7
The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area
Kernig, K., Kirschstein, T., Würdemann, T. J., Rohde, M., & Köhling, R. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.008 · Cited by 7
Nicotinic receptor–mediated biphasic effect on neuronal excitability in chick lateral spiriform neurons
Liu, Y., Guo, J., & Chiappinelli, V. A. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.07.009 · Cited by 7
The β-carboline derivative DMCM decreases γ-aminobutyric acid responses and Ca2+-mediated K+-conductance in rat neocortical neurons in vitro
Capogna, M., Berretta, N., Berton, F., Bianchi, R., Brunelli, M., & Francesconi, W. G. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90185-6 · Cited by 7
Fusimotor effects of midbrain stimulation on jaw muscle spindles of the anaesthetized cat
Taylor, A., Donga, R., & J�ch, P. J. W. (1993) · Experimental Brain Research · doi:10.1007/bf00227778 · Cited by 7
Alaproclate Increases the Excitability of Hippocampal CA1 Pyramidal Cells and Blocks the Slow After‐hyperpolarization
Hedlund, B., & Andersen, P. N. (1989) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1989.tb01153.x · Cited by 7
Norepinephrine activates potassium conductance in neurons of the turtle cerebral cortex
Blanton, K. J., & Kriegstein, A. R. (1992) · Brain Research · doi:10.1016/0006-8993(92)90561-m · Cited by 7
Inferring and validating mechanistic models of neural microcircuits based on spike-train dataPreprint
Ladenbauer, J., McKenzie, S., English, D. F., Hagens, O., & Ostojic, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/261016 · Cited by 9
Distinct neuron phenotypes may serve object feature sensing in the electrosensory lobe of Gymnotus omarorum
Nogueira, J., Castelló, M. E., Lescano, C., & Caputi, A. A. (2021) · Journal of Experimental Biology · doi:10.1242/jeb.242242 · Cited by 5
Spontaneous Motion on Two-Dimensional Continuous Attractors
Fung, C. C. A., & Амари, Ш.-И. (2015) · Neural Computation · doi:10.1162/neco_a_00711 · Cited by 6

Authors: Madison, D. V., & Nicoll, R. A.
ORCID: Madison, D V
Venue: The Journal of Physiology
Publisher: Wiley
Published: 1984-09
Volume: 354
Issue: 1
Pages: 319-331
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.1984.sp015378
PMC: PMC1193414
OpenAlex: W2048528277
Cited by: 746
References: 35
Citations by year: 2026: 7 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 19 · 2018: 12 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 21 · 2013: 30 · 2012: 30
FWCI: 6.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: CA1 pyramidal neurons, hippocampus, accommodation, afterhyperpolarization, calcium-activated potassium current, M-current, carbachol, cadmium, EGTA, interspike intervals, neuronal excitability
MeSH terms: Action Potentials, Animals, Cadmium, Calcium, Calcium Channel Blockers, Egtazic Acid, Electric Conductivity, Hippocampus, Membrane Potentials, Neurons, Potassium, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks