Cited by 746Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

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Madison, D V, Nicoll, R A·1984·The Journal of Physiology

DOI 10.1113/jphysiol.1984.sp015378PMC PMC1193414

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Abstract

Experiments using intracellular recording techniques were performed on rat hippocampal neurones in vitro, to study the discharge properties of these cells. When CA 1 pyramidal cells were excited by injecting long depolarizing current pulses (approximately 600‐800 ms), they responded with an initial rapid action potential discharge which slowed, or accommodated, and then stopped after 200‐300 ms. The train of action potentials was followed by a hyperpolarization which was due primarily to calcium‐activated potassium conductance (GK(Ca]. The amplitude of this hyperpolarization increased with an increasing number of action potentials in the initial discharge. Blocking the calcium‐activated potassium conductance, by injecting EGTA into the cell, by bathing the cell in cadmium, a calcium channel blocker, or by bathing the cell in calcium‐free medium, reduced the after‐hyperpolarization (a.h.p.) and accommodation such that the frequency of action potential discharge increased and the duration of this discharge was prolonged. Blocking the calcium‐activated potassium conductance had a greater effect on discharge frequency later in the action potential train, as late interspike intervals were shortened more than early ones by the application of cadmium or of calcium‐free medium. This was presumably because the calcium‐activated potassium conductance was more developed later in the train. Accommodation was not completely abolished in the absence of calcium and presence of cadmium, suggesting that other factors, in addition to calcium‐activated potassium conductance, contributed to this process. This remaining accommodation was reduced by low doses of carbachol, suggesting that the M‐current also plays a role in accommodation. We conclude that accommodation of the action potential discharge of hippocampal pyramidal cells may be regulated by at least two potassium currents: the calcium‐activated potassium current and the M‐current. Both of these currents are turned on during excitation of the neurone and act in an inhibitory manner on that neurone to limit further action potential discharge.

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Authors: Madison, D. V., & Nicoll, R. A.
ORCID: Madison, D V
Venue: The Journal of Physiology
Publisher: Wiley
Published: 1984-09
Volume: 354
Issue: 1
Pages: 319-331
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.1984.sp015378
PMC: PMC1193414
OpenAlex: W2048528277
Cited by: 746
References: 35
Citations by year: 2026: 7 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 19 · 2018: 12 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 21 · 2013: 30 · 2012: 30
FWCI: 6.39
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: CA1 pyramidal neurons, hippocampus, accommodation, afterhyperpolarization, calcium-activated potassium current, M-current, carbachol, cadmium, EGTA, interspike intervals, neuronal excitability
MeSH terms: Action Potentials, Animals, Cadmium, Calcium, Calcium Channel Blockers, Egtazic Acid, Electric Conductivity, Hippocampus, Membrane Potentials, Neurons, Potassium, Rats, In Vitro Techniques

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Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.

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