The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro.
Open accessAbstract
Experiments using intracellular recording techniques were performed on rat hippocampal neurones in vitro, to study the discharge properties of these cells. When CA 1 pyramidal cells were excited by injecting long depolarizing current pulses (approximately 600‐800 ms), they responded with an initial rapid action potential discharge which slowed, or accommodated, and then stopped after 200‐300 ms. The train of action potentials was followed by a hyperpolarization which was due primarily to calcium‐activated potassium conductance (GK(Ca]. The amplitude of this hyperpolarization increased with an increasing number of action potentials in the initial discharge. Blocking the calcium‐activated potassium conductance, by injecting EGTA into the cell, by bathing the cell in cadmium, a calcium channel blocker, or by bathing the cell in calcium‐free medium, reduced the after‐hyperpolarization (a.h.p.) and accommodation such that the frequency of action potential discharge increased and the duration of this discharge was prolonged. Blocking the calcium‐activated potassium conductance had a greater effect on discharge frequency later in the action potential train, as late interspike intervals were shortened more than early ones by the application of cadmium or of calcium‐free medium. This was presumably because the calcium‐activated potassium conductance was more developed later in the train. Accommodation was not completely abolished in the absence of calcium and presence of cadmium, suggesting that other factors, in addition to calcium‐activated potassium conductance, contributed to this process. This remaining accommodation was reduced by low doses of carbachol, suggesting that the M‐current also plays a role in accommodation. We conclude that accommodation of the action potential discharge of hippocampal pyramidal cells may be regulated by at least two potassium currents: the calcium‐activated potassium current and the M‐current. Both of these currents are turned on during excitation of the neurone and act in an inhibitory manner on that neurone to limit further action potential discharge.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Halliwell, J. V., & Adams, P. R. (1982) · Brain Research · doi:10.1016/0006-8993(82)90954-4 · Cited by 1,046
CALCIUM-DEPENDENT POTASSIUM ACTIVATION IN NERVOUS TISSUES
Meech, R. W. (1978) · Annual Review of Biophysics and Bioengineering · doi:10.1146/annurev.bb.07.060178.000245 · Cited by 754
Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma
Connor, J. A., & Stevens, C. F. (1971) · The Journal of Physiology · doi:10.1113/jphysiol.1971.sp009366 · Cited by 735
Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus
Madison, D. V., & Nicoll, R. A. (1982) · Nature · doi:10.1038/299636a0 · Cited by 581
Self-citationA calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro
Alger, B. E., & Nicoll, R. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014255 · Cited by 528
Self-citationPharmacological inhibition of the M‐current
Adams, P. R., Brown, D. A., & Constanti, A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014411 · Cited by 431
Alger, B. E., & Nicoll, R. A. (1980) · Science · doi:10.1126/science.7444438 · Cited by 421
Self-citationHaas, H. L., & Konnerth, A. (1983) · Nature · doi:10.1038/302432a0 · Cited by 414
Acetylcholine Mediates a Slow Synaptic Potential in Hippocampal Pyramidal Cells
Cole, A. E., & Nicoll, R. A. (1983) · Science · doi:10.1126/science.6612345 · Cited by 374
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–744 of 744
Hönigsperger, C. (2016) · NORA - Norwegian Open Research Archives
Raabe, W. A. (1986) · Springer eBooks · doi:10.1007/978-3-642-70744-5_38
The contribution of the sodium channel subunit Na V 1.6 to neuronal excitability
Mathematisch-naturwissenschaftlichen Fakultät, I. (2009)
Chiang, E. C. (2008) · OhioLink ETD Center (Ohio Library and Information Network)
Minimum-error, energy-constrained source coding by sensory neurons
Johnson, E. C. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
MECHANISMS OF SEIZURE REDUCTION BY LOW FREQUENCY ELECTRICAL STIMULATION
Toprani, S. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
Calcium Regulation of a Slow AHP in Hippocampal Pyramidal Cells
Miclat, J. (2018) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/31781
Hegemann, R. U. (2018) · Otago University Research Archive (University of Otago)
Neural Networks and Neurocomputational Modeling
Toutounji, H., Hertäg, L., & Durstewitz, D. (2018) · Wiley eBooks · doi:10.1002/9781119170174.epcn517
Phasic dopamine release: its origin and function in reward seeking
Beyene, M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/jt5q-0n02
Cakan, C., & Obermayer, K. (2019) · arXiv (Cornell University)
SK3-overexpression drives sex-dimorphic working and social memory impairment in micePreprint
Campos, A. C., Scarante, F. F., Martin, S., Lazzarini, M., Krauter, D., Souza‐Silva, M. A. D., Pardo, L. A., Stühmer, W., & Bel, E. A. D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.31.230656
Divergence in Neuronal Calcium Dysregulation in Brain Aging and Animal Models of AD
Ghoweri, A. O. (2020) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2020.521
Chameh, H. M., Semnanian, S., Ahmadi, M. J., Shojaee, A., Asgari, A., & Mirnajafi-Zadeh, S. J. (2015)
Ghotbeddin, Z., Mirnajafi‐Zadeh, J., Semnanian, S., & Janahmadi, M. (2012)
Economo, M. N., Martínez, J. J., & White, J. A. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5227-0_6
Mitochondrial dysfunction and its consequences in the context of neurodegeneration
Key, J. (2021) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.62414
Economo, M. N., Noueihed, J., Martínez, J. J., & White, J. A. (2020) · Springer eBooks · doi:10.1007/978-3-030-43395-6_16
Gating Domain of Calcium‐Activated Potassium Channel with Calcium and Calmodulin
Schumacher, M. A. (2004) · Handbook of Metalloproteins · doi:10.1002/0470028637.met041
Muellerleile, J. (2022) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt) · doi:10.21248/gups.68693
Wang, J., Deng, B., Wang, J., Lei, X., & Liu, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3331364/v1
A Nonlinear Map Describing Relaxation to Cluster States in an Adapting Neuronal Network
Tse, K. N., Ermentrout, B., & Rubin, J. E. (2025) · SIAM Journal on Applied Dynamical Systems · doi:10.1137/24m1695622
Wave Propagation Along Spiny Dendrites
Bressloff, P. C. (2013) · Lecture notes on mathematical modelling in the life sciences · doi:10.1007/978-1-4614-8866-8_3
Biophysical mechanisms underlying the generation and maintenance of rule-learning engram
Kundu, S., Keren, D., Reuveni, I., Zidan, S., Kumar, A., Schiller, J., & Barkai, E. (2026) · Communications Biology · doi:10.1038/s42003-026-10243-7
Nimodipine and Learning in Aging Rabbits
Disterhoft, J. F., Moyer, J. R., Thompson, L. T., & Kowalska, M. (1993) · Springer eBooks · doi:10.1007/978-3-642-95716-1_8
Bressloff, P. C. (2013) · Lecture notes on mathematical modelling in the life sciences · doi:10.1007/978-1-4614-8866-8_1 · Cited by 1
Shao, L., Xu, Z., Sun, Q., Li, F., & Yang, Q. (2026) · IEEE Transactions on Cognitive and Developmental Systems · doi:10.1109/tcds.2025.3650131
Artinian, J. (2012) · theses.fr (ABES) · doi:10.70675/3fc5e27cz46c8z47b1zb501z05b8e8289a32
Modèles cellulaires de champs neuronaux dynamiques
de Vangel, B. C. (2016) · theses.fr (ABES) · doi:10.70675/5349b5f4z8420z40fdz9e0azc9800ad98f7d
Neuronal properties and synaptic connectivity in rodent presubiculum
Simonnet, J. (2014) · theses.fr (ABES) · doi:10.70675/bdae6cc1z374ez4e36z8d20zce45fe5c356e
Leroux, M. (2023) · theses.fr (ABES) · doi:10.70675/d51b586bz96daz4ecbzbac2zc54c3576aef2
Maturation of spinal motor control through developmental changes in ion currents
Gaudreau, S. F., & Bui, T. V. (2026) · The Journal of Physiology · doi:10.1113/jp290720
Colangelo, C., Múñoz, A., Antonietti, A., Sood, V., Antón‐Fernández, A., Herttuainen, J., Romani, A., DeFelipe, J., & Ramaswamy, S. (2026) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1014460
Spectral methods for neural field models with synaptic depression and spike frequency adaptation
Wang, J., Chen, Y., & Qin, F. (2026) · Mathematics and Computers in Simulation · doi:10.1016/j.matcom.2026.07.009
Powell, G. L. (2014) · UA Campus Repository (The University of Arizona)
Shinpo (2000) · doi:10.1002/1097-4547(20001101)62:3
Metadata
- Authors
- Madison, D. V., & Nicoll, R. A.
- ORCID
- Madison, D V
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1984-09
- Volume
- 354
- Issue
- 1
- Pages
- 319-331
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1193414
- OpenAlex
- W2048528277
- Cited by
- 746
- References
- 35
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 6 · 2023: 11 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 19 · 2018: 12 · 2017: 18 · 2016: 21 · 2015: 15 · 2014: 21 · 2013: 30 · 2012: 30
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- CA1 pyramidal neurons, hippocampus, accommodation, afterhyperpolarization, calcium-activated potassium current, M-current, carbachol, cadmium, EGTA, interspike intervals, neuronal excitability
- MeSH terms
- Action Potentials, Animals, Cadmium, Calcium, Calcium Channel Blockers, Egtazic Acid, Electric Conductivity, Hippocampus, Membrane Potentials, Neurons, Potassium, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
