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Cited by 341Ion channel regulation and functionPain Mechanisms and TreatmentsIon Channels and Receptors

Electrical properties of rat dorsal root ganglion neurones with different peripheral nerve conduction velocities

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Harper, A A, Lawson, S N·1985·The Journal of Physiology
DOI 10.1113/jphysiol.1985.sp015574PMC PMC1193364
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Abstract

The electrical characteristics of individual rat dorsal root ganglion neurones were studied and related to the peripheral axon conduction velocity and morphological cell type. Neurones were divided into four groups based on the conduction velocity of their peripheral axons (A alpha, 30-55 m/s; A beta, 14-30 m/s; A delta, 2.2-8 m/s and C less than 1.4 m/s). Electrophysiological parameters examined included membrane potential, action potential amplitude and duration, after-potential height and duration, input resistance and the occurrence of time-dependent rectification. The mean duration of the somatic action potentials was found to be characteristic for each of the conduction velocity groupings. However, there was considerable overlap between groups. The fast-conducting (A alpha) and slowly conducting (A delta) myelinated fibres had short-duration action potentials, within the ranges 0.49-1.35 and 0.5-1.7 ms at the base respectively. The A beta and C cells had somatic action potentials with durations in the ranges of 0.6-2.9 and 0.6-7.4 ms respectively. The longer action potential durations could be related to the presence of an inflexion on the repolarizing phase seen in a third of A beta neurones (called A beta I neurones) and in all C neurones. The action potential overshoot was larger in C neurones and A beta I neurones than in the other neurone groups. The mean duration of the after-hyperpolarization was several times greater in C neurones than in A neurones. A delta neurones displayed the shortest and greatest amplitude after-hyperpolarizations. Large, long-lasting after-hyperpolarizations were not limited to neurones displaying an inflexion. The electrophysiological properties of the soma membrane of A delta neurones closely resembled those of A alpha neurones, while in several respects those of C neurones resembled the A beta I neuronal properties. The input resistance was found to be much greater in C than in A cells, although there was no significant difference between specific membrane resistance values calculated for the different groups. A number of A cells exhibited time-dependent rectification.

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Authors
Harper, A. A., & Lawson, S. N.
Venue
The Journal of Physiology
Publisher
Wiley
Published
1985-02
Volume
359
Issue
1
Pages
47-63
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.1985.sp015574
PMC
PMC1193364
OpenAlex
W2117531417
Cited by
341
References
23
Citations by year
2026: 1 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 14 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 10 · 2013: 11 · 2012: 10
FWCI
3.48
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
dorsal root ganglion neurons, peripheral nerve conduction velocity, afterhyperpolarization, input resistance, A-delta fibers, C-fibers
MeSH terms
Action Potentials, Animals, Microbial Collagenase, Electric Conductivity, Female, Ganglia, Spinal, Membrane Potentials, Neural Conduction, Neurons, Rats, Inbred Strains, Sciatic Nerve, Time Factors, Rats

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