The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans
Open accessAbstract
1. Muscle sympathetic nerve activity (MSA) was recorded in the peroneal nerve at the knee by microneurography in ten healthy subjects and determinations were made simultaneously of intra-arterial blood pressure, and whole-body and cardiac noradrenaline spillover to plasma. Measurements were made at rest, during isometric handgrip at 30% of maximum power and during stress induced by forced mental arithmetic. 2. At rest there were significant positive correlations between spontaneous MSA (expressed as number of sympathetic bursts min-1) and both spillover of noradrenaline from the heart and concentration of noradrenaline in coronary sinus venous plasma. 3. Both isometric handgrip and mental arithmetic led to sustained increases of blood pressure, heart rate and MSA. Plasma concentrations of noradrenaline and spillover of noradrenaline (total body and cardiac) increased. In general the effects were more pronounced during handgrip than during stress. 4. When comparing effects during handgrip and stress the ratio between the fractional increases of MSA and cardiac noradrenaline spillover were significantly greater during handgrip. 5. The data suggest (a) that there are proportional interindividual differences in the strength of resting sympathetic activity to heart and skeletal muscle which are determined by a common mechanism and (b) that handgrip and mental stress are associated with differences in balance between sympathetic outflows to heart and skeletal muscle.
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“Importantly, however, evidence does suggest that measures of cardiac norepinephrine spillover do correlate well with recordings of peripheral sympathetic nerve activity (41).”
From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [41]
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Cites
Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves
Vallbo, A. B., Hagbarth, K. E., Torebjork, H. E., & Wallin, B. G. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.919 · Cited by 1,507
General Characteristics of Sympathetic Activity in Human Muscle Nerves
Delius, W., Hagbarth, K. ‐., Hongell, A., & Wallin, B. G. (1972) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1972.tb05157.x · Cited by 831
Self-citationOverflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794
Mark, A. L., Victor, R. G., Nerhed, C., & Wallin, B. G. (1985) · Circulation Research · doi:10.1161/01.res.57.3.461 · Cited by 748
Esler, M., Jennings, G., Korner, P., Willett, I., Dudley, F., Hasking, G., Anderson, W., & Lambert, G. (1988) · Hypertension · doi:10.1161/01.hyp.11.1.3 · Cited by 642
Self-citationThe variability of muscle nerve sympathetic activity in resting recumbent man
Sundlöf, G., & Wallin, B. G. (1977) · The Journal of Physiology · doi:10.1113/jphysiol.1977.sp012050 · Cited by 442
Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans
Somers, V. K., Mark, A. L., Zavala, D. C., & Abboud, F. M. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.2095 · Cited by 365
Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans.
Victor, R. G., Bertocci, L. A., Pryor, S. L., & Nunnally, R. L. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113730 · Cited by 343
Victor, R. G., Pryor, S. L., Secher, N. H., & Mitchell, J. H. (1989) · Circulation Research · doi:10.1161/01.res.65.2.468 · Cited by 241
SYMPATHETIC ACTIVITY IN MAN AFTER SPINAL CORD INJURY
Stjernberg, L., Blumberg, H., & Wallin, B. G. (1986) · Brain · doi:10.1093/brain/109.4.695 · Cited by 233
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Metadata
- Authors
- Wallin, B. G., Esler, M., Dorward, P., Eisenhofer, G., Ferrier, C., Westerman, R., & Jennings, G.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- ORCID
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1992-07
- Volume
- 453
- Issue
- 1
- Pages
- 45-58
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC1175546
- OpenAlex
- W2138399442
- Cited by
- 298
- References
- 29
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 11 · 2017: 4 · 2016: 7 · 2015: 16 · 2014: 18 · 2013: 7 · 2012: 14
- FWCI
- 16.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- muscle sympathetic nerve activity, peroneal nerve, isometric handgrip, mental arithmetic stress, blood pressure, heart rate, interindividual variability, sympathetic nervous system
- MeSH terms
- Adult, Aged, Blood Pressure, Heart, Heart Rate, Humans, Isometric Contraction, Male, Middle Aged, Muscles, Myocardium, Norepinephrine, Stress, Psychological, Sympathetic Nervous System
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