Cited by 298Cardiovascular and exercise physiologyHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

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Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans

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Wallin, B G, Esler, M, Dorward, P, Eisenhofer, G, Ferrier, C, Westerman, R, Jennings, G·1992·The Journal of Physiology

DOI 10.1113/jphysiol.1992.sp019217PMC PMC1175546

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Abstract

1. Muscle sympathetic nerve activity (MSA) was recorded in the peroneal nerve at the knee by microneurography in ten healthy subjects and determinations were made simultaneously of intra-arterial blood pressure, and whole-body and cardiac noradrenaline spillover to plasma. Measurements were made at rest, during isometric handgrip at 30% of maximum power and during stress induced by forced mental arithmetic. 2. At rest there were significant positive correlations between spontaneous MSA (expressed as number of sympathetic bursts min-1) and both spillover of noradrenaline from the heart and concentration of noradrenaline in coronary sinus venous plasma. 3. Both isometric handgrip and mental arithmetic led to sustained increases of blood pressure, heart rate and MSA. Plasma concentrations of noradrenaline and spillover of noradrenaline (total body and cardiac) increased. In general the effects were more pronounced during handgrip than during stress. 4. When comparing effects during handgrip and stress the ratio between the fractional increases of MSA and cardiac noradrenaline spillover were significantly greater during handgrip. 5. The data suggest (a) that there are proportional interindividual differences in the strength of resting sympathetic activity to heart and skeletal muscle which are determined by a common mechanism and (b) that handgrip and mental stress are associated with differences in balance between sympathetic outflows to heart and skeletal muscle.

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Authors: Wallin, B. G., Esler, M., Dorward, P., Eisenhofer, G., Ferrier, C., Westerman, R., & Jennings, G.
Affiliations: Baker Heart and Diabetes Institute (AU)
ORCID: Esler, M
Jennings, G
Venue: The Journal of Physiology
Publisher: Wiley
Published: 1992-07
Volume: 453
Issue: 1
Pages: 45-58
ISSN: 0022-3751 (ISSN-L)
1469-7793
DOI: 10.1113/jphysiol.1992.sp019217
PMC: PMC1175546
OpenAlex: W2138399442
Cited by: 298
References: 29
Citations by year: 2026: 3 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 6 · 2018: 11 · 2017: 4 · 2016: 7 · 2015: 16 · 2014: 18 · 2013: 7 · 2012: 14
FWCI: 16.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: The Journal of Physiology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: muscle sympathetic nerve activity, peroneal nerve, isometric handgrip, mental arithmetic stress, blood pressure, heart rate, interindividual variability, sympathetic nervous system
MeSH terms: Adult, Aged, Blood Pressure, Heart, Heart Rate, Humans, Isometric Contraction, Male, Middle Aged, Muscles, Myocardium, Norepinephrine, Stress, Psychological, Sympathetic Nervous System

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Simultaneous measurements of cardiac noradrenaline spillover and sympathetic outflow to skeletal muscle in humans

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