Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans.
Open accessAbstract
The purpose of this study was to determine the contribution of muscle afferents and central command in regulating sympathetic nerve activity during static exercise in humans. In 20 healthy subjects, we recorded heart rate, arterial pressure, and efferent sympathetic nerve activity in the leg during arm exercise. Microelectrodes were inserted percutaneously into a fascicle of the peroneal nerve to measure sympathetic discharge to muscle. Measurements were obtained in nine subjects during sustained handgrip (30% maximal voluntary contraction) followed by relaxation or by arrested circulation of the forearm. Heart rate and arterial pressure increased during the first and second minutes of handgrip. Muscle sympathetic nerve activity increased from 261 +/- 46 to 504 +/- 97 units (mean +/- SE; units = burst frequency X amplitude; P less than 0.05) during the second minute of handgrip. During forearm ischemia following handgrip, heart rate returned promptly to control, whereas arterial pressure and muscle sympathetic nerve activity (631 +/- 115 units) remained elevated. In contrast, muscle sympathetic nerve activity returned toward control during relaxation without arrested circulation. These data indicate that muscle sympathetic nerve activity is increased by stimulation of chemically sensitive muscle afferents. To determine the influence of central command on muscle sympathetic nerve activity, we compared responses during an involuntary and a voluntary biceps contraction, each at 20% maximal voluntary contraction. Both maneuvers raised arterial pressure, but heart rate increased only during voluntary contraction. More importantly, muscle sympathetic nerve activity rose during involuntary contraction, but fell during voluntary effort.(ABSTRACT TRUNCATED AT 250 WORDS)
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Identification of sympathetic bursts by two independent observers had a mean intraobserver variability of 4.3% and a mean interobserver variability of 9.1%.
“Mark et al. 18 reported a mean intraobserver variability of 4.3% and a mean interobserver variability of 9.1%.”
From Inhibition of muscle sympathetic nerve activity in humans by arginine vasopressin (1987) · cites this paper as [18]
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- Authors
- Mark, A. L., Victor, R. G., Nerhed, C., & Wallin, B. G.
- Affiliations
- Uppsala University (SE)
- ORCID
- Mark, A L
- Venue
- Circulation Research
- Published
- 1985-09
- Volume
- 57
- Issue
- 3
- Pages
- 461-469
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2064620945
- Cited by
- 748
- References
- 1
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 14 · 2023: 13 · 2022: 13 · 2021: 12 · 2020: 20 · 2019: 10 · 2018: 25 · 2017: 19 · 2016: 24 · 2015: 34 · 2014: 16 · 2013: 24 · 2012: 21
- FWCI
- 20.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-24962, HL-01362)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- muscle sympathetic nerve activity, static exercise, central command, muscle afferents, handgrip exercise, forearm ischemia, voluntary muscle contraction, heart rate, arterial pressure, peroneal nerve, sympathetic nervous system
- MeSH terms
- Adult, Blood Pressure, Female, Heart Rate, Humans, Isometric Contraction, Male, Mechanoreceptors, Middle Aged, Muscle Contraction, Muscles, Neurons, Afferent, Sympathetic Nervous System
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