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Cited by 282

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Inhibition of the active lymph pump by flow in rat mesenteric lymphatics and thoracic duct

Open access
Gashev, Anatoliy A., Davis, Michael J., Zawieja, David C.·2002·The Journal of Physiology
DOI 10.1113/jphysiol.2001.016642
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Abstract

There are only a few reports of the influence of imposed flow on an active lymph pump under conditions of controlled intraluminal pressure. Thus, the mechanisms are not clearly defined. Rat mesenteric lymphatics and thoracic ducts were isolated, cannulated and pressurized. Input and output pressures were adjusted to impose various flows. Lymphatic systolic and diastolic diameters were measured and used to determine contraction frequency and pump flow indices. Imposed flow inhibited the active lymph pump in both mesenteric lymphatics and in the thoracic duct. The active pump of the thoracic duct appeared more sensitive to flow than did the active pump of the mesenteric lymphatics. Imposed flow reduced the frequency and amplitude of the contractions and accordingly the active pump flow. Flow‐induced inhibition of the active lymph pump followed two temporal patterns. The first pattern was a rapidly developing inhibition of contraction frequency. Upon imposition of flow, the contraction frequency immediately fell and then partially recovered over time during continued flow. This effect was dependent on the magnitude of imposed flow, but did not depend on the direction of flow. The effect also depended upon the rate of change in the direction of flow. The second pattern was a slowly developing reduction of the amplitude of the lymphatic contractions, which increased over time during continued flow. The inhibition of contraction amplitude was dependent on the direction of the imposed flow, but independent of the magnitude of flow. Nitric oxide was partly but not completely responsible for the influence of flow on the mesenteric lymph pump. Exposure to NO mimicked the effects of flow, and inhibition of the NO synthase by NG‐monomethyl‐l‐arginine attenuated but did not completely abolish the effects of flow.

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Metadata

Authors
Gashev, A. A., Davis, M. J., & Zawieja, D. C.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2002-05
Volume
540
Issue
3
Pages
1023-1037
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2001.016642
OpenAlex
W2117107881
Cited by
282
References
2
FWCI
3.56
Type
journal article
Language
en
Open access
green

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