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Cited by 84Lymphatic System and DiseasesLymphatic Disorders and TreatmentsParasitic Diseases Research and Treatment

In vivo determination of collecting lymphatic vessel permeability to albumin: a role for lymphatics in exchange

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Scallan, Joshua P., Huxley, Virginia H.·2010·The Journal of Physiology
DOI 10.1113/jphysiol.2009.179622PMC PMC2821562
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Abstract

While it is well established that the lymphatic vasculature is central to fluid and solute homeostasis, how it accomplishes this task is not well defined. To clarify the basic mechanisms underlying basal fluid and solute homeostasis, we assessed permeability to rat serum albumin (PRSAs) in mesenteric collecting lymphatic vessels and venules of juvenile male rats. Using the quantitative microfluorometric technique originally developed for blood capillaries, we tested the hypothesis that as a consequence of venules and collecting lymphatics sharing a common embryological origin, their PRSAs would not differ significantly. Supporting our hypothesis, the median collecting lymphatic PRSAs (3.5 ± 1.0 × 10−7 cm s−1, N= 22) did not differ significantly from the median venular PRSAs (4.0 ± 1.0 × 10−7 cm s−1, N= 8, P= 0.61). For collecting lymphatics the diffusive permeability (Pd= 2.5 × 10−7 cm s−1) was obtained from the relationship of apparent PRSAs and pressure. While the measured PRSAs, Pd and estimated hydraulic conductivity of collecting lymphatics and venules were similar, the contribution of convective coupling differs as a result of the higher hydrostatic pressure experienced by venules relative to collecting lymphatics in vivo. In summary, the data demonstrate the capacity for collecting lymphatics to act as exchange vessels, able to extravasate solute and filter fluid. As a consequence these data provide experimental support for the theory that prenodal lymphatic vessels concentrate intraluminal protein.

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  • The permeability of initial lymphatics has not been systematically measured but is estimated to be three- to tenfold higher than that of collecting LVs.

    “The permeability of initial lymphatics has not been systematically measured but is estimated to be three- to tenfold higher than that of collecting LVs (31, 35), reflecting the functional differences between button and zipper junctions.”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [31]

    The Introduction distinguishes initial lymphatics from microlymphatics and says the study measures collecting lymphatics. The Discussion reports a measurement from one microlymphatic vessel of 12 × 10−7 cm s−1, versus a median of 3.5 × 10−7 cm s−1 for collecting lymphatics—roughly threefold higher. It does not establish a three- to tenfold estimate for initial lymphatics or explicitly state that their permeability has not been systematically measured. (LLM, conf=0.78)

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  • Collecting vessel permeability to albumin is comparable to that of venules.

    “Collecting vessel permeability to albumin has been measured only in a few studies (31–33) and is comparable to that of venules.”

    From Transport and Immune Functions of the Lymphatic System. (2025) · cites this paper as [31]

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1 of the 41 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

  1. Bingaman S, Lewis MD, Huxley VH. Determination of net molecular charge on serum albumin from 8 animal species. FASEB J. 2003;17:A135. [Google Scholar]
  2. Curry FE. Mechanics and thermodynamics of transcapillary exchange. In: Renkin EM, Michel CC, editors. Handbook of Physiology, section 2 The Cardiovascular System, vol IV, Microcirculation. Bethesda, MD: American Physiological Society; 1984. pp. 309–374. [Google Scholar]
  3. Gnepp DR. Lymphatics. In: Staub NC, Taylor AE, editors. Edema. New York: Raven Press; 1984. pp. 263–298. [Google Scholar]
  4. Landis EM, Pappenheimer JR. Exchange of substances through the capillary walls. In: Hamilton WF, editor. Handbook of Physiology, Section 2, Circulation. Vol. 2. Washington, DC: American Physiological Society; 1963. pp. 961–1034. [Google Scholar]
  5. Mayerson HS. The physiologic importance of lymph. In: Hamilton WF, editor. Handbook of Physiology, Section 2 Circulation. Vol. 2. Washington, DC: American Physiological Society; 1963. pp. 1035–1073. [Google Scholar]
  6. Ratnoff OD. The Microcirculation and Lymphatics. In: Berne RM, Levy MN, editors. Physiology. St Louis, MO: C.V. Mosby; 1983. pp. 517–530. [Google Scholar]
  7. Rumbaut RE. Nitric Oxide and Microvascular Permeability (Dissertation) Columbia, MO: Department of Medical Pharmacology and Physiology, University of Missouri at Columbia; 1998. [Google Scholar]
  8. Scallan JP, Huxley VH. Assessing rat mesenteric collecting lymphatic permeability to albumin (Abstract) Microcirculation. 2007;14:511. [Google Scholar]

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Authors
Scallan, J. P., & Huxley, V. H.
Affiliations
University of Missouri (US)
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2010-01
Volume
588
Issue
1
Pages
243-254
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2009.179622
PMC
PMC2821562
OpenAlex
W1489961950
Cited by
84
References
41
Citations by year
2026: 2 · 2024: 3 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 3 · 2019: 6 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 6 · 2012: 4
FWCI
2.33
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 3 d)
Locations
  • The Journal of Physiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Aeronautics and Space Administration
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL078816, R01HL078816, P01HL052490)
Topics
  • Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
  • Health Sciences › Medicine › Surgery › Lymphatic Disorders and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
Keywords
serum albumin, venules, hydraulic conductivity, convective coupling, hydrostatic pressure, protein concentration, mesenteric lymphatics
MeSH terms
Animals, Computer Simulation, Male, Models, Biological, Permeability, Serum Albumin, Rats, Sprague-Dawley, Lymphatic Vessels, Rats

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