The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function
Abstract
Endothelium‐dependent flow‐mediated dilatation (FMD) describes the vasodilatory response of a vessel to elevations in blood flow‐associated shear stress. Nitric oxide (NO), one of many vasoactive substances released by the endothelium in response to shear stress, is of particular interest to researchers as it is an antiatherogenic molecule, and a reduction in its bioavailability may play a role in the pathogenesis of vascular disease. The goal of many human studies is to create a shear stress stimulus that produces an NO‐dependent response in order to use the FMD measurements as an assay of NO bioavailability. The most common non‐invasive technique is the ‘reactive hyperaemia test’ which produces a large, transient shear stress profile and a corresponding FMD. Importantly, not all FMD is NO mediated and the stimulus creation technique is a critical determinant of NO dependence. The purpose of this review is to (1) explain that the mechanisms of FMD depend on the nature of the shear stress stimulus (stimulus response specificity), (2) provide an update to the current guidelines for FMD assessment, and (3) summarize the issues that surround the clinical utility of measuring both NO‐ and non‐NO‐mediated FMD. Future research should include (1) the identification and partitioning of mechanisms responsible for FMD in response to various shear stress profiles, (2) investigation of stimulus response specificity in coronary arteries, and (3) investigation of non‐NO FMD mechanisms and their connection to the development of vascular disease and occurrence of cardiovascular events.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
Celermajer, D. S., Sorensen, K. E., Gooch, V. M., Spiegelhalter, D. J., Miller, O. I., Sullivan, I. D., Lloyd, J. K., & Deanfield, J. E. (1992) · The Lancet · doi:10.1016/0140-6736(92)93147-f · Cited by 4,742
Corretti, M. C., Anderson, T. J., Benjamin, E. J., Celermajer, D., Charbonneau, F., Creager, M. A., Deanfield, J., Drexler, H., Gerhard-Herman, M., Herrington, D., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01746-6 · Cited by 4,604
Close Relation of Endothelial Function in the Human Coronary and Peripheral Circulations
Anderson, T. J., Uehata, A., Gerhard, M. D., Meredith, I. T., Knab, S., Delagrange, D., Lieberman, E. H., Ganz, P., Creager, M. A., Yeung, A. C., et al. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00327-4 · Cited by 2,033 · cited 4×
“Many studies have in fact noted an inverse relationship between vessel size and FMD (Celermajer et al. 1992; Anderson et al. 1995; Herrington et al. 2001) but the mechanism (that smaller vessels experience a larger stimulus) has not been reported.”
BackgroundInfluentialThe clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 3×
“exercise) have been demonstrated at the group level (Widlansky et al. 2003; Green et al. 2004); however, day to day variability in subject responses may limit the utility of using reactive hyperaemia testing to track an individual’s improvement in response to an intervention (Hijmering et al.”
BackgroundJoannides, R., Haefeli, W. E., Linder, L., Richard, V., Bakkali, E. H., Thuillez, C., & Lüscher, T. F. (1995) · Circulation · doi:10.1161/01.cir.91.5.1314 · Cited by 1,622
Hofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · Circulation · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603
Celermajer, D. S., Sorensen, K. E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J., & Deanfield, J. E. (1993) · Circulation · doi:10.1161/01.cir.88.5.2149 · Cited by 1,533
Prognostic Value of Coronary Vascular Endothelial Dysfunction
Halcox, J. P. J., Schenke, W. H., Zalos, G., Mincemoyer, R., Prasad, A., Waclawiw, M. A., Nour, K. R. A., & Quyyumi, A. A. (2002) · Circulation · doi:10.1161/01.cir.0000025404.78001.d8 · Cited by 1,385 · cited 2×
“Many studies have in fact noted an inverse relationship between vessel size and FMD (Celermajer et al. 1992; Anderson et al. 1995; Herrington et al. 2001) but the mechanism (that smaller vessels experience a larger stimulus) has not been reported.”
BackgroundFlow-induced release of endothelium-derived relaxing factor
Rubanyi, G. M., Romero, J. C., & Vanhoutte, P. M. (1986) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1986.250.6.h1145 · Cited by 1,366
Celermajer, D. S., Sorensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,335
Cited by
Tjønna, A. E., Lee, S. J., Rognmo, Ø., Stølen, T. O., Bye, A., Haram, P. M., Loennechen, J. P., Al-Share, Q. Y., Skogvoll, E., Slørdahl, S. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772822 · Cited by 1,145
Ramos, J. S., Dalleck, L. C., Tjonna, A. E., Beetham, K. S., & Coombes, J. S. (2015) · Sports Medicine · doi:10.1007/s40279-015-0321-z · Cited by 715
Ultrasound Assessment of Flow-Mediated Dilation
Harris, R. A., Nishiyama, S. K., Wray, D. W., & Richardson, R. S. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.150821 · Cited by 667
Mezzani, A., Hamm, L. F., Jones, A. M., McBride, P. E., Moholdt, T., Stone, J. A., Urhausen, A., & Williams, M. A. (2013) · European Journal of Preventive Cardiology · doi:10.1177/2047487312460484 · Cited by 550
Rimm, E. B., Appel, L. J., Chiuve, S. E., Djoussé, L., Engler, M. B., Kris-Etherton, P. M., Mozaffarian, D., Siscovick, D. S., Lichtenstein, A. H., & On behalf of the American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology (2018) · Circulation · doi:10.1161/cir.0000000000000574 · Cited by 500
Metadata
- Authors
- Pyke, K. E., & Tschakovsky, M. E.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2005-10
- Volume
- 568
- Issue
- 2
- Pages
- 357-369
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2120662805
- Cited by
- 614
- References
- 76
- FWCI
- 21.85
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function. https://app.cochat.ai/papers/10.1113/jphysiol.2005.089755
- The paper
- Pyke, K. E., & Tschakovsky, M. E. (2005). The relationship between shear stress and flow‐mediated dilatation: implications for the assessment of endothelial function. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2005.089755
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
