The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men: Resistance exercise volume and myofibrillar protein synthesis
Open accessAbstract
We aimed to determine if any mechanistic differences exist between a single set (1SET) and multiple sets (i.e. 3 sets; 3SET) of resistance exercise by utilizing a primed constant infusion of [ring-13C6]phenylalanine to determine myofibrillar protein synthesis (MPS) and Western blot analysis to examine anabolic signalling molecule phosphorylation following an acute bout of resistance exercise. Eight resistance-trained men (24+/-5 years, BMI=25+/-4 kg m2) were randomly assigned to perform unilateral leg extension exercise at 70% concentric one repetition maximum (1RM) until volitional fatigue for 1SET or 3SET. Biopsies from the vastus lateralis were taken in the fasted state (Fast) and fed state (Fed; 20 g of whey protein isolate) at rest, 5 h Fed, 24 h Fast and 29 h Fed post-exercise. Fed-state MPS was transiently elevated above rest at 5 h for 1SET (2.3-fold) and returned to resting levels by 29 h post-exercise. However, the exercise induced increase in MPS following 3SET was superior in amplitude and duration as compared to 1SET at both 5 h (3.1-fold above rest) and 29 h post-exercise (2.3-fold above rest). Phosphorylation of 70 kDa S6 protein kinase (p70S6K) demonstrated a coordinated increase with MPS at 5 h and 29 h post-exercise such that the extent of p70S6K phosphorylation was related to the MPS response (r=0.338, P=0.033). Phosphorylation of 90 kDa ribosomal S6 protein kinase (p90RSK) and ribosomal protein S6 (rps6) was similar for 1SET and 3SET at 24 h Fast and 29 h Fed, respectively. However, 3SET induced a greater activation of eukaryotic translation initiation factor 2B (eIF2B) and rpS6 at 5 h Fed. These data suggest that 3SET of resistance exercise is more anabolic than 1SET and may lead to greater increases in myofibrillar protein accretion over time.
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Cites
Progression Models in Resistance Training for Healthy Adults
(2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181915670 · Cited by 4,332 · cited 2×
“inducing gains in muscle size and strength are equivocal (Krieger, 2009, 2010; Ratamess et al. 2009; Winett et al. 2009).”
BackgroundInfluentialProgression Models in Resistance Training for Healthy Adults
(2002) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200202000-00027 · Cited by 2,979
Neural adaptation to resistance training
SALE, D. G. (1988) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-198810001-00009 · Cited by 1,421
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Self-citationMoore, D. R., Robinson, M. J., Fry, J. L., Tang, J. E., Glover, E. I., Wilkinson, S. B., Prior, T., Tarnopolsky, M. A., & Phillips, S. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26401 · Cited by 973
Self-citationKumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740
Drummond, M. J., Fry, C. S., Glynn, E. L., Dreyer, H. C., Dhanani, S., Timmerman, K. L., Volpi, E., & Rasmussen, B. B. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.163816 · Cited by 439 · cited 4×
“…protein synthesis (Phillips et al. 1997), and that anabolic signalling molecule activation is related to (Kumar et al. 2008) and/or required for (Drummond et al. 2009) muscle protein synthesis, we hypothesized that 3SET would induce a greater increase in MPS in both amplitude and duration…”
BackgroundInfluentialBurd, N. A., Tang, J. E., Moore, D. R., & Phillips, S. M. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91351.2008 · Cited by 390
Self-citationResistance training reduces the acute exercise-induced increase in muscle protein turnover
Phillips, S. M., Tipton, K. D., Ferrando, A. A., & Wolfe, R. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.276.1.e118 · Cited by 336
Self-citationWest, D. W. D., Burd, N. A., Tang, J. E., Moore, D. R., Staples, A. W., Holwerda, A. M., Baker, S. K., & Phillips, S. M. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01147.2009 · Cited by 290 · cited 1×
“The recruitment of type II fibres is important in eliciting maximal adaptations to resistance exercise, as these fibres are highly responsive, and more so than type I fibres, to resistance training insofar as muscle hypertrophy is concerned (McCall et al. 1996; West et al. 2010).”
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Cited by
Schoenfeld, B. J., Ogborn, D., & Krieger, J. W. (2017) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1210197 · Cited by 671
Resistance exercise load does not determine training-mediated hypertrophic gains in young men
Mitchell, C. J., Churchward-Venne, T. A., West, D. W. D., Burd, N. A., Breen, L., Baker, S. K., & Phillips, S. M. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00307.2012 · Cited by 627
Self-citationBurd, N. A., West, D. W. D., Staples, A. W., Atherton, P. J., Baker, J. M., Moore, D. R., Holwerda, A. M., Parise, G., Rennie, M. J., Baker, S. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012033 · Cited by 531
Self-citationAreta, J. L., Burke, L. M., Ross, M. L., Camera, D. M., West, D. W. D., Broad, E. M., Jeacocke, N. A., Moore, D. R., Stellingwerff, T., Phillips, S. M., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.244897 · Cited by 495
Self-citationYang, Y., Breen, L., Burd, N. A., Hector, A. J., Churchward-Venne, T. A., Josse, A. R., Tarnopolsky, M. A., & Phillips, S. M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511007422 · Cited by 480
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Metadata
- Authors
- Burd, N. A., Holwerda, A. M., Selby, K. C., West, D. W. D., Staples, A. W., Cain, N. E., Cashaback, J. G. A., Potvin, J. R., Baker, S. K., & Phillips, S. M.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2010-08-13
- Volume
- 588
- Issue
- 16
- Pages
- 3119-3130
- ISSN
- 0022-3751 (ISSN-L)
- OpenAlex
- W1607703564
- Cited by
- 317
- References
- 18
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Burd, N. A., Holwerda, A. M., Selby, K. C., West, D. W. D., Staples, A. W., Cain, N. E., Cashaback, J. G. A., Potvin, J. R., Baker, S. K., & Phillips, S. M. (2010). Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men: Resistance exercise volume and myofibrillar protein synthesis. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2010.192856
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