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Cited by 317

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men: Resistance exercise volume and myofibrillar protein synthesis

Open access
Burd, Nicholas A., Holwerda, Andrew M., Selby, Keegan C., West, Daniel W. D., Staples, Aaron W., Cain, Nathan E., Cashaback, Joshua G. A., Potvin, James R., Baker, Steven K., Phillips, Stuart M.·2010·The Journal of Physiology
DOI 10.1113/jphysiol.2010.192856
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Abstract

We aimed to determine if any mechanistic differences exist between a single set (1SET) and multiple sets (i.e. 3 sets; 3SET) of resistance exercise by utilizing a primed constant infusion of [ring-13C6]phenylalanine to determine myofibrillar protein synthesis (MPS) and Western blot analysis to examine anabolic signalling molecule phosphorylation following an acute bout of resistance exercise. Eight resistance-trained men (24+/-5 years, BMI=25+/-4 kg m2) were randomly assigned to perform unilateral leg extension exercise at 70% concentric one repetition maximum (1RM) until volitional fatigue for 1SET or 3SET. Biopsies from the vastus lateralis were taken in the fasted state (Fast) and fed state (Fed; 20 g of whey protein isolate) at rest, 5 h Fed, 24 h Fast and 29 h Fed post-exercise. Fed-state MPS was transiently elevated above rest at 5 h for 1SET (2.3-fold) and returned to resting levels by 29 h post-exercise. However, the exercise induced increase in MPS following 3SET was superior in amplitude and duration as compared to 1SET at both 5 h (3.1-fold above rest) and 29 h post-exercise (2.3-fold above rest). Phosphorylation of 70 kDa S6 protein kinase (p70S6K) demonstrated a coordinated increase with MPS at 5 h and 29 h post-exercise such that the extent of p70S6K phosphorylation was related to the MPS response (r=0.338, P=0.033). Phosphorylation of 90 kDa ribosomal S6 protein kinase (p90RSK) and ribosomal protein S6 (rps6) was similar for 1SET and 3SET at 24 h Fast and 29 h Fed, respectively. However, 3SET induced a greater activation of eukaryotic translation initiation factor 2B (eIF2B) and rpS6 at 5 h Fed. These data suggest that 3SET of resistance exercise is more anabolic than 1SET and may lead to greater increases in myofibrillar protein accretion over time.

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Metadata

Authors
Burd, N. A., Holwerda, A. M., Selby, K. C., West, D. W. D., Staples, A. W., Cain, N. E., Cashaback, J. G. A., Potvin, J. R., Baker, S. K., & Phillips, S. M.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2010-08-13
Volume
588
Issue
16
Pages
3119-3130
ISSN
0022-3751 (ISSN-L)
DOI
10.1113/jphysiol.2010.192856
OpenAlex
W1607703564
Cited by
317
References
18
FWCI
7.85
Type
journal article
Language
en
Open access
green

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