The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The role of fructose transporters in diseases linked to excessive fructose intake
Open accessAbstract
Fructose intake has increased dramatically since humans were hunter‐gatherers, probably outpacing the capacity of human evolution to make physiologically healthy adaptations. Epidemiological data indicate that this increasing trend continued until recently. Excessive intakes that chronically increase portal and peripheral blood fructose concentrations to >1 and 0.1 m m, respectively, are now associated with numerous diseases and syndromes. The role of the fructose transporters GLUT5 and GLUT2 in causing, contributing to or exacerbating these diseases is not well known. GLUT5 expression seems extremely low in neonatal intestines, and limited absorptive capacities for fructose may explain the high incidence of malabsorption in infants and cause problems in adults unable to upregulate GLUT5 levels to match fructose concentrations in the diet. GLUT5‐ and GLUT2‐mediated fructose effects on intestinal electrolyte transporters, hepatic uric acid metabolism, as well as renal and cardiomyocyte function, may play a role in fructose‐induced hypertension. Likewise, GLUT2 may contribute to the development of non‐alcoholic fatty liver disease by facilitating the uptake of fructose. Finally, GLUT5 may play a role in the atypical growth of certain cancers and fat tissues. We also highlight research areas that should yield information needed to better understand the role of these GLUTs in fructose‐induced diseases.
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Cites
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“Consumption of 65% fructose pellets by young rats results in 26 mM fructose concentrations in the intestinal lumen, although luminal sugar concentrations in the gut are known to increase dramatically at night (up to an average of ∼100 mM) when rats eat (Ferraris et al. 1990; Jiang & Ferraris, 2001).”
BackgroundInfluentialSelf-citationIncomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.
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Review article: the diagnosis and management of food allergy and food intolerances
Turnbull, J. L., Adams, H. N., & Gorard, D. A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12984 · Cited by 306
Glucose transporters in the small intestine in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02439-5 · Cited by 290
Intestinal Absorption of Fructose
Ferraris, R. P., Choe, J.-Y., & Patel, C. R. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051707 · Cited by 180
Self-citationMastrocola, R., Ferrocino, I., Liberto, E., Chiazza, F., Cento, A. S., Collotta, D., Querio, G., Nigro, D., Bitonto, V., Cutrin, J. C., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.003 · Cited by 68
Fructose metabolism and noncommunicable diseases: recent findings and new research perspectives
Tappy, L. (2018) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000460 · Cited by 37
Fructose Metabolism from a Functional Perspective: Implications for Athletes
Tappy, L., & Rosset, R. (2017) · Sports Medicine · doi:10.1007/s40279-017-0692-4 · Cited by 29
Metadata
- Authors
- Douard, V., & Ferraris, R. P.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2012-12-17
- Volume
- 591
- Issue
- 2
- Pages
- 401-414
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1557716110
- Cited by
- 185
- References
- 9
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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