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Cited by 189Diet, Metabolism, and DiseaseGastrointestinal motility and disordersDigestive system and related health

Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose.

Truswell, AS, Seach, JM, Thorburn, AW·1988·The American Journal of Clinical Nutrition
DOI 10.1093/ajcn/48.6.1424
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Abstract

Small-intestinal absorption of fructose was investigated in healthy human subjects by sequential breath-hydrogen measurements. Fifty-eight percent of 103 subjects produced greater than 20 microL H2/L after consuming 50 g pure fructose in water. About half of those who absorbed fructose incompletely (incomplete absorbers) had abdominal symptoms. Malabsorption of medium doses of pure fructose may therefore be common in man. When 25 g pure fructose was consumed, only 19% of 21 poor absorbers (of 50 g fructose) still produced excess breath H2. When glucose was taken with fructose, the frequency and amount of excessive breath H2 was substantially reduced. This facilitating phenomenon is not generally known but is important because in natural foods fructose occurs in association or in combination (as sucrose) with glucose. Plasma fructose responses were not lower in poor absorbers presumably because these responses depend more on how much fructose passes through the liver than on how much is absorbed.

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Crossref · 10.1093/ajcn/48.6.1424

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  • Ingestion of large amounts of fructose alone causes gastrointestinal distress, and the capacity for intestinal absorption of fructose ingested alone is limited.

    “Furthermore, ingestion of large amounts of fructose (alone) has been reported to cause gastrointestinal distress, and the capacity for intestinal absorption of fructose ingested alone has also been shown to be limited (Truswell et al. 1988; Fujisawa et al. 1993).”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Truswell et al. 1988

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Authors
Truswell, A., Seach, J., & Thorburn, A.
Affiliations
The University of Sydney (AU)
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
1988-12
Volume
48
Issue
6
Pages
1424-1430
ISSN
0002-9165 (ISSN-L)
DOI
10.1093/ajcn/48.6.1424
OpenAlex
W1900840642
Cited by
189
References
21
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 10 · 2020: 3 · 2019: 7 · 2018: 9 · 2017: 14 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 12 · 2012: 3
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Digestive system and related health
Keywords
fructose malabsorption, fructose absorption, breath hydrogen, small intestine, sucrose, abdominal symptoms, healthy volunteers
MeSH terms
Adult, Aged, Blood Glucose, Breath Tests, Female, Fructose, Glucose, Humans, Intestinal Absorption, Intestine, Small, Male, Middle Aged, Reference Values

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