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Raman microscopy for dynamic molecular imaging of living cells
Open accessAbstract
We demonstrate dynamic imaging of molecular distribution in unstained living cells using Raman scattering. By combining slit-scanning detection and optimizing the excitation wavelength, we imaged the dynamic molecular distributions of cytochrome c, protein beta sheets, and lipids in unstained HeLa cells with a temporal resolution of 3 minutes. We found that 532-nm excitation can be used to generate strong Raman scattering signals and to suppress autofluorescence that typically obscures Raman signals. With this technique, we reveal time-resolved distributions of cytochrome c and other biomolecules in living cells in the process of cytokinesis without the need for fluorescent labels or markers.
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Cited by
Gold Nanomaterials at Work in Biomedicine
Yang, X., Yang, M., Pang, B., Vara, M., & Xia, Y. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00193 · Cited by 1,162
Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells
Yamakoshi, H., Dodo, K., Palonpon, A., Ando, J., Fujita, K., Kawata, S., & Sodeoka, M. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308529n · Cited by 461
Self-citationRaman and SERS microscopy for molecular imaging of live cells
Palonpon, A. F., Ando, J., Yamakoshi, H., Dodo, K., Sodeoka, M., Kawata, S., & Fujita, K. (2013) · Nature Protocols · doi:10.1038/nprot.2013.030 · Cited by 377
Self-citationImaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy
Yamakoshi, H., Dodo, K., Okada, M., Ando, J., Palonpon, A., Fujita, K., Kawata, S., & Sodeoka, M. (2011) · Journal of the American Chemical Society · doi:10.1021/ja108404p · Cited by 356
Self-citationKang, J. W., So, P. T. C., Dasari, R. R., & Lim, D.-K. (2015) · Nano Letters · doi:10.1021/nl504444w · Cited by 299
Metadata
- Authors
- Hamada, K., Fujita, K., Smith, N. I., Kobayashi, M., Inouye, Y., & Kawata, S.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2008-07-01
- Volume
- 13
- Issue
- 04
- Pages
- 1
- ISSN
- 1083-3668 (ISSN-L)
- OpenAlex
- W2050103929
- Cited by
- 316
- References
- 0
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hamada, K., Fujita, K., Smith, N. I., Kobayashi, M., Inouye, Y., & Kawata, S. (2008). Raman microscopy for dynamic molecular imaging of living cells. Journal of Biomedical Optics. https://doi.org/10.1117/1.2952192
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
