In vivo reflectance-mode confocal microscopy assessments: Impact of overweight on human skin microcirculation and histomorphology
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Reflectance-mode confocal microscopy (RCM) enables in vivo assessment of the human skin. Impact of overweight on both human skin microcirculation and histomorphology has not been investigated in vivo. The purpose of this study is to evaluate both microcirculation and histomorphology in vivo in overweight. In 10 normotensive overweight nondiabetic individuals (OW-group, BMI 29.1 ± 2.7 kg/m(2)) and 10 age- and sex-matched healthy lean controls (CO-group, BMI 20.4 ± 1.9 kg/m(2)) the following parameters were evaluated using RCM: dermal blood cell flow (DBCF), density of dermal capillaries (DDC), epidermal thickness (ET), and epidermal cell size (ECS). DBCF was counted at 63.11 ± 4.14 cells/min in OW-group and at 51.06 ± 3.84 cells/min in CO-group (P < 0.05). DDC was reduced in OW-group (4.91 ± 0.39 capillaries/mm(2)) compared to the controls (6.02 ± 0.64 capillaries/mm(2), P < 0.05). Histometric evaluation of ET reveals thickening in OW-group compared to the CO-group (54.79 ± 4.25 μm versus 44.03 ± 3.11 μm, P < 0.05). ECS differed significantly (P < 0.05) in OW-group (821.3 ± 42.02 μm(2)) compared to the controls (772.6 ± 34.79 μm(2)). Inverse correlation of dermal capillary density and overweight point to reduced total tissue perfusion while positive related blood cell flow reveals vasodilatation. Increase of both ET and cell size indicates remodeling of cutaneous histomorphology, maybe as an early stage of adiposity-related skin condition.
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Individuals with obesity experience increased cutaneous blood flow to meet the oxygenation needs of tissue, but the blood flow of adipose tissue generally decreases with obesity both after a meal and during a fasting state.
“Individuals with obesity experience increased cutaneous blood flow to meet the oxygenation needs of tissue. However, the blood flow of adipose tissue generally decreases with obesity both after a meal and during a fasting state [61,72].”
From Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring (2021) · cites this paper as [72]
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- Ahmet A. Altintas is currently working as plastic, reconstructive, and hand surgeon at the Medical Center Cologne in Cologne, Germany. He studied medicine at Ruhr University of Bochum/Germany with periods in the University of Essen, Germany, and the University of Istanbul, Turkey. He received his medical doctor degree at the University of Heidelberg, Germany. His research interests include noninvasive imaging, content-based image retrieval, and angiogene- sis induction. Journal of Biomedical Optics 036009-4 March 2016 • Vol. 21
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Sources of inaccuracy in photoplethysmography for continuous cardiovascular monitoring
Fine, J., Branan, K. L., Rodriguez, A. J., Boonya-ananta, T., Ajmal, Ramella-Roman, J. C., McShane, M. J., & Coté, G. L. (2021) · Biosensors · doi:10.3390/bios11040126 · Cited by 348 · see citing works
- Authors
- Altintas, A. A., Aust, M. C., Krämer, R., Vogt, P. M., & Altintas, M. A.
- Affiliations
- University Hospital Cologne (DE)
- Johanniter-Krankenhaus Bonn (DE)
- University Hospital Schleswig-Holstein (DE)
- Medizinische Hochschule Hannover (DE)
- Bergmannsheil Buer
- ORCID
- Vogt, Peter M.
- Venue
- Journal of Biomedical Optics
- Publisher
- SPIE-Intl Soc Optical Eng
- Published
- 2016-03-28
- Volume
- 21
- Issue
- 03
- Pages
- 1-5
- ISSN
- 1083-3668 (ISSN-L)
- 1560-2281
- OpenAlex
- W2316284708
- Cited by
- 10
- References
- 23
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Biomedical Optics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- overweight, obesity, skin microcirculation, epidermal thickness, epidermal cell size, skin histomorphology, tissue perfusion, vasodilation
- MeSH terms
- Adult, Female, Humans, Male, Microcirculation, Middle Aged, Skin, Microscopy, Confocal, Overweight
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