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Effects of Resveratrol in Patients with Type 2 Diabetes Mellitus on Skeletal Muscle SIRT1 Expression and Energy Expenditure
Abstract
OBJECTIVES: The primary aims of the study were to examine the effect of resveratrol on skeletal muscle SIRT1 expression and energy expenditure in subjects with Type 2 diabetes mellitus (T2DM). BACKGROUND: Animal and in vivo studies indicate that resveratrol increases SIRT1 expression that stimulates PGC1α activity. Subsequent upregulation of AMPK and GLUT4 expression are associated with improved insulin sensitivity in peripheral tissues. METHODS: Ten subjects with T2DM were randomized in a double-blind fashion to receive 3g resveratrol or placebo daily for 12 weeks. Secondary outcomes include measures of AMPK, p-AMPK and GLUT4 expression levels, energy expenditure, physical activity levels, distribution of abdominal adipose tissue and skeletal muscle fiber type composition, body weight, HbA1c, plasma lipid subfraction, adiponectin levels, and insulin sensitivity. RESULTS: There was a significant increase in both SIRT1 expression (2.01 vs. 0.86 arbitrary units [AU], p = .016) and p-AMPK to AMPK expression ratio (2.04 vs. 0.79 AU, p = .032) in the resveratrol group compared with the placebo group. Although the percentage of absolute change (8.6 vs. -13.9%, p = .033) and percentage of predicted resting metabolic rate (RMR; 7.8 vs. -13.9%, p = .013) were increased following resveratrol, there was a significant reduction in average daily activity (-38 vs. 43.2%, p = .028) and step counts (-39.5 vs. 11.8%, p = .047) when compared with placebo. CONCLUSIONS: In patients with T2DM, treatment with resveratrol regulates energy expenditure through increased skeletal muscle SIRT1 and AMPK expression. These findings indicate that resveratrol may have beneficial exercise-mimetic effects in patients with T2DM.
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“In these studies, treatment with resveratrol has proved to activate both fuel-sensors AMPK and sirtuin 1 in insulin-sensitive peripheral tissues, especially skeletal muscles.”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [150]
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Huo, R., Huang, X., Yang, Y., Yang, Y., & Lin, J.-Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1139460 · Cited by 23
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“Preliminary clinical trials also show that resveratrol decreases insulin resistance in T2D patients, and they appear to be linked to changes in SIRT1 and AMPK [33–36], which therefore improves glycemic control.”
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“It was reported that resveratrol supplementation increased the resting metabolic rate through enhancing the expression of skeletal muscle SIRT1 and AMPK in subjects with T2DM [38].”
The Journey of Resveratrol from Vineyards to Clinics
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“In a study, RSV administration increased SIRT1, glucose transporter type 4 (GLUT4), and p-AMPK/AMPK ratio in T2D patients and the upregulation of AMPK and GLUT4 were associated with improved insulin sensitivity in peripheral tissues thereby, regulating energy expenditure in these patients (64).”
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“…of alanine aminotransferase, diarrhea, mild indigestion, mild hypoglycemia and infection (patients with mild cellulitis at the biopsy site) (124,125). although rSV is generally safe, there have been incidents of adverse effects; therefore, more animal and related human studies are needed…”
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“It has a beneficial action, similar to exercise, on the skeletal muscle of patients with T2DM [86] and of rats with suspended hindlimbs [89] thanks to its interaction with the PGC1 α and Sirt-1 pathways.”
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“22 A 2018 trial by Bo et al. also examined the effects of re-sveratrol in people with T2DM.”
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A Novel, Rationally Designed Antioxidant Formulation to Prevent Diabetes-Related Complications
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Modulation of Sirtuin-1 by Resveratrol as a Potential Therapy in Alleviating Metabolic Syndrome
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Herbal Bioactives and Their Role in Modulating Inflammation and Oxidative Stress in Skeletal Muscle
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Metadata
- Authors
- Goh, K. P., Lee, H. Y., Lau, D. P., Supaat, W., Chan, Y. H., & Koh, A. F. Y.
- Affiliations
- Khoo Teck Puat Hospital (SG)
- Venue
- International Journal of Sport Nutrition and Exercise Metabolism
- Publisher
- Human Kinetics
- Published
- 2014-02
- Volume
- 24
- Issue
- 1
- Pages
- 2-13
- ISSN
- 1526-484X (ISSN-L)
- 1543-2742
- OpenAlex
- W2103667012
- Cited by
- 187
- References
- 0
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 12 · 2023: 20 · 2022: 15 · 2021: 24 · 2020: 22 · 2019: 9 · 2018: 17 · 2017: 17 · 2016: 9 · 2015: 10 · 2014: 10
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Medical Research Council
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- resveratrol, type 2 diabetes, SIRT1, AMPK, skeletal muscle, energy expenditure, resting metabolic rate, insulin sensitivity, GLUT4, PGC-1α, physical activity, adiponectin, HbA1c
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Resveratrol, Basal Metabolism, Diabetes Mellitus, Type 2, Double-Blind Method, Energy Metabolism, Physical Exertion, Humans, Insulin Resistance, Male, Middle Aged, Plant Extracts, Rest, Stilbenes, Transcription Factors, Exercise, Muscle, Skeletal, Vitis, Glucose Transporter Type 4, AMP-Activated Protein Kinases, Sirtuin 1
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