CoChat
Sign Up
Cited by 23Biochemical effects in animalsMuscle metabolism and nutritionCardiovascular and exercise physiology

β-Alanine supplementation does not augment the skeletal muscle adaptive response to 6 weeks of sprint interval training

Cochran, Andrew J.R., Percival, Michael E., Thompson, Sara, Gillen, Jenna B., MacInnis, Martin J., Potter, Murray A., Tarnopolsky, Mark A., Gibala, Martin J.·2015·International Journal of Sport Nutrition and Exercise Metabolism
DOI 10.1123/ijsnem.2015-0046
Open this paper in CoChat — free account

Abstract

Sprint interval training (SIT), repeated bouts of high-intensity exercise, improves skeletal muscle oxidative capacity and exercise performance. β-alanine (β-ALA) supplementation has been shown to enhance exercise performance, which led us to hypothesize that chronic β-ALA supplementation would augment work capacity during SIT and augment training-induced adaptations in skeletal muscle and performance. Twenty-four active but untrained men (23 ± 2 yr; VO2peak = 50 ± 6 mL · kg(-1) · min(-1)) ingested 3.2 g/day of β-ALA or a placebo (PLA) for a total of 10 weeks (n = 12 per group). Following 4 weeks of baseline supplementation, participants completed a 6-week SIT intervention. Each of 3 weekly sessions consisted of 4-6 Wingate tests, i.e., 30-s bouts of maximal cycling, interspersed with 4 min of recovery. Before and after the 6-week SIT program, participants completed a 250-kJ time trial and a repeated sprint test. Biopsies (v. lateralis) revealed that skeletal muscle carnosine content increased by 33% and 52%, respectively, after 4 and 10 weeks of β-ALA supplementation, but was unchanged in PLA. Total work performed during each training session was similar across treatments. SIT increased markers of mitochondrial content, including cytochome c oxidase (40%) and β-hydroxyacyl-CoA dehydrogenase maximal activities (19%), as well as VO2peak (9%), repeated-sprint capacity (5%), and 250-kJ time trial performance (13%), but there were no differences between treatments for any measure (p < .01, main effects for time; p > .05, interaction effects). The training stimulus may have overwhelmed any potential influence of β-ALA, or the supplementation protocol was insufficient to alter the variables to a detectable extent.

Integrity signals

Registry

Crossref · 10.1123/ijsnem.2015-0046

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There are data to suggest that β-alanine supplementation alongside training may, but not always, augment training adaptations over simply training alone.

    “There are also data to suggest that β-alanine supplementation alongside training may, but not always [217], augment training adaptations over simply training alone [218].”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [217]

Cites

Still being checked.

Cited by

Sorted by citations

Related

Authors
Cochran, A. J. R., Percival, M. E., Thompson, S., Gillen, J. B., MacInnis, M. J., Potter, M. A., Tarnopolsky, M. A., & Gibala, M. J.
Affiliations
McMaster University (CA)
ORCID
Venue
International Journal of Sport Nutrition and Exercise Metabolism
Publisher
Human Kinetics
Published
2015-12
Volume
25
Issue
6
Pages
541-549
ISSN
  • 1526-484X (ISSN-L)
  • 1543-2742
DOI
10.1123/ijsnem.2015-0046
OpenAlex
W371301222
Cited by
23
References
0
Citations by year
2026: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4
FWCI
2.46
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Nestec
  • Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
beta-alanine supplementation, sprint interval training, skeletal muscle adaptation, carnosine, mitochondrial content, cytochrome c oxidase, beta-hydroxyacyl-CoA dehydrogenase, peak oxygen uptake, time trial performance, untrained men, high-intensity exercise
MeSH terms
Adaptation, Physiological, Adult, Carnosine, Double-Blind Method, Exercise Test, Humans, Male, Mitochondria, Oxygen Consumption, beta-Alanine, Exercise, Muscle, Skeletal, Dietary Supplements, Young Adult, Sports Nutritional Physiological Phenomena, Physical Conditioning, Human

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review