Contribution of Nonesterified Fatty Acids to Mitogen-Activated Protein Kinase Activation in Human Skeletal Muscle During Endurance Exercise

Zbinden-Foncea, Hermann; van Loon, Luc J. C.; Raymackers, Jean-Marc; Francaux, Marc; Deldicque, Louise

doi:10.1123/ijsnem.23.3.201

Cited by 12Exercise and Physiological ResponsesCardiovascular and exercise physiologyMuscle metabolism and nutrition

Contribution of Nonesterified Fatty Acids to Mitogen-Activated Protein Kinase Activation in Human Skeletal Muscle During Endurance Exercise

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Zbinden-Foncea, Hermann, van Loon, Luc J. C., Raymackers, Jean-Marc, Francaux, Marc, Deldicque, Louise·2013·International Journal of Sport Nutrition and Exercise Metabolism

DOI 10.1123/ijsnem.23.3.201

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Abstract

Mitogen-activated protein kinase (MAPK) pathways are activated in skeletal muscle during endurance exercise, but the upstream molecular events are incompletely resolved. As an increase in plasma nonesterified fatty acids (NEFA) is a common feature of long-lasting exercise, the authors tested the hypothesis that NEFA contribute to the activation of MAPK during endurance exercise. Acipimox was used before and during endurance exercise to prevent the elevation of plasma NEFA levels in healthy subjects and patients with diabetes. In 2 separate studies, healthy subjects cycled for 2 hr and patients with diabetes for 1 hr at 50% W max. In control conditions, plasma NEFA concentrations increased from 0.35 to 0.90 mM during exercise in healthy subjects and from 0.55 to 0.70 mM in patients with diabetes (p < .05). Phosphorylation states of extracellularly regulated kinase 1 and 2 (ERK1/2), p38, and c-Jun NH 2-terminal kinases (JNK) were significantly increased after exercise in the vastus lateralis in both groups. Acipimox blocked the increase in plasma NEFA concentrations and almost completely repressed any rise in ERK1/2 and p38 but not in JNK. In conclusion, the data support a role for plasma NEFA in the activation of p38 and ERK1/2 in skeletal-muscle tissue of healthy and diabetic subjects during endurance exercise. Further investigation will be required to determine the molecular link between NEFA and MAPK activation during exercise in human skeletal muscle.

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Exercise-induced activation of p38MAPK is suppressed with pharmacological ablation of FFA availability.
“Indeed, the exercise-induced activation of p38MAPK is suppressed with pharmacological ablation of FFA availability [42].”
From Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis (2018) · cites this paper as [42]

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Fuel for the Work Required: A Theoretical Framework for Carbohydrate Periodization and the Glycogen Threshold Hypothesis
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“Indeed, the exercise-induced activation of p38MAPK is suppressed with pharmacological ablation of FFA availability [42].”
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Authors: Zbinden-Foncea, H., van Loon, L. J. C., Raymackers, J.-M., Francaux, M., & Deldicque, L.
Affiliations: UCLouvain (BE)
KU Leuven (BE)
ORCID: Raymackers, Jean-Marc
Francaux, Marc
Deldicque, Louise
Venue: International Journal of Sport Nutrition and Exercise Metabolism
Publisher: Human Kinetics
Published: 2013-06
Volume: 23
Issue: 3
Pages: 201-209
ISSN: 1526-484X (ISSN-L)
1543-2742
DOI: 10.1123/ijsnem.23.3.201
OpenAlex: W1820860568
Cited by: 12
References: 43
Citations by year: 2026: 1 · 2024: 1 · 2023: 2 · 2020: 2 · 2018: 2 · 2016: 1 · 2014: 3
FWCI: 1.42
Type: journal article
Language: en
Open access: green
lirias.kuleuven.be
Licence: other-oa
Locations: International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion)
Lirias (acceptedVersion, other-oa)
Research Bank (Australian Catholic University) (submittedVersion)
DIAL (Catholic University of Leuven) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords: free fatty acids, mitogen-activated protein kinase, endurance exercise, skeletal muscle, acipimox, ERK1/2, p38 MAPK, JNK, diabetes mellitus, plasma free fatty acids, vastus lateralis
MeSH terms: Hypolipidemic Agents, Diabetes Mellitus, Fatty Acids, Nonesterified, Humans, Male, Middle Aged, Phosphorylation, Physical Endurance, Pyrazines, Exercise, Muscle, Skeletal, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, Young Adult, Sedentary Behavior

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Contribution of Nonesterified Fatty Acids to Mitogen-Activated Protein Kinase Activation in Human Skeletal Muscle During Endurance Exercise

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