Systemic IL-6 and Myoglobin Response to Three Different Resistance Exercise Intensities in Older Men
Abstract
The purpose of this research was to identify if three different intensities of resistance exercise would acutely and differentially effect the systemic release of interleukin-6 (IL-6) and myoglobin in older men (≥65 years). A total of 11 older men performed isovolume resistance exercise on six different apparatuses at three different intensities (144 reps at 60%, 120 reps at 72%, and 108 reps at 80% of 1-repetition maximum), with the intensity order randomly allocated, to determine the systemic release of IL-6 and myoglobin in the blood. Blood samples were collected at six time points, including preexercise, immediately postexercise, and 3, 6, 24, and 48 hr postexercise. There were no differences between intensity levels; therefore, data for all conditions were pooled. IL-6 did not show any change from baseline values throughout all time points (p > .05), whereas myoglobin was elevated at 3, 6, and 24 hr postexercise and returned to baseline after 48 hr (p < .05).
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Resistance training also increases circulating IL-6, though some studies suggest that IL-6 responses to resistance training may be less sensitive to intensity variations.
“Resistance training also increases circulating IL-6, though some studies suggest that IL-6 responses to resistance training may be less sensitive to intensity variations [12,13].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [13]
HIIT induces an extremely rapid and sharp peak in IL-6 release.
“High-intensity interval training (HIIT), due to its intense metabolic stress, induces an extremely rapid and sharp peak in IL-6 release [12,13].”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [13]
Prolonged moderate-intensity training induces a more persistent IL-6 release pattern and effectively modulates FGF21 signaling, enhancing tissue sensitivity and reversing FGF21 resistance.
“Prolonged moderate-intensity training induces a more persistent IL-6 release pattern [12,13] and effectively modulates FGF21 signaling, enhancing tissue sensitivity and reversing FGF21 resistance.”
From Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review (2026) · cites this paper as [13]
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Kwon, J. H., Moon, K. M., & Min, K.-W. (2020) · Healthcare · doi:10.3390/healthcare8040378 · Cited by 116 · see citing works
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- Authors
- Cornish, S. M., Chase, J. E., Bugera, E. M., & Giesbrecht, G. G.
- Corresponding author
- Cornish, Stephen M.
- Venue
- Journal of Aging and Physical Activity
- Publisher
- Human Kinetics
- Published
- 2018-07-01
- Volume
- 26
- Issue
- 3
- Pages
- 451-456
- ISSN
- 1063-8652 (ISSN-L)
- 1543-267X
- OpenAlex
- W2765539135
- Cited by
- 15
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Aging and Physical Activity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- interleukin-6, myoglobin, resistance training, exercise intensity, older men, aging, acute exercise response, post-exercise recovery, cytokines, muscle damage markers
- MeSH terms
- Aged, Humans, Male, Myoglobin, Interleukin-6, Resistance Training
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