Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview
Open accessAbstract
Physical activity has been found to aid the maintenance of health in the elderly. Exercise-induced skeletal muscle contractions lead to the production and secretion of many small proteins and proteoglycan peptides called myokines. Thus, studies on myokines are necessary for ensuring the maintenance of skeletal muscle health in the elderly. This review summarizes 13 myokines regulated by physical activity that are affected by aging and aims to understand their potential roles in metabolic diseases. We categorized myokines into two groups based on regulation by aerobic and anaerobic exercise. With aging, the secretion of apelin, β-aminoisobutyric acid (BAIBA), bone morphogenetic protein 7 (BMP-7), decorin, insulin-like growth factor 1 (IGF-1), interleukin-15 (IL-15), irisin, stromal cell-derived factor 1 (SDF-1), sestrin, secreted protein acidic rich in cysteine (SPARC), and vascular endothelial growth factor A (VEGF-A) decreased, while that of IL-6 and myostatin increased. Aerobic exercise upregulates apelin, BAIBA, IL-15, IL-6, irisin, SDF-1, sestrin, SPARC, and VEGF-A expression, while anaerobic exercise upregulates BMP-7, decorin, IGF-1, IL-15, IL-6, irisin, and VEGF-A expression. Myostatin is downregulated by both aerobic and anaerobic exercise. This review provides a rationale for developing exercise programs or interventions that maintain a balance between aerobic and anaerobic exercise in the elderly.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Apelin is pointed out as a biomarker of early sarcopenia.
“Therefore, this myokine is also pointed out as a biomarker of early sarcopenia [58].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [58]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,529 · see citing works
Vascular Endothelial Growth Factor Is a Secreted Angiogenic Mitogen
Leung, D. W., Cachianes, G., Kuang, W.-J., Goeddel, D. V., & Ferrara, N. (1989) · Science · doi:10.1126/science.2479986 · Cited by 4,988 · see citing works
Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1997) · Nature · doi:10.1038/387083a0 · Cited by 4,013 · see citing works
Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid
Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969 · see citing works
Muscles, exercise and obesity: skeletal muscle as a secretory organ
Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.49 · Cited by 2,909 · see citing works
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews · doi:10.1152/physrev.90100.2007 · Cited by 2,388 · see citing works
Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature · doi:10.1038/324073a0 · Cited by 2,139 · see citing works
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953 · see citing works
Chen, D., Zhao, M., & Mundy, G. R. (2004) · Growth Factors · doi:10.1080/08977190412331279890 · Cited by 1,921 · see citing works
Active Ageing: A Policy Framework
Kalache, A., & Gatti, A. (2002) · The Aging Male · doi:10.1080/713604647 · Cited by 1,764 · see citing works
Skeletal muscle: A brief review of structure and function
Frontera, W. R., & Ochala, J. (2015) · Calcified Tissue International · doi:10.1007/s00223-014-9915-y · Cited by 1,758 · see citing works
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.-X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9489 · Cited by 1,684 · see citing works
Lautenschlager, N. T., Cox, K. L., Flicker, L., Foster, J. K., van Bockxmeer, F. M., Xiao, J., Greenop, K. R., & Almeida, O. P. (2008) · JAMA · doi:10.1001/jama.300.9.1027 · Cited by 1,637 · see citing works
Active Ageing: A Policy Framework
(2002) · The Aging Male · doi:10.1080/tam.5.1.1.37 · Cited by 1,567 · see citing works
Rinderknecht, E., & HUMBEL, R. E. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40889-1 · Cited by 1,548 · see citing works
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
Moore, S. C., Lee, I.-M., Weiderpass, E., Campbell, P. T., Sampson, J. N., Kitahara, C. M., Keadle, S. K., Arem, H., Berrington de Gonzalez, A., Hartge, P., et al. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.1548 · Cited by 1,487 · see citing works
Cloning of a T Cell Growth Factor that Interacts with the β Chain of the Interleukin-2 Receptor
Grabstein, K. H., Eisenman, J. R., Shanebeck, K. D., Rauch, C. T., Srinivasan, S., Fung, V., Beers, C., Richardson, J. S., Schoenborn, M. A., Ahdieh, M., et al. (1994) · Science · doi:10.1126/science.8178155 · Cited by 1,422 · see citing works
Mitchell, W. K., Williams, J., Atherton, P., Larvin, M., Lund, J., & Narici, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00260 · Cited by 1,377 · see citing works
Molecular cloning and expression of an IL-6 signal transducer, gp130
Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., & Kishimoto, T. (1990) · Cell · doi:10.1016/0092-8674(90)90411-7 · Cited by 1,304 · see citing works
Ray, N. F., Chan, J. K., Thamer, M., & Melton, L. J. (1997) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1997.12.1.24 · Cited by 1,281 · see citing works
Steensberg, A., van Hall, G., Osada, T., Sacchetti, M., Saltin, B., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00237.x · Cited by 1,095 · see citing works
A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro.
SALMON, W. D., & Daughaday, W. H. (1957) · PubMed · Cited by 1,084 · see citing works
Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor
Yamasaki, K., Taga, T., Hirata, Y., Yawata, H., Kawanishi, Y., Seed, B., Taniguchi, T., Hirano, T., & Kishimoto, T. (1988) · Science · doi:10.1126/science.3136546 · Cited by 1,053 · see citing works
Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.002 · Cited by 1,040 · see citing works
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Lourenco, M. V., Frozza, R. L., de Freitas, G. B., Zhang, H., Kincheski, G. C., Ribeiro, F. C., Gonçalves, R. A., Clarke, J. R., Beckman, D., Staniszewski, A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0275-4 · Cited by 935 · see citing works
Blondell, S. J., Hammersley-Mather, R., & Veerman, J. L. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-510 · Cited by 928 · see citing works
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity
Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigné, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpéné, C., et al. (2005) · Endocrinology · doi:10.1210/en.2004-1427 · Cited by 910 · see citing works
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · see citing works
Role of Myokines in Exercise and Metabolism
Pedersen, B. K., Åkerström, T. C. A., Nielsen, A. R., & Fischer, C. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00080.2007 · Cited by 841 · see citing works
Samitz, G., Egger, M., & Zwahlen, M. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr112 · Cited by 836 · see citing works
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
Nagasawa, T., Kikutani, H., & Kishimoto, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2305 · Cited by 817 · see citing works
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Fiuza-Luces, C., Santos-Lozano, A., Joyner, M., Carrera-Bastos, P., Picazo, O., Zugaza, J. L., Izquierdo, M., Ruilope, L. M., & Lucia, A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0065-1 · Cited by 803 · see citing works
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T., & Honjo, T. (1993) · Science · doi:10.1126/science.8342023 · Cited by 712 · see citing works
Roubenoff, R., & HUGHES, V. A. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.m716 · Cited by 687 · see citing works
Characterization of Apelin, the Ligand for the APJ Receptor
Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A., Liu, Y., Osmond, D. H., George, S. R., & O’Dowd, B. F. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0740034.x · Cited by 676 · see citing works
Roberts, L. D., Boström, P., O’Sullivan, J. F., Schinzel, R. T., Lewis, G. D., Dejam, A., Lee, Y.-K., Palma, M. J., Calhoun, S., Georgiadi, A., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.003 · Cited by 643 · see citing works
The vascular endothelial growth factor family of polypeptides
Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., & Leung, D. W. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470305 · Cited by 641 · see citing works
The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism
Tatemoto, K., Takayama, K., Zou, M.-X., Kumaki, I., Zhang, W. Y., KUMANO, K., & Fujimiya, M. (2001) · Regulatory Peptides · doi:10.1016/s0167-0115(01)00236-1 · Cited by 640 · see citing works
Taylor, A. H., Cable, N. T., Faulkner, G., Hillsdon, M. M., Narici, M. V., & Bij, A. V. D. (2004) · Journal of Sports Sciences · doi:10.1080/02640410410001712421 · Cited by 625 · see citing works
Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility
Szokodi, I., Tavi, P., Földes, G., Voutilainen-Myllylä, S., Ilves, M., Tokola, H., Pikkarainen, S., Piuhola, J., Rysä, J., Tóth, M., et al. (2002) · Circulation Research · doi:10.1161/01.res.0000033522.37861.69 · Cited by 625 · see citing works
Structure and Chromosomal Localization of the Human Stromal Cell-Derived Factor 1 (SDF1) Gene
Shirozu, M., Nakano, T., Inazawa, J., Tashiro, K., Tada, H., Shinohara, T., & Honjo, T. (1995) · Genomics · doi:10.1006/geno.1995.1180 · Cited by 624 · see citing works
SPARC, a matricellular protein: at the crossroads of cell–matrix communication
Brekken, R. A., & Sage, E. H. (2001) · Matrix Biology · doi:10.1016/s0945-053x(00)00133-5 · Cited by 587 · see citing works
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T Cells
Klebanoff, C. A., Finkelstein, S. E., Surman, D. R., Lichtman, M. K., Gattinoni, L., Theoret, M. R., Grewal, N. S., Spiess, P. J., Antony, P. A., Palmer, D. C., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307298101 · Cited by 576 · see citing works
Gonzalez-Cadavid, N. F., Taylor, W. E., Yarasheski, K., Sinha-Hikim, I., Ma, K., Ezzat, S., Shen, R., Lalani, R., Asa, S., Mamita, M., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14938 · Cited by 571 · see citing works
OP‐1 cDNA encodes an osteogenic protein in the TGF‐beta family.
Özkaynak, E., Rueger, D. C., Drier, E. A., Corbett, C., Ridge, R. J., Sampath, T. K., & Oppermann, H. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07376.x · Cited by 554 · see citing works
Walking and Leisure-Time Activity and Risk of Hip Fracture in Postmenopausal Women
Feskanich, D. (2002) · JAMA · doi:10.1001/jama.288.18.2300 · Cited by 502 · see citing works
Zilberstein, A., Ruggieri, R., Korn, J. H., & Revel, M. (1986) · The EMBO Journal · doi:10.1002/j.1460-2075.1986.tb04531.x · Cited by 486 · see citing works
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 459 · see citing works
Exercise‐induced increase in serum interleukin‐6 in humans is related to muscle damage.
Brüünsgaard, H., Galbo, H., Halkjær-Kristensen, J., Johansen, T., MacLean, D. A., & Pedersen, B. K. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021972 · Cited by 455 · see citing works
Trombetti, A., Reid, K. F., Hars, M., Herrmann, F. R., Pasha, E. P., Phillips, E. M., & Fielding, R. A. (2015) · Osteoporosis International · doi:10.1007/s00198-015-3236-5 · Cited by 439 · see citing works
Skeletal Muscle as Potential Central Link between Sarcopenia and Immune Senescence
Nelke, C., Dziewas, R., Minnerup, J., Meuth, S. G., & Ruck, T. (2019) · eBioMedicine · doi:10.1016/j.ebiom.2019.10.034 · Cited by 437 · see citing works
The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases
Brandt, C., & Pedersen, B. K. (2010) · BioMed Research International · doi:10.1155/2010/520258 · Cited by 426 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
Sequence of cDNA encoding human insulin-like growth factor I precursor
Jansen, M., van Schaik, F. M. A., Ricker, A. T., et al. (1983) · Nature · doi:10.1038/306609a0 · Cited by 403 · see citing works
Increase of plasma IL-6 concentration with age in healthy subjects
Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90112-3 · Cited by 402 · see citing works
Kurdiova, T., Balaz, M., Vician, M., Maderova, D., Vlcek, M., Valkovic, L., Srbecky, M., Imrich, R., Kyselovicova, O., Belan, V., et al. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.264655 · Cited by 401 · see citing works
Burton, J. D., Bamford, R. N., Peters, C., Grant, A. J., Kurys, G., Goldman, C. K., Brennan, J., Roessler, E., & Waldmann, T. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4935 · Cited by 398 · see citing works
The exerkine apelin reverses age-associated sarcopenia
Vinel, C., Lukjanenko, L., Batut, A., Deleruyelle, S., Pradère, J.-P., Le Gonidec, S., Dortignac, A., Geoffre, N., Pereira, O., Karaz, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0131-6 · Cited by 398 · see citing works
Leal, L. G., Lopes, M. A., & Batista, M. L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01307 · Cited by 382 · see citing works
Beneficial health effects of exercise – the role of IL-6 as a myokine
Pedersen, B. K., & Fischer, C. P. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.02.002 · Cited by 371 · see citing works
Huh, J. Y., Mougios, V., Kabasakalis, A., Fatouros, I., Siopi, A., Douroudos, I. I., Filippaios, A., Panagiotou, G., Park, K. H., & Mantzoros, C. S. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-1437 · Cited by 363 · see citing works
Interleukin-15 biology and its therapeutic implications in cancer
Steel, J. C., Waldmann, T. A., & Morris, J. C. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2011.09.004 · Cited by 361 · see citing works
Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum
Habata, Y., Fujii, R., Hosoya, M., Fukusumi, S., Kawamata, Y., Hinuma, S., Kitada, C., Nishizawa, N., Murosaki, S., Kurokawa, T., et al. (1999) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(99)00114-7 · Cited by 359 · see citing works
Aoi, W., Naito, Y., Takagi, T., Tanimura, Y., Takanami, Y., Kawai, Y., Sakuma, K., Hang, L. P., Mizushima, K., Hirai, Y., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-300776 · Cited by 347 · see citing works
Sestrins Orchestrate Cellular Metabolism to Attenuate Aging
Lee, J. H., Budanov, A. V., & Karin, M. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.018 · Cited by 339 · see citing works
Ouchi, N., Oshima, Y., Ohashi, K., Higuchi, A., Ikegami, C., Izumiya, Y., & Walsh, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803440200 · Cited by 338 · see citing works
(1993) · PubMed · Cited by 330 · see citing works
Zhang, L., Rajan, V. R., Lin, E., Hu, Z., Han, H. Q., Zhou, X., Song, Y., Min, H., Wang, X., Du, J., et al. (2011) · The FASEB Journal · doi:10.1096/fj.10-176917 · Cited by 317 · see citing works
Physical inactivity, excess adiposity and premature mortality
Katzmarzyk, P. T., Janssen, I., & Ardern, C. I. (2003) · Obesity Reviews · doi:10.1046/j.1467-789x.2003.00120.x · Cited by 315 · see citing works
Yarasheski, K. E., Bhasin, S., Sinha‐Hikim, I., Pak-Loduca, J., & González-Cadavid, N. F. (2002) · PubMed · Cited by 293 · see citing works
Gianoudis, J., Bailey, C. A., & Daly, R. M. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2895-y · Cited by 293 · see citing works
Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders
Singh, M. A. F., Ding, W., Manfredi, T., Solares, G. R., O’Neill, E. F., Clements, K. M., Ryan, N. D., Kehayias, J. J., Fielding, R. A., & Evans, W. J. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e135 · Cited by 286 · see citing works
Regulation of Muscle Mass by Follistatin and Activins
Lee, S.-J., Lee, Y.-S., Zimmers, T. A., Soleimani, A., Matzuk, M. M., Tsuchida, K., Cohn, R. D., & Barton, E. R. (2010) · Molecular Endocrinology · doi:10.1210/me.2010-0127 · Cited by 273 · see citing works
Myostatin decreases with aerobic exercise and associates with insulin resistance
HITTEL, D. S., AXELSON, M., SARNA, N., SHEARER, J., HUFFMAN, K. M., & KRAUS, W. E. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181e0b9a8 · Cited by 271 · see citing works
Li, L., Yang, G., Li, Q., Tang, Y., Yang, M., Yang, H., & Li, K. (2006) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2006-948309 · Cited by 268 · see citing works
Mortality as an adverse outcome of sarcopenia
Arango-Lopera, V. E., Arroyo, P., Gutiérrez‐Robledo, L. M., Pérez‐Zepeda, M. U., & Cesari, M. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-012-0434-0 · Cited by 262 · see citing works
Potential Benefits of Physical Activity in MCI and Dementia
Nuzum, H., Stickel, A. M., Corona, M., Zeller, M., Melrose, R. J., & Wilkins, S. S. (2020) · Behavioural Neurology · doi:10.1155/2020/7807856 · Cited by 260 · see citing works
From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation
Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology · doi:10.1038/icb.2014.16 · Cited by 258 · see citing works
Malamut, G., Machhour, R. E., Montcuquet, N., Martin‐Lannerée, S., Dusanter‐Fourt, I., Verkarre, V., Mention, J., Rahmi, G., Kiyono, H., Butz, E. A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41344 · Cited by 256 · see citing works
Regulation of Skeletal Muscle Function by Amino Acids
Kamei, Y., Hatazawa, Y., Uchitomi, R., Yoshimura, R., & Miura, S. (2020) · Nutrients · doi:10.3390/nu12010261 · Cited by 254 · see citing works
Muscle contractions induce interleukin‐6 mRNA production in rat skeletal muscles
Jonsdottir, I. H., Schjerling, P., Ostrowski, S. R., Asp, S., Richter, E. A., & Pedersen, B. K. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00157.x · Cited by 251 · see citing works
Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 249 · see citing works
Contractile C2C12myotube model for studying exercise-inducible responses in skeletal muscle
Nedachi, T., Fujita, H., & Kanzaki, M. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90280.2008 · Cited by 247 · see citing works
SPARC in cancer biology: Its role in cancer progression and potential for therapy
Tai, I. T., & Tang, M. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.08.005 · Cited by 245 · see citing works
Use it or lose it to age: A review of bone and muscle communication
Bonewald, L. F. (2018) · Bone · doi:10.1016/j.bone.2018.11.002 · Cited by 229 · see citing works
Riechman, S. E., Balasekaran, G., Roth, S. M., & Ferrell, R. E. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00491.2004 · Cited by 228 · see citing works
Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., Daviaud, D., Mir, L., Marques, M.-A., Thalamas, C., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2013.158 · Cited by 227 · cited 2× · see citing works
“This was the first study to recognize apelin as a myokine [39].”
BackgroundMethodThe bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
Winbanks, C. E., Chen, J. L., Qian, H., Liu, Y., Bernardo, B. C., Beyer, C., Watt, K. I., Thomson, R. E., Connor, T., Turner, B. J., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211134 · Cited by 225 · see citing works
β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor
Kitase, Y., Vallejo, J. A., Gutheil, W., Vemula, H., Jähn, K., Yi, J., Zhou, J., Brotto, M., & Bonewald, L. F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.041 · Cited by 219 · see citing works
The myokine decorin is regulated by contraction and involved in muscle hypertrophy
Kanzleiter, T., Rath, M., Görgens, S. W., Jensen, J., Tangen, D. S., Kolnes, A. J., Kolnes, K. J., Lee, S., Eckel, J., Schürmann, A., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.06.123 · Cited by 209 · see citing works
Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease
Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B. R., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.023 · Cited by 206 · see citing works
Dunkman, A. A., Buckley, M. R., Mienaltowski, M. J., Adams, S. M., Thomas, S. J., Satchell, L. N., Kumar, A., Pathmanathan, L., Beason, D. P., Iozzo, R. V., et al. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.11.005 · Cited by 204 · see citing works
Budanov, A. V. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3530 · Cited by 203 · see citing works
Lecker, S. H., Zavin, A., Cao, P., Arena, R. A., Allsup, K., Daniels, K. M., Joseph, J., Schulze, P. C., & Forman, D. E. (2012) · Circulation Heart Failure · doi:10.1161/circheartfailure.112.969543 · Cited by 197 · see citing works
Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running
Sprenger, H., Jacobs, C., Nain, M., Gressner, A. M., Prinz, H., Wesemann, W., & Gemsa, D. (1992) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(92)90012-d · Cited by 195 · see citing works
Is physical activity a potential preventive factor for vascular dementia? A systematic review
Aarsland, D., Sardahaee, F. S., Anderssen, S., Ballard, C., & the Alzheimer's Society Systematic Review group (2010) · Aging & Mental Health · doi:10.1080/13607860903586136 · Cited by 195 · see citing works
SPARC: a key player in the pathologies associated with obesity and diabetes
Kos, K., & Wilding, J. P. H. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.18 · Cited by 193 · see citing works
Thigh circumference and risk of heart disease and premature death: prospective cohort study
Heitmann, B. L., & Frederiksen, P. (2009) · BMJ · doi:10.1136/bmj.b3292 · Cited by 186 · see citing works
Ripamonti, U., & Reddi, A. H. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080020401 · Cited by 184 · see citing works
Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes
Teufel, A., Malik, N., Mukhopadhyay, M., & Westphal, H. (2002) · Gene · doi:10.1016/s0378-1119(02)00828-4 · Cited by 183 · see citing works
CXCR4andGab1cooperate to control the development of migrating muscle progenitor cellsPreprint
Vasyutina, E. L., Stebler, J., Brand‐Saberi, B., Schulz, S., Raz, E., & Birchmeier, C. (2005) · Genes & Development · doi:10.1101/gad.346205 · Cited by 182 · see citing works
Kim, H.-J., So, B., Choi, M., Kang, D., & Song, W. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.07.006 · Cited by 181 · see citing works
Crane, J. D., MacNeil, L. G., Lally, J. S., Ford, R. J., Bujak, A. L., Brar, I. K., Kemp, B. E., Raha, S., Steinberg, G. R., & Tarnopolsky, M. A. (2015) · Aging Cell · doi:10.1111/acel.12341 · Cited by 179 · see citing works
Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo
Cui, G., Hara, T., Simmons, S., Wagatsuma, K., Abe, A., Miyachi, H., Kitano, S., Ishii, M., Tani‐ichi, S., & Ikuta, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318281111 · Cited by 179 · see citing works
Identification of human exercise-induced myokines using secretome analysis
Catoire, M., Mensink, M., Kalkhoven, E., Schrauwen, P., & Kersten, S. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00174.2013 · Cited by 179 · see citing works
Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults
Tay, L. B. G., Ding, Y. Y., Leung, B. P. L., Ismail, N. H., Yeo, A., Yew, S., Tay, K. S., Tan, C. H., & Chong, M. S. (2015) · AGE · doi:10.1007/s11357-015-9860-3 · Cited by 174 · see citing works
Interleukin-6 and selected plasma proteins in healthy persons of different ages
Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works
Critchley, M. (1931) · The Lancet · doi:10.1016/s0140-6736(00)90705-0 · Cited by 167 · see citing works
Muscle‐specific VEGF deficiency greatly reduces exercise endurance in mice
Olfert, I. M., Howlett, R. A., Tang, K., Dalton, N. D., Gu, Y., Peterson, K. L., Wagner, P. D., & Breen, E. C. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164384 · Cited by 166 · see citing works
Chang, J. S., Kim, T. H., Nguyen, T. T., Park, K., Kim, N., & Kong, I. D. (2017) · Geriatrics & Gerontology International · doi:10.1111/ggi.13030 · Cited by 166 · see citing works
Aydın, S., Kuloğlu, T., Aydin, S., Eren, M. N., Çelik, A., Yılmaz, M., Kalaycı, M. Z., Şahin, İ., Gungor, O., Gürel, A., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.11.024 · Cited by 165 · see citing works
Lower skeletal muscle capillarization and VEGF expression in aged vs. young men
Ryan, N. A., Zwetsloot, K. A., Westerkamp, L. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00827.2005 · Cited by 165 · see citing works
Fox, J., Rioux, B. V., Goulet, E. D. B., Johanssen, N. M., Swift, D. L., Bouchard, D. R., Loewen, H., & Sénéchal, M. (2018) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12904 · Cited by 161 · see citing works
β-Aminoisobutyric Acid (α-Methyl-β-Alanine): A New Amino-Acid Obtained from Human Urine
Crumpler, H. R., Dent, C. E., Harris, H., et al. (1951) · Nature · doi:10.1038/167307a0 · Cited by 149 · see citing works
Ma, D., Wu, L., & He, Z. (2013) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000000100 · Cited by 148 · see citing works
Brady, A. O., Straight, C. R., & Evans, E. M. (2014) · Journal of Aging and Physical Activity · doi:10.1123/japa.2013-0009 · Cited by 143 · see citing works
Resistance Training Alters Plasma Myostatin but not IGF-1 in Healthy Men
WALKER, K. S., Kambadur, R., Sharma, M., & Smith, H. K. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000126384.04778.29 · Cited by 142 · see citing works
Tai, I. T., Dai, M., Owen, D. A., & Chen, L. B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23002 · Cited by 142 · see citing works
Droguett, R., Cabello‐Verrugio, C., Riquelme, C. A., & Brandan, E. (2006) · Matrix Biology · doi:10.1016/j.matbio.2006.04.004 · Cited by 140 · see citing works
Lenk, K., Erbs, S., Höllriegel, R., Beck, E. B., Linke, A. H.-P., Gielen, S., Winkler, S. M., Sandri, M., Hambrecht, R., Schuler, G. C., et al. (2011) · European Journal of Preventive Cardiology · doi:10.1177/1741826711402735 · Cited by 140 · see citing works
Lenk, K., Schur, R., Linke, A., Erbs, S., Matsumoto, Y., Adams, V., & Schuler, G. C. (2009) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfp020 · Cited by 136 · see citing works
Mok, S. C., Chan, W. Y., Wong, K., Muto, M. G., & Berkowitz, R. S. (1996) · PubMed · Cited by 136 · see citing works
Senescent fibroblasts drive ageing pigmentation: A potential therapeutic target for senile lentigo
Yoon, J. E., Kim, Y., Kwon, S., Kim, M., Kim, Y. H., Kim, J., Park, T. J., & Kang, H. Y. (2018) · Theranostics · doi:10.7150/thno.26975 · Cited by 134 · see citing works
Exercise induces expression of leukaemia inhibitory factor in human skeletal muscle
Broholm, C., Mortensen, O. H., Nielsen, S., Akerstrom, T., Zankari, A., Dahl, B., & Pedersen, B. K. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.149781 · Cited by 132 · see citing works
Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise
Brenmoehl, J., Albrecht, E., Komolka, K., Schering, L., Langhammer, M., Hoeflich, A., & Maak, S. (2014) · International Journal of Biological Sciences · doi:10.7150/ijbs.7972 · Cited by 127 · see citing works
Eaton, M., Granata, C., Barry, J., Safdar, A., Bishop, D., & Little, J. P. (2018) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2017.01.003 · Cited by 126 · see citing works
Quan, N., Sun, W., Wang, L., Xu, C., Bogan, J. S., Zhou, X., Cates, C. A., Liu, Q., Zheng, Y., & Li, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700063r · Cited by 124 · see citing works
Achen, M. G., & Stacker, S. A. (1998) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1998.700404.x · Cited by 121 · see citing works
Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism
Tanianskii, D. A., Jarzebska, N., Birkenfeld, A. L., O’Sullivan, J. F., & Rodionov, R. N. (2019) · Nutrients · doi:10.3390/nu11030524 · Cited by 121 · see citing works
Briken, S., Rosenkranz, S. C., Keminer, O., Patra, S., Ketels, G., Heesen, C., Hellweg, R., Pleß, O., Schulz, K., & Gold, S. M. (2016) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2016.08.007 · Cited by 118 · see citing works
Novelle, M. G., Contreras, C., Romero, A., López, M., & Diéguez, C. (2013) · International Journal of Endocrinology · doi:10.1155/2013/746281 · Cited by 117 · see citing works
Liu, X., Niu, Y., Yuan, H., Huang, J. Y., & Fu, L. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.015 · Cited by 116 · see citing works
Sestrins are evolutionarily conserved mediators of exercise benefits
Kim, M., Sujkowski, A. L., Namkoong, S., Gu, B., Cobb, T., Kim, B. Y., Kowalsky, A. H., Cho, C., Semple, I. A., Ro, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13442-5 · Cited by 116 · see citing works
Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.008 · Cited by 113 · see citing works
Effects of aging and sex on plasma insulin-like growth factor I (IGF-I) levels in normal adults
Yamamoto, H., Sohmiya, M., Oka, N., & Kato, Y. (1991) · European Journal of Endocrinology · doi:10.1530/acta.0.1240497 · Cited by 108 · see citing works
Shi, C.-X., Zhao, M.-X., Shu, X.-D., Xiong, X.-Q., Wang, J.-J., Gao, X.-Y., Chen, Q., Li, Y.-H., Kang, Y.-M., & Zhu, G.-Q. (2016) · Scientific Reports · doi:10.1038/srep21924 · Cited by 108 · see citing works
Whitham, M., Chan, M. H. S., Pal, M., Matthews, V. B., Prelovsek, O., Lunke, S., El-Osta, A., Broenneke, H., Alber, J., Brüning, J. C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.310581 · Cited by 107 · see citing works
Role of physical exercise in Alzheimer's disease
Chen, W., Zhang, X., & Huang, W. (2016) · Biomedical Reports · doi:10.3892/br.2016.607 · Cited by 106 · see citing works
Staiger, H., Böhm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F. E., Fritsche, A., Stefan, N., Weigert, C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061903 · Cited by 105 · see citing works
Endurance training enhances skeletal muscle interleukin-15 in human male subjects
Rinnov, A., Yfanti, C., Nielsen, S., Åkerström, T. C. A., Peijs, L., Zankari, A., Fischer, C. P., & Pedersen, B. K. (2014) · Endocrine · doi:10.1007/s12020-013-9969-z · Cited by 103 · cited 1× · see citing works
“In rats with type 2 diabetes, the expression of IL-15 protein increased significantly in the soleus after 12 weeks of aerobic exercise (treadmill training) [128] and increased by 40% in the vastus lateralis of 30 men after 12 weeks of endurance exercise on a cycloergometer [129].”
BackgroundBrzóska, E., Kowalewska, M., Markowska‐Zagrajek, A., et al. (2012) · Biology of the Cell · doi:10.1111/boc.201200022 · Cited by 102 · see citing works
Age-dependent alterations of decorin glycosaminoglycans in human skin
Li, Y., Liu, Y., Xia, W., Lei, D., Voorhees, J. J., & Fisher, G. J. (2013) · Scientific Reports · doi:10.1038/srep02422 · Cited by 101 · see citing works
Increased expression of VEGF following exercise training in patients with heart failure
Gustafsson, T. P., Bodin, K., Sylvén, C., Gordon, A., Tyni‐Lenné, R., & Jansson, E. (2001) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2001.00816.x · Cited by 99 · see citing works
Myostatin expression in age and denervation-induced skeletal muscle atrophy.
Baumann, A. P., Ibebunjo, C., GRASSER, W. A., & Paralkar, V. M. (2003) · PubMed · Cited by 99 · see citing works
Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines
Pourteymour, S., Eckardt, K., Holen, T., Langleite, T. M., Lee-Ødegård, S., Jensen, J., Birkeland, K. I., Drevon, C. A., & Hjorth, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.007 · Cited by 99 · see citing works
The Insulin/IGF System in Mammalian Sexual Development and Reproduction
Neirijnck, Y., Papaioannou, M. D., & Nef, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184440 · Cited by 99 · see citing works
Elevated Plasma Levels of Interleukin‐6 in Postmenopausal Women Do Not Correlate with Bone Density
Kania, D. M., Binkley, N., Checovich, M. M., Havighurst, T. C., Schilling, M. L., & Ershler, W. B. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07328.x · Cited by 97 · see citing works
Zhang, J., Ren, C. X., Qi, Y., Lou, L. X., Chen, L., Zhang, L. K., Wang, X., & Tang, C. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.03.040 · Cited by 97 · see citing works
Boone‐Heinonen, J., Evenson, K. R., Taber, D. R., & Gordon‐Larsen, P. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2008.00533.x · Cited by 96 · see citing works
Heinemeier, K. M., Bjerrum, S., Schjerling, P., & Kjær, M. (2011) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.2011.01414.x · Cited by 94 · see citing works
The Muscle Metabolome Differs between Healthy and Frail Older Adults
Fazelzadeh, P., Hangelbroek, R., Tieland, M., de Groot, C. P. G. M., Verdijk, L. B., van Loon, L. J. C., Smilde, A. K., Alves, R. D. A. M., Vervoort, J. J. M., Müller, M. M., et al. (2016) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00840 · Cited by 94 · see citing works
Peng, L., Lee, W., Liu, L., Lin, M., & Chen, L. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12302 · Cited by 93 · see citing works
de Sire, R., Rizzatti, G., Ingravalle, F., Pizzoferrato, M., Petito, V., Lopetuso, L. R., Graziani, C., Alessandro de, S. I. R. E., Mentella, M. C., Mele, M. C., et al. (2018) · Minerva Gastroenterologica e Dietologica · doi:10.23736/s1121-421x.18.02511-4 · Cited by 93 · see citing works
The p38–PGC-1α–irisin–betatrophin axis
Sanchis‐Gomar, F., & Pérez-Quilis, C. (2013) · Adipocyte · doi:10.4161/adip.27370 · Cited by 92 · see citing works
Effects of Exercise on Mild-to-Moderate Depressive Symptoms in the Postpartum Period
McCurdy, A., Boulé, N. G., Sivak, A., & Davenport, M. H. (2017) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002053 · Cited by 91 · see citing works
The injury response of aged tendons in the absence of biglycan and decorin
Dunkman, A. A., Buckley, M. R., Mienaltowski, M. J., et al. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.10.008 · Cited by 90 · see citing works
Rai, R., Ghosh, A. K., Eren, M., Mackie, A. R., Levine, D. C., Kim, S., Cedernaes, J., Ramirez, V., Procissi, D., Smith, L. H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.057 · Cited by 90 · see citing works
IL-6 release from muscles during exercise is stimulated by lactate-dependent protease activity
Højman, P., Brolin, C., Nørgaard-Christensen, N., Dethlefsen, C., Lauenborg, B. T., Olsen, C. K., Åbom, M. M., Krag, T. O. B., Gehl, J., & Pedersen, B. K. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00414.2018 · Cited by 89 · see citing works
Chew, J., Tay, L., Lim, J. P., Leung, B. P., Yeo, A., Yew, S., Ding, Y. Y., & Lim, W. S. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-019-1255-1 · Cited by 88 · see citing works
Rocha‐Rodrigues, S., Rodrı́guez, A., Gouveia, A., Gonçalves, I. O., Becerril, S., Ramírez, B., Beleza, J., Frühbeck, G., Ascensão, A. A. M. R., & Magalhães, J. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.09.023 · Cited by 86 · see citing works
Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis
Wang, Z., Bian, L., Mo, C., Shen, H., Zhao, L., Su, K., Kukula, M., Lee, J. T., Armstrong, D. W., Recker, R. R., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-0766-y · Cited by 85 · see citing works
Interleukin 4 is at 5q31 and interleukin 6 is at 7p15
Sutherland, G., Baker, E., Callen, D. F., Hyland, V. J., Wong, G. G., Clark, S., Jones, S., Eglinton, L., Shannon, M. F., Lopez, A. F., et al. (1988) · Human Genetics · doi:10.1007/bf00282171 · Cited by 83 · see citing works
Structure of human osteonectin based upon analysis of cDNA and genomic sequences
Villarreal, X. C., Mann, K. G., & Long, G. L. (1989) · Biochemistry · doi:10.1021/bi00441a049 · Cited by 83 · see citing works
Role of Apelin/APJ axis in cancer development and progression
Masoumi, J., Jafarzadeh, A., Khorramdelazad, H., Abbasloui, M., Abdolalizadeh, J., & Jamali, N. (2020) · Advances in Medical Sciences · doi:10.1016/j.advms.2020.02.002 · Cited by 83 · see citing works
Hangelbroek, R., Fazelzadeh, P., Tieland, M., Boekschoten, M. V., Hooiveld, G. J. E. J., van Duynhoven, J., Timmons, J. A., Verdijk, L. B., de Groot, C. P. G. M., van Loon, L. J. C., et al. (2016) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12099 · Cited by 82 · see citing works
Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.
Buckbinder, L., Talbott, R. L., Seizinger, B. R., & Kley, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10640 · Cited by 81 · see citing works
Age-related changes in cartilage endogenous osteogenic protein-1 (OP-1)
Chubinskaya, S., Kumar, B., Merrihew, C., Heretis, K., Rueger, D. C., & Kuettner, K. E. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(02)00158-8 · Cited by 79 · see citing works
Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review
Vital, T. M., Stein, A. M., Coelho, F. G. D. M., Arantes, F. J., Teodorov, E., & Galduróz, J. C. F. (2014) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2014.04.011 · Cited by 79 · see citing works
Lenhare, L., Crisol, B. M., Silva, V. R. R., Katashima, C. K., Cordeiro, A. V., Pereira, K. D., Luchessi, A. D., da Silva, A. S. R., Cintra, D. E., Moura, L. P., et al. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.009 · Cited by 79 · see citing works
Metabolomic Analysis of the Skeletal Muscle of Mice Overexpressing PGC-1α
Hatazawa, Y., Senoo, N., Tadaishi, M., Ogawa, Y., Ezaki, O., Kamei, Y., & Miura, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129084 · Cited by 78 · see citing works
Plasma irisin levels predict telomere length in healthy adults
Rana, K. S., Arif, M., Hill, E. J., Aldred, S., Nagel, D. A., Nevill, A. M., Randeva, H. S., Bailey, C. J., Bellary, S., & Brown, J. E. P. (2014) · AGE · doi:10.1007/s11357-014-9620-9 · Cited by 77 · see citing works
Parachikova, A. I., & Cotman, C. W. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.001 · Cited by 77 · see citing works
Matsakas, A., Friedel, A., Hertrampf, T., & Diel, P. R. (2005) · Acta Physiologica Scandinavica · doi:10.1111/j.1365-201x.2005.01406.x · Cited by 77 · see citing works
Yeh, L. C., Tsai, A. D., & Lee, J. C. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10315 · Cited by 76 · see citing works
Welle, S. L., Bhatt, K. S., Shah, B., & Thornton, C. A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00025-6 · Cited by 76 · see citing works
Ruan, Q., Huang, Y., Yang, L., Ruan, J., Gu, W., Zhang, X., Zhang, Y., Zhang, W., & Yu, Z. (2019) · Peptides · doi:10.1016/j.peptides.2019.01.004 · Cited by 76 · see citing works
Sestrins at the Interface of ROS Control and Autophagy Regulation in Health and Disease
Cordani, M., Sánchez‐Álvarez, M., Strippoli, R., Bazhin, A. V., & Donadelli, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1283075 · Cited by 75 · see citing works
The human gene encoding insulin-like growth factor I is located on chromosome 12
Höppener, J. W. M., Holthuizen, P. E., van Kessel, A. H. M. G., Jansen, M., Kittur, S., Antonarakis, S. E., Lips, C. J. M., & Sussenbach, J. S. (1985) · Human Genetics · doi:10.1007/bf00293288 · Cited by 74 · see citing works
Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration
Nishiguchi, M. A., Spencer, C. A., Leung, D. H. Y., & Leung, T. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.08.054 · Cited by 74 · see citing works
Ryan, A. S., Li, G., Blumenthal, J. B., & Ortmeyer, H. K. (2013) · Obesity · doi:10.1002/oby.20216 · Cited by 73 · see citing works
Quinn, L. S., & Anderson, B. G. (2011) · Journal of Obesity · doi:10.1155/2011/456347 · Cited by 73 · see citing works
Inhibition of Myostatin Signaling through Notch Activation following Acute Resistance Exercise
MacKenzie, M. G., Hamilton, D. L., Pepin, M. E., Patton, A., & Baar, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068743 · Cited by 72 · see citing works
Emmons, R. S., Niemiro, G. M., Owolabi, O., & Lisio, M. D. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00925.2015 · Cited by 71 · see citing works
Zhou, Y., Hellberg, M., Hellmark, T., Höglund, P., & Clyne, N. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz210 · Cited by 71 · see citing works
Skeletal muscle IL ‐15/ IL ‐15Rα and myofibrillar protein synthesis after resistance exercise
Pérez‐López, A., McKendry, J., Martín-Rincón, M., Morales‐Álamo, D., Kohler, B., Valadés, D., Buján, J., Calbet, J. A. L., & Breen, L. (2017) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12901 · Cited by 70 · see citing works
Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling
Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69 · see citing works
Quinn, L. S., Anderson, B. G., Strait‐Bodey, L., & Wolden‐Hanson, T. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.10.012 · Cited by 68 · see citing works
Reductions in serum IGF ‐1 during aging impair health span
Gong, Z., Kennedy, O. D., Sun, H., Wu, Y., Williams, G. A., Klein, L., Cardoso, L., Matheny, R. W., Hubbard, G. B., Ikeno, Y., et al. (2013) · Aging Cell · doi:10.1111/acel.12188 · Cited by 68 · see citing works
Short, K. R., Chadwick, J. Q., Teague, A. M., Tullier, M. A., WOLBERT, L. D., COLEMAN, C. L., & Copeland, K. C. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02698 · Cited by 68 · see citing works
Modulators of CXCR4 and CXCR7/ACKR3 Function
Adlere, I., Caspar, B., Arimont, M., Dekkers, S., Visser, K., Stuijt, J., de Graaf, C., Stocks, M. J., Kellam, B., Briddon, S. J., et al. (2019) · Molecular Pharmacology · doi:10.1124/mol.119.117663 · Cited by 68 · see citing works
Loeser, R., Im, H.-J., Richardson, B., Lu, Q., & Chubinskaya, S. (2008) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2008.08.003 · Cited by 67 · see citing works
Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent
Maalouf, G.-E., & Khoury, D. E. (2019) · Journal of Obesity · doi:10.1155/2019/6561726 · Cited by 67 · see citing works
Acute aerobic exercise leads to increased plasma levels of R- and S-β-aminoisobutyric acid in humans
Stautemas, J., Van Kuilenburg, A. B. P., Stroomer, L., Vaz, F., Blancquaert, L., Lefevere, F. B. D., Everaert, I., & Derave, W. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01240 · Cited by 66 · see citing works
Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury
Bi, J.-B., Yang, L.-F., Wang, T., Zhang, J., Li, T., Ren, Y., Wang, M.-Z., Chen, X., Lv, Y., & Wu, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/6946037 · Cited by 66 · see citing works
Rich, B., Scadeng, M., Yamaguchi, M., Wagner, P. D., & Breen, E. C. (2017) · The Journal of Physiology · doi:10.1113/jp273994 · Cited by 65 · see citing works
Sestrins at the crossroad between stress and aging
Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 64 · see citing works
The relationship between plasma interleukin-15 levels and sarcopenia in outpatient older people
Yalçın, A., Sılay, K., Balik, A. R., Avcıoğlu, G., & Şenat, A. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0848-y · Cited by 64 · see citing works
The Insulin-Like Growth Factor Axis and Plasma Lipid Levels in the Elderly1
Ceda, G. P., Dall’Aglio, E., Magnacavallo, A., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4548 · Cited by 63 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions
de Oliveira dos Santos, A. R., de Oliveira Zanuso, B., Miola, V. F. B., Barbalho, S. M., Santos Bueno, P. C., Flato, U. A. P., Detregiachi, C. R. P., Buchaim, D. V., Buchaim, R. L., Tofano, R. J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052639 · Cited by 189 · see citing works
Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors
Alizadeh Pahlavani, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.811751 · Cited by 145 · see citing works
The role of exercise-induced myokines in promoting angiogenesis
Qi, C., Song, X., Wang, H., Yan, Y., & Liu, B. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.981577 · Cited by 63 · see citing works
- Authors
- Kwon, J. H., Moon, K. M., & Min, K.-W.
- Affiliations
- Indiana University Bloomington (US)
- University of Ulsan (KR)
- Hanyang University Guri Hospital (KR)
- Corresponding author
- Moon, Kyoung Min
- Venue
- Healthcare
- Publisher
- MDPI AG
- Published
- 2020-10-01
- Volume
- 8
- Issue
- 4
- Pages
- 378
- ISSN
- 2227-9032 (ISSN-L)
- PMC
- PMC7712334
- OpenAlex
- W3090587459
- Cited by
- 116
- References
- 280
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 19 · 2023: 20 · 2022: 24 · 2021: 15
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Healthcare (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- myokines, physical activity, aging, older adults, skeletal muscle health, aerobic exercise, anaerobic exercise, apelin, BMP-7, decorin, insulin-like growth factor I, IL-15, interleukin-6, irisin, CXCL12, sestrins, SPARC, VEGF-A, myostatin, metabolic disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review