The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review
Abstract
Background/Objective: Beta-alanine supplementation increases muscle carnosine content and also improves exercise capacity and performance in young adults, with mixed findings emerging from the few studies investigating its effects on older participants. Therefore, this study aimed to systematically review the evidence regarding the effects of beta-alanine on exercise capacity, muscle strength, and functional performance of older adults. Methods: This systematic review was conducted following the specific methodological guidelines of the Preferred Report Items for Systematic Reviews and Meta-Analyses and the Physiotherapy Evidence Database scale. Furthermore, the Cochrane risk-of-bias assessment tool was used. The search was carried out in five relevant databases (MEDLINE, Embase, Web of Science, Scopus, and Cochrane Library) from inception up to March 2024. Results: Of the 1,749 registers identified, only five met the established criteria and were included in this systematic review. A total of 163 older adults (mean age ± SD: 69.1 ± 2.8 years; range: 66.2–72.7 years) were included across all five studies. The majority of studies included participants from both genders. The mean intervention duration ± SD was 11.7 ± 1.0 weeks. The mean daily dosage was 2.7 ± 0.4 g/day (range: 2.4–3.2 g/day). Conclusion: Overall, exercise capacity may be improved following supplementation protocols with dosages ranging from 2.4 to 3.2 g/day. Muscle strength and functional performance do not seem to be improved by beta-alanine since these tasks are not significantly impacted by acidosis buildup.
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Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
RoB 2: a revised tool for assessing risk of bias in randomised trials
Sterne, J. A. C., Savović, J., Page, M. J., Elbers, R. G., Blencowe, N. S., Boutron, I., Cates, C. J., Cheng, H.-Y., Corbett, M. S., Eldridge, S. M., et al. (2019) · BMJ · doi:10.1136/bmj.l4898 · Cited by 34,787
Verhagen, A. P., de Vet, H. C. W., de Bie, R. A., Kessels, A. G. H., Boers, M., Bouter, L. M., & Knipschild, P. G. (1998) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00131-0 · Cited by 2,379
Grip Strength: An Indispensable Biomarker For Older Adults
Bohannon, R. W. (2019) · Clinical Interventions in Aging · doi:10.2147/cia.s194543 · Cited by 994
Association of Muscle Power With Functional Status in Community-Dwelling Elderly Women
Foldvari, M., Clark, M., Laviolette, L. C., Bernstein, M. A., Kaliton, D., Castaneda, C., Pu, C. T., Hausdorff, J. M., Fielding, R. A., & Singh, M. A. F. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.4.m192 · Cited by 653
Muscle strength: clinical and prognostic value of hand-grip dynamometry
Bohannon, R. W. (2015) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000202 · Cited by 539
Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Fallowfield, J. L., Hill, C. A., Sale, C., & Wise, J. A. (2006) · Amino Acids · doi:10.1007/s00726-006-0299-9 · Cited by 534
Hill, C. A., Harris, R. C., Kim, H. J., Harris, B. D., Sale, C., Boobis, L. H., Kim, C. K., & Wise, J. A. (2007) · Amino Acids · doi:10.1007/s00726-006-0364-4 · Cited by 445
Derave, W., Özdemir, M. S., Harris, R. C., Pottier, A., Reyngoudt, H., Koppo, K., Wise, J. A., & Achten, E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00397.2007 · Cited by 324
Mechanisms of Itch Evoked by β-Alanine
Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H., & Dong, X. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3509-12.2012 · Cited by 324
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Molina, D. C. (2026) · Rovira & Virgili repository
Sierra, R. H. (2026) · Rovira & Virgili repository
ASSOCIAÇÃO ENTRE FORÇA MUSCULAR E DESEMPENHO FÍSICO EM IDOSOS: UMA REVISÃO SISTEMÁTICA
da Silva, A. M. C., Santiago, J. D. M., & de Fontes, P. A. D. S. (2026) · Derecho y cambio social. · doi:10.54899/dcs.v23i97.7412
Metadata
- Authors
- de Camargo, J. B. B., & Brigatto, F. A.
- Affiliations
- Universidade Federal de São Carlos (BR)
- Methodist University of Piracicaba (BR)
- Venue
- Journal of Aging and Physical Activity
- Publisher
- Human Kinetics
- Published
- 2025-08-01
- Volume
- 33
- Issue
- 4
- Pages
- 399-407
- ISSN
- 1063-8652 (ISSN-L)
- 1543-267X
- OpenAlex
- W4405813072
- Semantic Scholar
- d79ac8400b43e6c1bc0ab1807a5a1b72b5824861
- Cited by
- 3
- References
- 42
- Citations by year
- 2026: 3
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Aging and Physical Activity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Biochemical effects in animals
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- beta-alanine, dietary supplementation, older adults, exercise capacity, muscle strength, functional performance, muscle carnosine, acidosis, aging
- MeSH terms
- Physical Functional Performance, Aged, Female, Humans, Male, beta-Alanine, Exercise Tolerance, Dietary Supplements, Muscle Strength
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- CoChat. (2026). Citation check: Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review. https://app.cochat.ai/papers/10.1123/japa.2024-0118
- The paper
- de Camargo, J. B. B., & Brigatto, F. A. (2025). Beta-Alanine for Improving Exercise Capacity, Muscle Strength, and Functional Performance of Older Adults: A Systematic Review. Journal of Aging and Physical Activity. https://doi.org/10.1123/japa.2024-0118
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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