Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity

Hill, C. A.; Harris, R. C.; Kim, H. J.; Harris, B. D.; Sale, C.; Boobis, L. H.; Kim, C. K.; Wise, J. A.

doi:10.1007/s00726-006-0364-4

Cited by 445Biochemical effects in animalsMuscle metabolism and nutritionSports Performance and Training

Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity

Hill, C. A., Harris, R. C., Kim, H. J., Harris, B. D., Sale, C., Boobis, L. H., Kim, C. K., Wise, J. A.·2007·Amino Acids

DOI 10.1007/s00726-006-0364-4

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Abstract

Muscle carnosine synthesis is limited by the availability of beta-alanine. Thirteen male subjects were supplemented with beta-alanine (CarnoSyn) for 4 wks, 8 of these for 10 wks. A biopsy of the vastus lateralis was obtained from 6 of the 8 at 0, 4 and 10 wks. Subjects undertook a cycle capacity test to determine total work done (TWD) at 110% (CCT(110%)) of their maximum power (Wmax). Twelve matched subjects received a placebo. Eleven of these completed the CCT(110%) at 0 and 4 wks, and 8, 10 wks. Muscle biopsies were obtained from 5 of the 8 and one additional subject. Muscle carnosine was significantly increased by +58.8% and +80.1% after 4 and 10 wks beta-alanine supplementation. Carnosine, initially 1.71 times higher in type IIa fibres, increased equally in both type I and IIa fibres. No increase was seen in control subjects. Taurine was unchanged by 10 wks of supplementation. 4 wks beta-alanine supplementation resulted in a significant increase in TWD (+13.0%); with a further +3.2% increase at 10 wks. TWD was unchanged at 4 and 10 wks in the control subjects. The increase in TWD with supplementation followed the increase in muscle carnosine.

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10-wk of β-alanine supplementation increased muscle carnosine content and resulted in an improvement in a cycling capacity test at 110% Wmax.
“Hill et al. [211] extended on these findings by showing 10-wk of β-alanine supplementation increased muscle carnosine content and resulted in an improvement in a cycling capacity test at 110% Wmax.”
From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [211]

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Authors: Hill, C. A., Harris, R. C., Kim, H. J., Harris, B. D., Sale, C., Boobis, L. H., Kim, C. K., & Wise, J. A.
Affiliations: University of Chichester (GB)
Korea National Sport University (KR)
Qinetiq (United Kingdom) (GB)
Sunderland Royal Hospital (GB)
ORCID: Sale, C.
Wise, J. A.
Venue: Amino Acids
Publisher: Springer Science and Business Media LLC
Published: 2006-07-28
Volume: 32
Issue: 2
Pages: 225-233
ISSN: 0939-4451 (ISSN-L)
1438-2199
DOI: 10.1007/s00726-006-0364-4
OpenAlex: W2041824571
Cited by: 445
References: 49
Citations by year: 2026: 13 · 2025: 16 · 2024: 20 · 2023: 24 · 2022: 18 · 2021: 27 · 2020: 31 · 2019: 21 · 2018: 34 · 2017: 15 · 2016: 24 · 2015: 21 · 2014: 31 · 2013: 36 · 2012: 30
FWCI: 8.42
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Amino Acids (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Biochemical effects in animals
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords: beta-alanine supplementation, muscle carnosine, skeletal muscle, high-intensity cycling, taurine, vastus lateralis, muscle fiber type, exercise capacity, amino acid supplementation
MeSH terms: Adult, Biopsy, Carnosine, Drug Administration Schedule, Exercise Test, Humans, Hydrogen-Ion Concentration, Male, Models, Biological, Protons, Taurine, Time Factors, beta-Alanine, Muscle, Skeletal, Dietary Supplements

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Influence of β-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity

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