The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mechanisms of Itch Evoked by β-Alanine
Open accessAbstract
β-alanine, a popular supplement for muscle building, induces itch and tingling after consumption, but the underlying molecular and neural mechanisms are obscure. Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, a G-protein-coupled receptor expressed by a subpopulation of primary sensory neurons. These neurons exclusively innervate the skin, respond to β-alanine, heat, and mechanical noxious stimuli but do not respond to histamine. In humans, intradermally injected β-alanine induced itch but neither wheal nor flare, suggesting that the itch was not mediated by histamine. Thus, the primary sensory neurons responsive to β-alanine are likely part of a histamine-independent itch neural circuit and a target for treating clinical itch that is unrelieved by anti-histamines.
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Harris, R. C., Tallon, M. J., Dunnett, M., Boobis, L., Coakley, J., Kim, H. J., Fallowfield, J. L., Hill, C. A., Sale, C., & Wise, J. A. (2006) · Amino Acids · doi:10.1007/s00726-006-0299-9 · Cited by 534
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Azimi, E., Reddy, V. B., Shade, K.-T. C., Anthony, R. M., Talbot, S., Pereira, P. J. S., & Lerner, E. A. (2016) · JCI Insight · doi:10.1172/jci.insight.89362 · Cited by 178
Lancha Junior, A. H., de Salles Painelli, V., Saunders, B., & Artioli, G. G. (2015) · Sports Medicine · doi:10.1007/s40279-015-0397-5 · Cited by 167
Identification of a Spinal Circuit for Mechanical and Persistent Spontaneous Itch
Pan, H., Fatima, M., Li, A., Lee, H., Cai, W., Horwitz, L., Hor, C. C., Zaher, N., Cin, M., Slade, H., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.06.016 · Cited by 140
Spinal somatostatin-positive interneurons transmit chemical itch
Fatima, M., Ren, X., Pan, H., Slade, H. F. E., Asmar, A. J., Xiong, C. M., Shi, A., Xiong, A. E., Wang, L., & Duan, B. (2019) · Pain · doi:10.1097/j.pain.0000000000001499 · Cited by 41
Bell, A. M., Gutierrez-Mecinas, M., Stevenson, A., Casas-Benito, A., Wildner, H., West, S. J., Watanabe, M., & Todd, A. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-69711-7 · Cited by 25
Metadata
- Authors
- Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H., & Dong, X.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-10-17
- Volume
- 32
- Issue
- 42
- Pages
- 14532-14537
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1965018866
- Cited by
- 324
- References
- 1
- FWCI
- 10.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Sun, S., LaMotte, R. H., & Dong, X. (2012). Mechanisms of Itch Evoked by β-Alanine. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.3509-12.2012
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