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Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

Hilgendorf, Constanze, Ahlin, Gustav, Seithel, Annick, Artursson, Per, Ungell, Anna-Lena, Karlsson, Johan·2007·Drug Metabolism and Disposition

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Research works printed but not linked: 37

  1. Anderle, 2003, Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines, Pharmacol Res, 20, 3, 10.1023/A:1022282221530 · DOI
  2. Applied Biosystems (1997) Relative Quantification of Gene Expression User Bulletin #2: ABI PRISM 7700 Sequence Detection System
  3. Augustine, 2005, Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier, Drug Metab Dispos, 33, 182, 10.1124/dmd.104.001024 · DOI
  4. Bakos, 2007, Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1), Pflugers Arch, 453, 621, 10.1007/s00424-006-0160-8 · DOI · Paper page
  5. Behrens, 2004, Variation of peptide transporter (PepT1 and HPT1) expression in Caco-2 cells as a function of cell origin, J Pharm Sci, 93, 1743, 10.1002/jps.20062 · DOI
  6. Bleasby, 2006, Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition, Xenobiotica, 36, 963, 10.1080/00498250600861751 · DOI · Paper page
  7. Cui, 2001, Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2, Mol Pharmacol, 60, 934, 10.1016/S0026-895X(24)12502-3 · DOI · Paper page
  8. Cundy, 2004, XP13512 [({+/–})-1-([({alpha}-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug. II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys, J Pharmacol Exp Ther, 311, 324, 10.1124/jpet.104.067959 · DOI
  9. de Lange, 2004, Potential role of ABC transporters as a detoxification system at the blood-CSF barrier, Adv Drug Deliv Rev, 56, 1809
  10. Dietrich, 2003, ABC of oral bioavailability: transporters as gatekeepers in the gut, Gut, 52, 1788, 10.1136/gut.52.12.1788 · DOI · Paper page
  11. Ekaratanawong, 2004, Human organic anion transporter 4 is a renal apical organic anion/dicarboxylate exchanger in the proximal tubules, J Pharmacol Sci, 94, 297, 10.1254/jphs.94.297 · DOI · Paper page
  12. Englund, 2006, Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells, Eur J Pharm Sci, 29, 269, 10.1016/j.ejps.2006.04.010 · DOI · Paper page
  13. Halestrap, 2004, The SLC16 gene family—from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond, Pflugers Arch, 447, 619, 10.1007/s00424-003-1067-2 · DOI · Paper page
  14. Jedlitschky, 2006, Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition, Expert OpinDrug Metab Toxicol, 2, 351, 10.1517/17425255.2.3.351 · DOI · Paper page
  15. Jonker, 2004, Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3), J Pharmacol Exp Ther, 308, 2, 10.1124/jpet.103.053298 · DOI · Paper page
  16. Jung, 2001, Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha, J Biol Chem, 276, 37206, 10.1074/jbc.M103988200 · DOI · Paper page
  17. Koepsell, 2004, The SLC22 drug transporter family, Pflugers Arch, 447, 666, 10.1007/s00424-003-1089-9 · DOI · Paper page
  18. Landowski, 2003, Gene expression in the human intestine and correlation with oral valacyclovir pharmacokinetic parameters, J Pharmacol Exp Ther, 306, 778, 10.1124/jpet.103.051011 · DOI
  19. Liu, 2006, Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers, J Pharmacol Exp Ther, 318, 395, 10.1124/jpet.106.103390 · DOI
  20. Mikkaichi, 2004, The organic anion transporter (OATP) family, Drug Metab Pharmacokinet, 19, 171, 10.2133/dmpk.19.171 · DOI · Paper page
  21. Nagasawa, 2002, Monocarboxylate transporter mediates uptake of lovastatin acid in rat cultured mesangial cells, J Pharm Sci, 91, 2605, 10.1002/jps.10246 · DOI
  22. Ninomiya, 2005, Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2, Drug Metab Dispos, 33, 225, 10.1124/dmd.104.002196 · DOI
  23. Nishimura, 2005, Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamily, Drug Metab Pharmacokinet, 20, 452, 10.2133/dmpk.20.452 · DOI · Paper page
  24. Okamura, 2002, Transport and uptake of nateglinide in Caco-2 cells and its inhibitory effect on human monocarboxylate transporter MCT1, Br J Pharmacol, 137, 391, 10.1038/sj.bjp.0704875 · DOI
  25. Otsuka, 2005, A human transporter protein that mediates the final excretion step for toxic organic cations, Proc Natl Acad Sci U S A, 102, 17923, 10.1073/pnas.0506483102 · DOI · Paper page
  26. Pfaffl, 2004, Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper—Excel-based tool using pair-wise correlations, Biotechnol Lett, 26, 509, 10.1023/B:BILE.0000019559.84305.47 · DOI · Paper page
  27. Pfrunder, 2003, Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines, J Pharm Pharmacol, 55, 59, 10.1111/j.2042-7158.2003.tb02434.x · DOI
  28. Seithel, 2006, Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells, Eur J Pharm Sci, 28, 291, 10.1016/j.ejps.2006.03.003 · DOI · Paper page
  29. Sun, 2002, Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs, Pharmacol Res, 19, 1400, 10.1023/A:1020483911355 · DOI · Paper page
  30. Sun, 2004, Multidrug resistance P-glycoprotein: crucial significance in drug disposition and interaction, Med Sci Monit, 10, RA5
  31. Sun, 2001, Isolation of a family of organic anion transporters from human liver and kidney, Biochem Biophys Res Commun, 283, 417, 10.1006/bbrc.2001.4774 · DOI · Paper page
  32. Taipalensuu, 2004, Exploring the quantitative relationship between the level of MDR1 transcript, protein and function using digoxin as a marker of MDR1-dependent drug efflux activity, Eur J Pharm Sci, 21, 69, 10.1016/S0928-0987(03)00204-5 · DOI
  33. Taipalensuu, 2001, Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers, J Pharmacol Exp Ther, 299, 164, 10.1016/S0022-3565(24)29314-9 · DOI · Paper page
  34. Treiber, 2004, Inhibition of organic anion transporting polypeptide-mediated hepatic uptake is the major determinant in the pharmacokinetic interaction between bosentan and cyclosporin A in the rat, J Pharmacol Exp Ther, 308, 1121, 10.1124/jpet.103.061614 · DOI
  35. Vandesompele, 2002, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes, Genome Biol, 3, 1, 10.1186/gb-2002-3-7-research0034 · DOI · Paper page
  36. Zimmermann, 2005, Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract, Drug Metab Dispos, 33, 219, 10.1124/dmd.104.001354 · doi:10.1124/dmd.104.001354
  37. Zollner, 2005, Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter alpha/beta in the adaptive response to bile acids, Am J Physiol, G923

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Metadata

Authors
Hilgendorf, C., Ahlin, G., Seithel, A., Artursson, P., Ungell, A.-L., & Karlsson, J.
Venue
Drug Metabolism and Disposition
Publisher
Elsevier BV
Published
2007-08
Volume
35
Issue
8
Pages
1333-1340
ISSN
0090-9556 (ISSN-L)
OpenAlex
W1970359870
Cited by
583
References
4
FWCI
17.96
Type
journal article
Language
en
Open access
closed
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)

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CoChat. (2026). Citation check: Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines. https://app.cochat.ai/papers/10.1124/dmd.107.014902
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Hilgendorf, C., Ahlin, G., Seithel, A., Artursson, P., Ungell, A.-L., & Karlsson, J. (2007). Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines. Drug Metabolism and Disposition. https://doi.org/10.1124/dmd.107.014902

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