Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites

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Sulfamethoxazole is metabolized to the hydroxylamine in humans

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N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes

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Reactions of the nitroso and hydroxylamine metabolites of sulfamethoxazole with reduced glutathione. Implications for idiosyncratic toxicity

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Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism‐dependent haptenation and T‐cell proliferation <i>in vivo</i>

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Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes.

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Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity

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Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine

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Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes

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The effect of genetic polymorphisms in CYP2C9 on sulphamethoxazole N-hydroxylation

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Isolation, identification and determination of sulfamethoxazole and its known metabolites in human plasma and urine by high-performance liquid chromatography

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An in vitro investigation of predisposition to sulphonamide idiosyncratic toxicity in dogs

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In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: a Comparison with SKF-525A

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The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole

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Roles of endogenous ascorbate and glutathione in the cellular reduction and cytotoxicity of sulfamethoxazole-nitroso

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Characterization of hydroxyl radical formation by microsomal enzymes using a water-soluble trap, terephthalate

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HPLC and LC-MS studies of hydroxylation of phenylalanine as an assay for hydroxyl radicals generated from Udenfriend’s reagent

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ROLE OF HUMAN CYCLOOXYGENASE-2 IN THE BIOACTIVATION OF DAPSONE AND SULFAMETHOXAZOLE

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Biodegradation of sulfamethoxazole by a bacterial consortium of Achromobacter denitrificans PR1 and Leucobacter sp. GP

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A generic approach for expanding homolog-targeted residue screening of sulfonamides using a fast matrix separation and class-specific fragmentation-dependent acquisition with a hybrid quadrupole-linear ion trap mass spectrometer

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Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro

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N-Acetyltransferase (NAT) 1 and NAT2 Enzyme Activities Drive Interindividual Variability in Sulfamethoxazole N-Acetylation

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Impact of Consciousness Energy Healing Treatment on the Isotopic Abundance Ratio of Sulfamethoxazole Using LC-MS and GC-MS Spectrometry

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Influence of Consciousness Energy Healing Treatment on the Isotopic Abundance Ratio of Sulfamethoxazole Using LC-MS and GC-MS Spectrometry

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Short Communication Nonenzymatic Formation of a Novel Hydroxylated Sulfamethoxazole Derivative in Human Liver Microsomes:

Bioanalysis, I., & Metabolites, S. (2008)

Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine

Cribb, A. E., & Spielberg, S. P. (1990) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)08652-0 · Cited by 65 · see citing works

Sulfamethoxazole is metabolized to the hydroxylamine in humans

Cribb, A. E., & Spielberg, S. P. (1992) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1992.57 · Cited by 175 · see citing works

N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes

Cribb, A. E., Spielberg, S. P., & Griffin, G. P. (1995) · Drug Metabolism and Disposition · doi:10.1016/s0090-9556(25)06552-3 · Cited by 169 · see citing works

CHEMICAL SYNTHESIS AND IN VITRO TOXICITY OF A REACTIVE INTERMEDIATE OF SULFAMETHOXAZOLE

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