Requirement of Intact Adenosine A1 Receptors for the Diuretic and Natriuretic Action of the Methylxanthines Theophylline and Caffeine
Abstract
Although the diuretic and natriuretic effects of the methylxanthines caffeine and theophylline are well established, the mechanisms responsible for these effects are unclear and may be related to inhibition of phosphodiesterases and/or antagonism of adenosine receptors. With regard to the latter, pharmacological blockade of A1 receptors can induce diuresis and natriuresis by inhibition of proximal tubular reabsorption. To elucidate the role of the A1 receptor in renal actions of methylxanthines, experiments were performed in A1 receptor knockout (A1R-/-) and littermate wild-type (A1R+/+) mice. Urinary excretion was determined in awake mice in metabolic cages over 3 h in response to theophylline (as theophylline2/ethylenediamine, 45 mg/kg), caffeine (45 mg/kg), or vehicle (0.9 ml/30 g b.wt. of 0.85% NaCl) given by oral gavage. Theophylline and caffeine elicited a diuresis and natriuresis (in absolute terms and related to urinary creatinine excretion) in A1R+/+ but not in A1R-/- mice. In a second series, the renal effect of intravenous application of theophylline (30 mg/kg) was determined in clearance experiments under anesthesia. This study revealed that the blunted diuretic and natriuretic effect of theophylline in A1R-/- mice was not due to different responses in blood pressure or glomerular filtration rate. The data indicate that an intact A1 receptor is necessary for caffeine- and theophylline-induced inhibition of renal reabsorption causing diuresis and natriuresis. This is consistent with the assumption that A1 receptor blockade mediates these effects.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Cites
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
Catterall, W. A., Chandy, K. G., Clapham, D. E., Gutman, G. A., Hofmann, F., Harmar, A. J., Abernethy, D. R., & Spedding, M. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.4.5 · Cited by 7,126 · see citing works
International Union of Pharmacology. XXV. Nomenclature and Classification of Adenosine Receptors
Fredholm, B. B., IJzerman, A. P., Jacobson, K. A., Klotz, K.-N., & Linden, J. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01511-4 · Cited by 2,585 · see citing works
Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor
Ledent, C. A., Vaugeois, J., Schiffmann, S. N., Pedrazzini, T., Yacoubi, M. E., Vanderhaeghen, J. J., Costentin, J., Heath, J. K., Vassart, G., & Parmentier, M. (1997) · Nature · doi:10.1038/41771 · Cited by 918 · see citing works
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501 · cited 1× · see citing works
“Both effects could be blocked with theophylline (Robertson et al., 1981; Fredholm, 1984).”
BackgroundSun, D., Samuelson, L. C., Yang, T., Huang, Y. G., Paliege, A., Saunders, T. L., Briggs, J., & Schnermann, J. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171317998 · Cited by 402 · see citing works
Self-citationRenal lithium excretion in man
Thomsen, K., & Schou, M. (1968) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1968.215.4.823 · Cited by 264 · see citing works
Caffeine and theophylline as adenosine receptor antagonists in humans.
Biaggioni, I., Paul, S., Puckett, A. E., & Arzubiaga, C. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20409-8 · Cited by 213 · see citing works
Adenosine formed by 5′-nucleotidase mediates tubuloglomerular feedback
Thomson, S. C., Bao, D., Deng, A., & Vallon, V. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8761 · Cited by 179 · see citing works
Self-citationVestal, R. E., Eiriksson, C. E., Musser, B., Ozaki, L., & Halter, J. B. (1983) · Circulation · doi:10.1161/01.cir.67.1.162 · Cited by 151 · see citing works
Renal effects of adenosine and their inhibition by theophylline in dogs
O�wald, H. (1975) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00501815 · Cited by 147 · see citing works
Adenosine as a possible mediator of metabolic control of glomerular filtration rate
Oßwald, H., Nabakowski, G., & Hermes, H. (1980) · International Journal of Biochemistry · doi:10.1016/0020-711x(80)90082-8 · Cited by 140 · see citing works
Natriuretic and Diuretic Actions of a Highly Selective Adenosine A1 Receptor Antagonist
Wilcox, C. S., Welch, W. J., Schreiner, G. F., & Belardinelli, L. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v104714 · Cited by 131 · see citing works
Role of renal medullary adenosine in the control of blood flow and sodium excretion
Zou, A.-P., Nithipatikom, K., Li, P., & Cowley, A. W. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.3.r790 · Cited by 98 · see citing works
Fredholm, B. B., Hedqvist, P., & Vernet, L. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90199-5 · Cited by 89 · see citing works
Renal action of adenosine: Effect on renin secretion in the rat
Oßwald, H., Schmitz, H. J., & Kemper, R. (1978) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00496190 · Cited by 87 · see citing works
Davis, J. O., & Shock, N. W. (1949) · Journal of Clinical Investigation · doi:10.1172/jci102211 · Cited by 73 · see citing works
Vallon, V., Richter, K., Huang, D. Y., Rieg, T., & Schnermann, J. B. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-004-1239-8 · Cited by 69 · see citing works
Self-citationTakeda, M., Yoshitomi, K., & Imai, M. (1993) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1993.265.4.f511 · Cited by 69 · see citing works
Brater, D. C., Kaojarern, S., & Chennavasin, P. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22076-6 · Cited by 67 · see citing works
Knight, R. J., Bowmer, C. J., & Yates, M. S. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13564.x · Cited by 66 · see citing works
A potential role for endogenous adenosine in control of human glomerular and tubular function
Balakrishnan, V. S., Coles, G. A., & Williams, J. D. (1993) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1993.265.4.f504 · Cited by 58 · see citing works
Munger, K. A., & Jackson, E. K. (1994) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1994.267.5.f783 · Cited by 53 · see citing works
Cardiovascular Pharmacology of the A2A Adenosine Receptor Antagonist, SCH 58261, in the Rat
Monopoli, A., Casati, C., Lozza, G., Forlani, A., & Ongini, E. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37372-0 · Cited by 52 · see citing works
Natriuretic and hypotensive effect of adenosine-1 blockade in essential hypertension.
van Buren, M., Bijlsma, J. A., de Boer, P., van Rijn, H. J. M., & Koomans, H. A. (1993) · Hypertension · doi:10.1161/01.hyp.22.5.728 · Cited by 48 · see citing works
Sole, F. D., Cerull, R., Babich, V., Quiñones, H., Gisler, S. M., Biber, J., Murer, H., Burckhardt, G., Helmle‐Kolb, C., & Moe, O. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306838200 · Cited by 46 · see citing works
Cardiovascular and renal actions of methylxanthines.
Bb, F. (1984) · PubMed · Cited by 44 · see citing works
Sole, F. D., Cerull, R., Petzke, S., Casavola, V., Burckhardt, G., & Helmle‐Kolb, C. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000072743.97583.db · Cited by 42 · see citing works
CVT-124, a Novel Adenosine A1 Receptor Antagonist with Unique Diuretic Activity
Gellai, M., Schreiner, G. F., Ruffolo, R. R., Fletcher, T., DeWolf, R., & Brooks, D. P. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37711-0 · Cited by 39 · see citing works
Adenosine stimulates phosphate and glucose transport in opossum kidney epithelial cells
Coulson, R., Johnson, R. A., Olsson, R. A., Cooper, D. R., & Scheinman, S. J. (1991) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1991.260.6.f921 · Cited by 39 · see citing works
Evidence for a role of protein kinase C-α in urine concentration
Yao, L., Huang, D., Pfaff, I. L., Nie, X., Leitges, M., & Vallon, V. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00274.2003 · Cited by 38 · see citing works
Self-citationKost, C. K., Herzer, W. A., Rominski, B. R., Mi, Z., & Jackson, E. K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35348-0 · Cited by 38 · see citing works
Effects of intravenous adenosine on renal function in healthy human subjects
Balakrishnan, V. S., Coles, G. A., & Williams, J. D. (1996) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1996.271.2.f374 · Cited by 37 · see citing works
Cai, H. N., Batuman, V., Puschett, D. B., & Puschett, J. B. (1994) · Life Sciences · doi:10.1016/0024-3205(94)00567-2 · Cited by 34 · see citing works
Kidney function in mice: thiobutabarbital versus ?-chloralose anesthesia
Rieg, T., Richter, K., Oßwald, H., & Vallon, V. (2004) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-004-0982-x · Cited by 27 · see citing works
Self-citationCai, H. N., Puschett, D. B., Guan, S., Batuman, V., & Puschett, J. B. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90451-4 · Cited by 21 · see citing works
Xanthine effects on renal proximal tubular function and cyclic AMP metabolism.
Coulson, R., & Scheinman, S. J. (1989) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23742-9 · Cited by 21 · see citing works
The Isolated Kidney and Its Response to Diuretic Agents
Kupfer, S., Thompson, D. D., & Pitts, R. F. (1951) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1951.167.3.703 · Cited by 20 · see citing works
Colin, A., Kraiem, Z., Kahana, L., & Hochberg, Z. (1984) · PubMed · Cited by 17 · see citing works
Effects of various diuretic agents in the mouse
Sim, M. F., & Hopcroft, R. (1976) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1976.tb02810.x · Cited by 14 · see citing works
Beutler, J. J., Koomans, H. A., Bijlsma, J. A., & Mees, E. J. D. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23020-8 · Cited by 11 · see citing works
ADENOSINE AS A POSSIBLE MEDIATOR OF METABOLIC CONTROL OF GLOMERULAR FILTRATION RATE
Oßwald, H., Nabakowski, G., & HERMES, H. (1980) · Elsevier eBooks · doi:10.1016/b978-0-08-025517-0.50058-8 · Cited by 10 · see citing works
AN INVESTIGATION OF THE SEX DIFFERENCE IN THE DIURETIC RESPONSE TO ETHACRYNIC ACID IN MICE
Cooling, M. J., & Sim, M. F. (1977) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1977.tb07536.x · Cited by 5 · see citing works
Fülgraff, G., GREVEN, J., & Meiforth, A. (1969) · PubMed · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Scientific Opinion on the safety of caffeine
EFSA Panel on Dietetic Products, N. A. A. (. (2015) · EFSA Journal · doi:10.2903/j.efsa.2015.4102 · Cited by 613 · see citing works
“The diuretic activity of caffeine can be explained by an interaction with the adenosine receptor A1 in the kidney, leading to inhibition of renal re-absorption and causing diuresis and natriuresis (Rieg et al., 2005).”
BackgroundVallon, V., Mühlbauer, B., & Oßwald, H. (2006) · Physiological Reviews · doi:10.1152/physrev.00031.2005 · Cited by 450 · see citing works
Self-citationHypertension in infancy: diagnosis, management and outcome
Dionne, J. M., Abitbol, C. L., & Flynn, J. T. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1755-z · Cited by 275 · see citing works
Caffeine analogs: biomedical impact
Daly, J. W. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7051-9 · Cited by 259 · see citing works
Caffeine for Apnea of Prematurity Trial: Benefits May Vary in Subgroups
Davis, P. G., Schmidt, B. K., Roberts, R. S., Doyle, L. W., Asztalos, E. V., Haslam, R. R., Sinha, S. K., & Tin, W. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2009.09.069 · Cited by 228 · see citing works
Caffeine as a factor influencing the functioning of the human body-friend or foe?
Rodak, K., Kokot, I., & Kratz, E. M. (2021) · Nutrients · doi:10.3390/nu13093088 · Cited by 188 · see citing works
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2016) · Molecules · doi:10.3390/molecules21080974 · Cited by 189 · see citing works
Rieg, T., Bundey, R. A., Chen, Y., Deschênes, G., JUNGER, W. G., Insel, P. A., & Vallon, V. (2007) · The FASEB Journal · doi:10.1096/fj.07-8807com · Cited by 175 · see citing works
Self-citationThe role of the BK channel in potassium homeostasis and flow-induced renal potassium excretion
Rieg, T., Vallon, V., Sausbier, M., Sausbier, U., Kaissling, B., Ruth, P., & Oßwald, H. (2007) · Kidney International · doi:10.1038/sj.ki.5002369 · Cited by 163 · see citing works
Self-citationRieg, T., Gerasimova, M., Murray, F., Masuda, T., Tang, T., Rose, M. A., Drucker, D. J., & Vallon, V. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00259.2012 · Cited by 160 · see citing works
Self-citationCaffeine therapy in preterm infants
Abdel‐Hady, H. (2015) · World Journal of Clinical Pediatrics · doi:10.5409/wjcp.v4.i4.81 · Cited by 157 · see citing works
A review on coffee leaves: Phytochemicals, bioactivities and applications
Chen, X. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1546667 · Cited by 138 · see citing works
Caffeine in preterm infants: where are we in 2020?
Moschino, L., Zivanovic, S., Hartley, C., Trevisanuto, D., Baraldi, E., & Roehr, C. C. (2020) · ERJ Open Research · doi:10.1183/23120541.00330-2019 · Cited by 133 · see citing works
Xanthine scaffold: scope and potential in drug development
Singh, N., Shreshtha, A. K., Thakur, M. S., & Patra, S. (2018) · Heliyon · doi:10.1016/j.heliyon.2018.e00829 · Cited by 131 · see citing works
High versus low-dose caffeine for apnea of prematurity: a randomized controlled trial
Mohammed, S., Nour, I., Shabaan, A. E., Shouman, B., Abdel‐Hady, H., & Nasef, N. (2015) · European Journal of Pediatrics · doi:10.1007/s00431-015-2494-8 · Cited by 116 · see citing works
Yang, S., Yang, R., Li, G., Qu, L., Li, J., & Yu, L. (2009) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2009.11.025 · Cited by 115 · see citing works
Adenosine Receptors and the Kidney
Vallon, V., & Oßwald, H. (2009) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-89615-9_15 · Cited by 114 · see citing works
Self-citationCoffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study
Yuan, S., & Larsson, S. C. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2021.04.018 · Cited by 113 · see citing works
Pharmacological potential of methylxanthines: Retrospective analysis and future expectations
Monteiro, J., Alves, M. G., Oliveira, P. F., & Silva, B. M. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1461607 · Cited by 103 · see citing works
Lin, B., Lin, M., Huang, R.-H., Hong, Y., Lin, B., & He, X. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01925-3 · Cited by 95 · see citing works
Caffeine and diuresis during rest and exercise: A meta-analysis
Zhang, Y., Coca, A., Casa, D. J., António, J., Green, J. M., & Bishop, P. A. (2014) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2014.07.017 · Cited by 94 · see citing works
Vallon, V., Schroth, J., Satriano, J. A., Blantz, R. C., Thomson, S. C., & Rieg, T. (2009) · Nephron Physiology · doi:10.1159/000208211 · Cited by 90 · see citing works
Self-citationRieg, T., Tang, T., Murray, F., Schroth, J., Insel, P. A., Fenton, R. A., Hammond, H. K., & Vallon, V. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010040409 · Cited by 90 · see citing works
Self-citationGiacoppo, D., Gargiulo, G., Buccheri, S., Aruta, P., Byrne, R. A., Cassese, S., Dangas, G., Kastrati, A., Mehran, R., Tamburino, C., et al. (2017) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.116.004383 · Cited by 88 · see citing works
Methylxanthines and the Kidney
Oßwald, H., & Schnermann, J. B. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_15 · Cited by 83 · see citing works
Self-citationMediators of tubuloglomerular feedback regulation of glomerular filtration: ATP and adenosine
Castrop, H. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01610.x · Cited by 82 · see citing works
Adenosine and Kidney Function: Potential Implications in Patients with Heart Failure
Vallon, V., Miracle, C., & Thomson, S. C. (2008) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2008.01.010 · Cited by 79 · see citing works
Self-citationCoffee consumption and risk of hypertension: a dose–response meta-analysis of prospective studies
D’Elia, L., Fata, E. L., Galletti, F., Scalfi, L., & Strazzullo, P. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1591-z · Cited by 77 · see citing works
Huang, D. Y., Vallon, V., Zimmermann, H., Koszałka, P., Schrader, J., & Oßwald, H. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00113.2005 · Cited by 74 · see citing works
Self-citationGuessous, I., Dobrinas, M., Kutalik, Z., Pruijm, M., Ehret, G., Maillard, M., Bergmann, S., Beckmann, J. S., Cusi, D., Rizzi, F., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds137 · Cited by 70 · see citing works
Vila-Luna, S., Cabrera-Isidoro, S., Vila-Luna, L., Juárez-Díaz, I., Bata-García, J. L., Álvarez-Cervera, F. J., Zapata-Vázquez, R., Arankowsky-Sandoval, G., Heredia-López, F., Flores, G., et al. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.11.053 · Cited by 71 · see citing works
Inhibition of Cyclic Nucleotide Phosphodiesterases by Methylxanthines and Related Compounds
Francis, S. H., Sekhar, K. R., Ke, H., & Corbin, J. D. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_4 · Cited by 68 · see citing works
Habibi, B., Abazari, M., & Pournaghi‐Azar, M. H. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.09.026 · Cited by 67 · see citing works
Blood Pressure in Relation to Coffee and Caffeine Consumption
Guessous, I., Eap, C. B., & Bochud, M. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0468-2 · Cited by 67 · see citing works
A Carbon Nanotube Modified Electrode for Determination of Caffeine by Differential Pulse Voltammetry
Habibi, B., Abazari, M., & Pournaghi-Azar, M. H. (2012) · CHINESE JOURNAL OF CATALYSIS (CHINESE VERSION) · doi:10.1016/s1872-2067(11)60438-5 · Cited by 66 · see citing works
Barghouthy, Y., Corrales, M., Doizi, S., Somani, B. K., & Traxer, O. (2020) · World Journal of Urology · doi:10.1007/s00345-020-03466-8 · Cited by 64 · see citing works
Caffeine-induced diuresis and natriuresis is independent of renal tubular NHE3
Fenton, R. A., Poulsen, S. B., Chavez, S. D. L. M., Soleimani, M., Busslinger, M., Dominguez, J. A., & Rieg, T. (2015) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00129.2015 · Cited by 62 · see citing works
Self-citationATP and adenosine in the local regulation of water transport and homeostasis by the kidney
Rieg, T., & Vallon, V. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90784.2008 · Cited by 59 · see citing works
Self-citationPerformance outcomes and unwanted side effects associated with energy drinks
Mora‐Rodríguez, R., & Pallarés, J. G. (2014) · Nutrition Reviews · doi:10.1111/nure.12132 · Cited by 56 · see citing works
Deb, P. K., Deka, S., Borah, P., Abed, S. N., & Klotz, K. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190716100509 · Cited by 54 · see citing works
Caffeine in Kidney Stone Disease: Risk or Benefit?
Peerapen, P., & Thongboonkerd, V. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy016 · Cited by 51 · see citing works
Liu, M., Wu, J., Gao, M., Li, Y., Xia, W., Zhang, Y., Chen, J., Chen, Z., Zhu, Z., & Chen, H. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1240171 · Cited by 48 · see citing works
P2Y2receptor activation decreases blood pressure and increases renal Na+excretion
Rieg, T., Gerasimova, M., Boyer, J. L., Insel, P. A., & Vallon, V. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00148.2011 · Cited by 48 · see citing works
Self-citationThomas, L., Xue, J., Murali, S. K., Fenton, R. A., Dominguez, J. A., & Rieg, T. (2019) · Journal of the American Society of Nephrology · doi:10.1681/asn.2018121250 · Cited by 48 · see citing works
Self-citationMethylxanthines During Pregnancy and Early Postnatal Life
Ådén, U. (2010) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-13443-2_14 · Cited by 45 · see citing works
António, J., Newmire, D. E., Stout, J. R., Antonio, B. B., Gibbons, M., Lowery, L. M., Harper, J., Willoughby, D. S., Evans, C., Anderson, D., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2323919 · Cited by 48 · see citing works
Varani, K., Vincenzi, F., Merighi, S., Gessi, S., & Borea, P. A. (2017) · Advances in experimental medicine and biology · doi:10.1007/5584_2017_61 · Cited by 43 · see citing works
Mécanismes de l’effet diurétique de la caféine
Marx, B., Scuvée, É., Scuvée‐Moreau, J., Seutin, V., & Jouret, F. (2016) · médecine/sciences · doi:10.1051/medsci/20163205015 · Cited by 40 · see citing works
Caffeine and the Kidney: What Evidence Right Now?
Bolignano, D., Coppolino, G., Barillà, A., Campo, S., Criseo, M., Tripodo, D., & Buemi, M. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2007.02.006 · Cited by 39 · see citing works
Associations of Ambulatory Blood Pressure With Urinary Caffeine and Caffeine Metabolite Excretions
Guessous, I., Pruijm, M. T., Ponte, B., Ackermann, D., Ehret, G., Ansermot, N., Vuistiner, P., Staessen, J. A., Gu, Y., Paccaud, F. M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04512 · Cited by 36 · see citing works
Habibi, B., Jahanbakhshi, M., & Abazari, M. (2013) · Journal of the Iranian Chemical Society · doi:10.1007/s13738-013-0324-3 · Cited by 35 · see citing works
mPGES-1 deletion impairs diuretic response to acute water loading
Soodvilai, S., Jia, Z., Wang, M.-H., Dong, Z., & Yang, T. (2009) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.90478.2008 · Cited by 35 · see citing works
Caffeine intake antagonizes salt sensitive hypertension through improvement of renal sodium handling
Yu, H., Yang, T., Gao, P., Wei, X., Zhang, H., Xiong, S., Lu, Z., Li, L., Wei, X., Chen, J., et al. (2016) · Scientific Reports · doi:10.1038/srep25746 · Cited by 34 · see citing works
Physiologically Based Pharmacokinetic/Pharmacodynamic Model for Caffeine Disposition in Pregnancy
Darakjian, L. I., & Kaddoumi, A. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01276 · Cited by 34 · see citing works
Adenosine and renal tubular function
Sole, F. D. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e32830321e1 · Cited by 32 · see citing works
Caffeinated Coffee Consumption or Abstinence to Reduce Atrial Fibrillation
Wong, C. X. J., Cheung, C. C., Montenegro, G., Oo, H. H., Peña, I. J., Tang, J. J., Tu, S. J., Wall, G. C., Dewland, T. A., Moss, J. D., et al. (2025) · JAMA · doi:10.1001/jama.2025.21056 · Cited by 31 · see citing works
Adenosine Receptors Influence Hypertension in Dahl Salt-Sensitive Rats
Jackson, E. K., Gillespie, D. G., Mi, Z., & Cheng, D. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10765 · Cited by 30 · see citing works
Effect of Black Tea Consumption on Urinary Risk Factors for Kidney Stone Formation
Siener, R., & Hesse, A. (2021) · Nutrients · doi:10.3390/nu13124434 · Cited by 30 · see citing works
Pharmacotherapy in Bronchopulmonary Dysplasia: What Is the Evidence?
Sakaria, R. P., & Dhanireddy, R. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.820259 · Cited by 30 · see citing works
Renal Autocrine and Paracrine Signaling: A Story of Self-protection
Leipziger, J., & Prætorius, H. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00014.2019 · Cited by 28 · see citing works
Kobayashi, S., Sata, F., Murata, K., Saijo, Y., Araki, A., Miyashita, C., Itoh, S., Minatoya, M., Yamazaki, K., Bamai, Y. A., et al. (2019) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12551 · Cited by 26 · see citing works
Adenosine, type 1 receptors: role in proximal tubule Na+reabsorption
Welch, W. J. (2014) · Acta Physiologica · doi:10.1111/apha.12413 · Cited by 24 · see citing works
Drug interactions of cola-containing drinks
Nomani, H., Moghadam, A. T., Emami, S. A., Mohammadpour, A. H., Johnston, T. P., & Sahebkar, A. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.01.029 · Cited by 23 · see citing works
Singh, H., Singh, H., Sahajpal, N., Paul, S., Kaur, I., & Jain, S. K. (2020) · Drug and Chemical Toxicology · doi:10.1080/01480545.2020.1833904 · Cited by 23 · see citing works
Dominguez, J. A., Burt, J. M., Ruth, P., & Rieg, T. (2014) · Acta Physiologica · doi:10.1111/apha.12446 · Cited by 22 · see citing works
Self-citationTajima, Y. (2010) · Clinical Medicine Insights: Case Reports · doi:10.4137/ccrep.s4329 · Cited by 22 · see citing works
Barghouthy, Y., Corrales, M., Doizi, S., Somani, B. K., & Traxer, O. (2021) · World Journal of Urology · doi:10.1007/s00345-020-03561-w · Cited by 21 · see citing works
Caffeine and bronchopulmonary dysplasia: Clinical benefits and the mechanisms involved
Yuan, Y., Yang, Y., Lei, X., & Dong, W. (2022) · Pediatric Pulmonology · doi:10.1002/ppul.25898 · Cited by 21 · see citing works
New functions and roles of the Na+-H+-exchanger NHE3
Rieg, J. D. D., & Rieg, T. (2024) · Pflügers Archiv: European Journal of Physiology · doi:10.1007/s00424-024-02938-9 · Cited by 16 · see citing works
Self-citationAdenosine1 Receptor Antagonism
Shah, R. H., & Frishman, W. H. (2009) · Cardiology in Review · doi:10.1097/crd.0b013e31819f1a98 · Cited by 21 · see citing works
Reuter, S. E., Schultz, H. B., Ward, M., Grant, C. L., Paech, G. M., Banks, S., & Evans, A. M. (2021) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14856 · Cited by 20 · see citing works
Ming, Z., & Lautt, W. W. (2010) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y10-090 · Cited by 20 · see citing works
Thomas, L., Xue, J., Tomilin, V. N., Pochynyuk, O. M., Rieg, J. A. D., & Rieg, T. (2020) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00146.2020 · Cited by 20 · see citing works
Self-citationWu, S. E., & Chen, W. (2020) · Nutrients · doi:10.3390/nu12092803 · Cited by 20 · see citing works
Caffeine intake in pregnancy: relationship between internal intake and effect on birth weight
Partosch, F., Mielke, H., Stahlmann, R., & Gundert-Remy, U. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.11.005 · Cited by 19 · see citing works
Oluwole, O. F., Salami, S. A., Ogunwole, E., & Raji, Y. (2016) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2015-0134 · Cited by 19 · see citing works
Rieg, T., Pothula, K., Schroth, J., Satriano, J. A., Oßwald, H., Schnermann, J. B., Insel, P. A., Bundey, R. A., & Vallon, V. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00344.2007 · Cited by 19 · see citing works
Self-citationCoffee and cardiovascular disease
Dewland, T. A., van Dam, R. M., & Marcus, G. M. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf421 · Cited by 18 · see citing works
Physiologic changes of urinary proteome by caffeine and excessive water intake
Peerapen, P., Ausakunpipat, N., Sutthimethakorn, S., Aluksanasuwan, S., Vinaiphat, A., & Thongboonkerd, V. (2016) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2016-0464 · Cited by 17 · see citing works
Miracle, C. M., Rieg, T., Blantz, R. C., Vallon, V., & Thomson, S. C. (2007) · Kidney & Blood Pressure Research · doi:10.1159/000108625 · Cited by 16 · see citing works
Self-citationAcrolein-Trapping Mechanism of Theophylline in Green Tea, Coffee, and Cocoa: Speedy and Successful
Jiang, X., Zhang, D., Lu, Y., & Lv, L. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03895 · Cited by 16 · see citing works
Mukdasai, K., & Mukdasai, S. (2017) · International Journal of Electrochemical Science · doi:10.20964/2018.01.39 · Cited by 16 · see citing works
Adenosine A1 receptors determine effects of caffeine on total fluid intake but not caffeine appetite
Rieg, T., Schnermann, J. B., & Vallon, V. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.10.039 · Cited by 15 · see citing works
Self-citationCaffeine intake and the risk of incident kidney stones: a systematic review and meta-analysis
Zhao, J., Huang, Y., & Yu, X. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03295-1 · Cited by 15 · see citing works
Theophylline Improves Early Allograft Function in Rat Kidney Transplantation
Grenz, A., Baier, D., Petroktistis, F., Wehrmann, M., Köhle, C., Schenk, M., Sessler, M. J., Gleiter, C. H., Fändrich, F., & Oßwald, H. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.096917 · Cited by 14 · see citing works
Chlorogenic Acid and Caffeine in Coffee Restore Insulin Signaling in Pancreatic Beta Cells.
Ihara, Y., Asahara, S., Inoue, H., Seike, M., Ando, M., Kabutoya, H., Kimura-Koyanagi, M., & Kido, Y. (2023) · PubMed Central · doi:10.24546/0100480554 · Cited by 12 · see citing works
Contribution of NHE3 and dietary phosphate to lithium pharmacokinetics
Thomas, L., Xue, J., Dominguez, J. A., & Rieg, T. (2018) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2018.11.008 · Cited by 12 · see citing works
Self-citationOral ketamine induced pathological changes of the urinary tract in a rat model.
Rajandram, R., Ny, Y., Ong, T., Ks, M., Ha, M. W., Hasan, M. S., Razack, A. H. A., & Mohd, M. A. (2017) · PubMed · Cited by 12 · see citing works
Wang, L., Fan, W., Cui, L., Yang, N., Zhang, X., Yu, S., Li, Y., & Wang, B. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05008 · Cited by 11 · see citing works
Gene–environment interactions of selected pharmacogenes in arterial hypertension
Bochud, M., & Guessous, I. (2012) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.12.58 · Cited by 11 · see citing works
Glomerular tubular balance is suppressed in adenosine type 1 receptor-deficient mice
Bell, T. D., Luo, Z., & Welch, W. J. (2010) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00202.2010 · Cited by 10 · see citing works
Serum potassium level as a biomarker for acute caffeine poisoning
Tsuji, T., Morita, S., Saito, T., Nakagawa, Y., & Inokuchi, S. (2020) · Acute Medicine & Surgery · doi:10.1002/ams2.568 · Cited by 8 · see citing works
Dual Effect of Adenosine A1Receptor Activation on Renal O2Consumption
Babich, V., Vadnagara, K., & Sole, F. D. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25050 · Cited by 8 · see citing works
Gonzalez, A. M., Guimarães, V., Figueiredo, N., Queiroz, M. D. O., Gentil, P., Mota, J. F., & Pimentel, G. D. (2020) · BioMed Research International · doi:10.1155/2020/6598753 · Cited by 8 · see citing works
Adenosine receptor antagonism in acute tacrolimus toxicity
McLaughlin, G. E., Alva, M. D., & Egea, M. (2006) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfl082 · Cited by 8 · see citing works
Molecular Mechanism of Caffeine in Preventing Bronchopulmonary Dysplasia in Premature Infants
Tian, C., Li, D., & Fu, J. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.902437 · Cited by 7 · see citing works
Kiremit, M. C., Böyük, A., & Petkova, K. (2023) · World Journal of Urology · doi:10.1007/s00345-023-04285-3 · Cited by 7 · see citing works
Aaryashree, A., Ohishi, T., & Yoshimi, Y. (2022) · Molecules · doi:10.3390/molecules27082456 · Cited by 6 · see citing works
Belló, C., Prestes, A. P., Schemberger, J. A., Hacke, A. C. M., Pereira, R. P., Manente, F. A., Carlos, I. Z., de Andrade, C. R., Fernandes, D., da Cruz, I. B. M., et al. (2020) · Journal of Food Biochemistry · doi:10.1111/jfbc.13560 · Cited by 6 · see citing works
Zhang, S., Liu, H., Wang, L., Li, Z., & Wang, B. (2021) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc202105020 · Cited by 6 · see citing works
- Authors
- Rieg, T., Steigele, H., Schnermann, J., Richter, K., Osswald, H., & Vallon, V.
- Affiliations
- University of Tübingen (DE)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 313
- Issue
- 1
- Pages
- 403-409
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2134391819
- Cited by
- 133
- References
- 43
- Citations by year
- 2025: 9 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 19 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 4
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- adenosine A1 receptor, theophylline, caffeine, methylxanthines, diuresis, sodium excretion, tubular reabsorption, phosphodiesterase inhibition, urinary excretion
- MeSH terms
- Anesthesia, Animals, Caffeine, Diuretics, Genotype, Glomerular Filtration Rate, Mice, Inbred C57BL, Natriuresis, Potassium, Sodium, Theophylline, Urodynamics, Mice, Knockout, Receptor, Adenosine A1, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
