Expression of cannabinoid CB1 receptors in models of diabetic neuropathy
Abstract
A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this complication of diabetes. In the present study we investigated the expression of cannabinoid CB(1) receptors in models of diabetic neuropathy. PC12 cells were differentiated into a neuronal phenotype with nerve growth factor (NGF) (50 ng/ml) in varying concentrations of glucose (5.5-50 mM). CB(1) receptor expression was studied at the mRNA level by reverse transcriptase-polymerase chain reaction (RT-PCR) and at the protein level via immunohistochemical and Western blot analysis. CB(1) expression was also compared in dorsal root ganglia (DRG) removed from streptozotocin-induced diabetic rats versus control animals. Total neurite length induced by NGF was reduced in cells cultured in 20 to 50 mM glucose at day 6 (P < 0.01 versus 5.5 mM; n = 6). Cell viability assays conducted in parallel on day 6 confirmed that the total cell numbers were not significantly different among the various glucose concentrations (P = 0.86; n = 12). RT-PCR, immunohistochemical, and Western blot analysis all revealed down-regulation of the CB(1) receptor in cells treated with high glucose (P < 0.05; n = 4-5 for each), and in DRG removed from diabetic rats compared with controls (P < 0.01; n = 5 for immunohistochemistry, and n = 3 for Western blot). These results suggest that high glucose concentrations are associated with decreased expression of CB(1) receptors in nerve cells. Given the neuroprotective effect of cannabinoids, a decline in CB(1) receptor expression may contribute to the neurodegenerative process observed in diabetes.
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Diabetic rats exhibit a decrease in the density of CB1 receptor protein in dorsal root ganglia.
“Diabetic rats exhibit a decrease in the density of CB1 receptor protein in DRG.108”
From Cannabinoids as Pharmacotherapies for Neuropathic Pain: From the Bench to the Bedside (2009) · cites this paper as [108]
Cites
1 retracted
Ahluwalia, J., Yaqoob, M., Urbán, L., Bevan, S., & Nagy, I. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01550.x · Cited by 82 · see citing works
RetractedWild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. J. (1997) · Nature · doi:10.1038/39807 · Cited by 9,132 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142 · see citing works
Induction of vanilloid receptor channel activity by protein kinase C
Premkumar, L. S., & Ahern, G. P. (2000) · Nature · doi:10.1038/35050121 · Cited by 801 · see citing works
Scheen, A. J., Finer, N., Hollander, P. A., Jensen, M. D., & Gaal, L. F. V. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69571-8 · Cited by 729 · see citing works
Activation of the peripheral endocannabinoid system in human obesity
Engeli, S., Böhnke, J., Feldpausch, M., Gorzelniak, K., Janke, J., Bátkai, S., Pacher, P., Harvey-White, J., Luft, F. C., Sharma, A. M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2838 · Cited by 686 · cited 2× · see citing works
“In obese postmenopausal women with fasting hyperinsulinemia, elevated levels of anandamide and 2-arachidonoylglycerol were found to be associated with decreased CB1 receptor expression in adipose tissue (Engeli et al., 2005).”
Matias, I., Gonthier, M., Orlando, P., Martiadis, V., PETROCELLIS, L. D., Cervino, C., Petrosino, S., Hoareau, L., Festy, F., Pasquali, R., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2679 · Cited by 654 · see citing works
Numazaki, M., Tominaga, T., Toyooka, H., & Tominaga, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200104200 · Cited by 466 · see citing works
Neurons Undergo Apoptosis in Animal and Cell Culture Models of Diabetes
Russell, J. W., Sullivan, K. A., Windebank, A. J., Herrmann, D. N., & Feldman, E. L. (1999) · Neurobiology of Disease · doi:10.1006/nbdi.1999.0254 · Cited by 411 · see citing works
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
Ahluwalia, J. P., Urbán, L., Capogna, M., Bevan, S., & Nagy, I. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00389-4 · Cited by 302 · see citing works
Antihyperalgesic effects of spinal cannabinoids
Richardson, J. D., Aanonsen, L., & Hargreaves, K. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01621-x · Cited by 275 · see citing works
A role for mitogen‐activated protein kinases in the etiology of diabetic neuropathy
Purves-Tyson, T. D., Middlemas, A. B., Agthong, S., Jude, E. B., Boulton, A. J. M., Fernyhough, P., & Tomlinson, D. R. (2001) · The FASEB Journal · doi:10.1096/fj.01-0253hyp · Cited by 274 · see citing works
Hong, S., Morrow, T., Paulson, P. E., Isom, L. L., & Wiley, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404167200 · Cited by 268 · see citing works
Self-citationHong, S., & Wiley, J. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408500200 · Cited by 235 · see citing works
Self-citationInfluence of Metabolic Syndrome on Biomarkers of Oxidative Stress and Inflammation in Obese Adults
Guilder, G. P. V., Hoetzer, G. L., Greiner, J. J., Stauffer, B. L., & DeSouza, C. A. (2006) · Obesity · doi:10.1038/oby.2006.248 · Cited by 211 · see citing works
Cannabinoid Receptors and Their Role in Neuroprotection
van der Stelt, M., & Marzo, V. D. (2005) · NeuroMolecular Medicine · doi:10.1385/nmm:7:1-2:037 · Cited by 189 · see citing works
Ahluwalia, J., Urbán, L., Bevan, S., & Nagy, I. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02703.x · Cited by 181 · see citing works
Bridges, D., Rice, A. S. C., Egertová, M., Elphick, M. R., Winter, J., & Michael, G. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00200-8 · Cited by 173 · see citing works
Diabetic neuropathies: clinical manifestations and current treatment options
Vinik, A. I., Ullal, J., Parson, H. K., & CASELLINI, C. M. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0142 · Cited by 172 · see citing works
Denovan‐Wright, E. M., & Robertson, H. A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00157-3 · Cited by 169 · see citing works
Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor
Garcı́a, D. E., Brown, S. M., Hille, B., & Mackie, K. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02834.1998 · Cited by 154 · see citing works
Glass, M., van Dellen, A., Blakemore, C. B., Hannan, A. J., & Faull, R. L. M. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00595-5 · Cited by 136 · see citing works
Rashid, M. H., Inoue, M., Bakoshi, S., & Ueda, H. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.050948 · Cited by 123 · see citing works
Ahlgren, S. C., & Levine, J. D. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.72.2.684 · Cited by 122 · see citing works
Activation of cannabinoid CB1 receptors induces glucose intolerance in rats
Bermúdez‐Silva, F. J., Serrano, A., Diaz-Molina, F. J., Sánchez-Vera, I., Juan-Picó, P., Nadal, Á., Fuentes, E., & de Fonseca, F. R. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.016 · Cited by 109 · see citing works
Zhuang, S.-Y., Kittler, J. T., Grigorenko, E. V., Kirby, M. T., Sim, L. J., Hampson, R. E., Childers, S. R., & Deadwyler, S. A. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00232-0 · Cited by 109 · see citing works
Bisogno, T., Katayama, K., Melck, D. J., Ueda, N., PETROCELLIS, L. D., Yamamoto, S., & Marzo, V. D. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2540634.x · Cited by 94 · see citing works
Matias, I., Wang, J. W., Moriello, A. S., Nieves, A., Woodward, D. F., & Di Marzo, V. (2006) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2006.08.002 · Cited by 89 · see citing works
Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice
Kamei, J., Zushida, K., Morita, K., Sasaki, M., & Tanaka, S. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01059-7 · Cited by 87 · see citing works
Silverdale, M., McGuire, S., McInnes, A., Crossman, A. R., & Brotchie, J. M. (2001) · Experimental Neurology · doi:10.1006/exnr.2001.7649 · Cited by 80 · see citing works
Ellington, H. C., Cotter, M. A., Cameron, N. E., & Ross, R. A. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00040-0 · Cited by 79 · see citing works
Smith, P., & McQueen, D. S. (2001) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704296 · Cited by 63 · see citing works
Self-citationTargeting the endocannabinoid system in treating brain disorders
Bahr, B. A., Karanian, D. A., Makanji, S. S., & Makriyannis, A. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.15.4.351 · Cited by 56 · see citing works
Lelkes, E., Unsworth, B. R., & Lelkes, P. I. (2001) · Neurotoxicity Research · doi:10.1007/bf03033191 · Cited by 47 · see citing works
Shindo, H., Thomas, T., Larkin, D. D., Karihaloo, A. K., Inada, H., Onaya, T., Stevens, M. J., & Greene, D. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118472 · Cited by 41 · see citing works
Duarte, J. M. N., Nogueira, C., Mackie, K., Oliveira, C. R., Cunha, R. A., & Köfalvi, A. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.11.013 · Cited by 38 · see citing works
Expression of vanilloid VR1 receptor in PC12 cells
Someya, A., Kunieda, K., Akiyama, N., Hirabayashi, T., Horie, S., & Murayama, T. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.06.002 · Cited by 20 · see citing works
Millns, P. J., Chimenti, M., Ali, N., Ryland, E., de Lago, E., Fernández‐Ruíz, J., Chapman, V., & Kendall, D. A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05236.x · Cited by 19 · see citing works
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Rahn, E. J., & Hohmann, A. G. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.08.002 · Cited by 305 · see citing works
The Role of the Endocannabinoid System in Pain
Woodhams, S. G., Sagar, D. R., Burston, J. J., & Chapman, V. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-46450-2_7 · Cited by 205 · see citing works
Toth, C., Mawani, S., Brady, S., Chan, C., Liu, C., Mehina, E., Garven, A., Bestard, J., & Korngut, L. (2012) · Pain · doi:10.1016/j.pain.2012.06.024 · Cited by 174 · see citing works
The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
Horváth, B., Mukhopadhyay, P., Haskó, G., & Pacher, P. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.003 · Cited by 152 · see citing works
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Kremer, A. E., Feramisco, J. D., Reeh, P. W., Beuers, U. H., & Elferink, R. P. J. O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.007 · Cited by 93 · see citing works
Harvey, B. S., Ohlsson, K. S., Mååg, J. L. V., Musgrave, I. F., & Smid, S. D. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2011.12.015 · Cited by 82 · see citing works
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Sagar, D. R., Burston, J. J., Woodhams, S. G., & Chapman, V. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0390 · Cited by 76 · see citing works
Lim, J. C., Lim, S. K., Han, H. J., & Park, S. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22255 · Cited by 73 · see citing works
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Laprairie, R. B., Kelly, M. M., & Denovan‐Wright, E. M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02175.x · Cited by 69 · see citing works
Veress, G., Mészár, Z., Muszil, D., Avelino, A., Matesz, K., Mackie, K., & Nagy, I. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0425-2 · Cited by 67 · see citing works
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Borowska, M., Czarnywojtek, A., Sawicka‐Gutaj, N., Woliński, K., Płazińska, M. T., Mikołajczak, P. Ł., & Ruchała, M. (2018) · Endokrynologia Polska · doi:10.5603/ep.a2018.0072 · Cited by 66 · see citing works
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Burston, J. J., & Woodhams, S. G. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003650 · Cited by 65 · see citing works
Lever, I. J., Robinson, M., Cibelli, M., Paule, C. C., Sántha, P., Yee, L., Hunt, S. P., Cravatt, B. F., Elphick, M. R., Nagy, I., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-08.2009 · Cited by 63 · see citing works
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Lim, J. C., Lim, S. K., Park, M. J., Kim, G.-Y., Han, H. J., & Park, S. H. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00032.2010 · Cited by 49 · see citing works
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Jenkin, K. A., McAinch, A. J., Zhang, Y., Kelly, D. J., & Hryciw, D. H. (2014) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12355 · Cited by 38 · see citing works
Schreiber, A. K., Neufeld, M., Jesus, C. H. A., & da Cunha, J. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.009 · Cited by 35 · see citing works
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Zhang, F., Challapalli, S. C., & Smith, P. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.04.017 · Cited by 33 · see citing works
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Rahimian, R., Dehpour, A. R., Fakhfouri, G., Khorramizadeh, M. R., Ghia, J., Seyedabadi, M., Caldarelli, A., Mousavizadeh, K., Forouzandeh, M., & Mehr, S. E. (2011) · Brain Research · doi:10.1016/j.brainres.2011.08.050 · Cited by 28 · see citing works
Chen, A. C. H., Lee, Y. L., Fong, S. W., Wong, C. C. Y., Ng, E. H. Y., & Yeung, W. S. B. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2583-2 · Cited by 24 · see citing works
Kalvala, A. K., Yerra, V. G., & Kumar, A. (2019) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104695 · Cited by 23 · see citing works
Bujalska, M. (2008) · Pharmacology · doi:10.1159/000156485 · Cited by 20 · see citing works
Coşkun, Z. M., & Bolkent, S. (2014) · Cell Biochemistry and Function · doi:10.1002/cbf.3058 · Cited by 19 · see citing works
Li, Y., Sun, Y., Zhang, Z., Feng, X., Meng, H., Li, S., Zhu, Y., Chen, S., Wang, Y., Wang, J., et al. (2013) · British Journal of Urology · doi:10.1111/bju.12172 · Cited by 17 · see citing works
Mohammadi-Farani, A., Ghazi‐Khansari, M., & Sahebgharani, M. (2014) · Europe PMC (PubMed Central) · Cited by 15 · see citing works
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RetractedNabemoto, M., Mashimo, M., Someya, A., Nakamura, H., Hirabayashi, T., Fujino, H., Kaneko, M., Okuma, Y., Saito, T., Yamaguchi, N., et al. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.04.064 · Cited by 14 · see citing works
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Leal, E. C., Moura, L. I. F., Pirzgalska, R. M., Marques‐da‐Silva, D., Ledent, C. A., Köfalvi, A., & Carvalho, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111528 · Cited by 12 · see citing works
Proteomic analysis of human proximal tubular cells exposed to high glucose concentrations
So, E.-J., Kim, H., & Kim, C. (2008) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200780151 · Cited by 12 · see citing works
Effects of the endocannabinoid transport inhibitors AM404 and UCM707 on diabetic neuropathy in rats
Hasanein, P., & Soltani, N. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05197.x · Cited by 11 · see citing works
Reduced Endocannabinoid Tone in Saliva of Chronic Orofacial Pain Patients
Haviv, Y., Georgiev, O., Gaver-Bracha, T., Hamad, S., Nemirovski, A., Hadar, R., Sharav, Y., Aframian, D. J., Brotman, Y., & Tam, J. (2022) · Molecules · doi:10.3390/molecules27144662 · Cited by 9 · see citing works
Moura, L. I. F., Lemos, C., Ledent, C. A., Carvalho, E., & Köfalvi, A. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.024 · Cited by 6 · see citing works
Pedro, J. R., Moura, L. I. F., Valério-Fernandes, Â., Baptista, F. I., Gaspar, J. M., Pinheiro, B. S., Lemos, C., Kaufmann, F. N., Morgado, C., da Silva-Santos, C. S., et al. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.05.004 · Cited by 4 · see citing works
Pruritus in diabetes mellitus (DM) and its pathophysiology-based treatment
Wijaya, L., Melanie, A., Veronica, V., & Christy, G. (2022) · Journal of the Medical Sciences (Berkala Ilmu Kedokteran) · doi:10.19106/jmedsci005401202210 · Cited by 2 · see citing works
Tehranipour, M., Shahri, N. M., Koushki, A., & Mousavi, B. Z. J. (2012) · مجله علمی پژوهشی افق دانش
Laprairie, R. B. (2012) · Library and Archives Canada (Government of Canada)
Kremer, A. E., & Weißhaar, E. (2016) · Springer eBooks · doi:10.1007/978-3-319-33142-3_35
Weißhaar, E. (2009) · Springer eBooks · doi:10.1007/978-1-84882-322-8_29
- Authors
- Zhang, F., Hong, S., Stone, V., & Smith, P. J. W.
- Affiliations
- Edinburgh Napier University (GB)
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 323
- Issue
- 2
- Pages
- 508-515
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2113184132
- Cited by
- 46
- References
- 40
- Citations by year
- 2022: 3 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 9
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- CB1 receptor, diabetic neuropathy, high glucose, nerve growth factor, PC12 cells, dorsal root ganglia, streptozotocin-induced diabetes, neurite outgrowth, receptor down-regulation, neuroprotection, neurodegeneration
- MeSH terms
- Animals, Diabetic Neuropathies, Male, RNA, Messenger, Neurites, PC12 Cells, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB1, TRPV Cation Channels, Rats
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