Antitumorigenic effects of cannabinoids beyond apoptosis.
Abstract
According to the World Health Organization, the cases of death caused by cancer will have been doubled until the year 2030. By 2010, cancer is expected to be the number one cause of death. Therefore, it is necessary to explore novel approaches for the treatment of cancer. Over past years, the antitumorigenic effects of cannabinoids have emerged as an exciting field in cancer research. Apart from their proapoptotic and antiproliferative action, recent research has shown that cannabinoids may likewise affect tumor cell angiogenesis, migration, invasion, adhesion, and metastasization. This review will summarize the data concerning the influence of cannabinoids on these locomotive processes beyond modulation of cancer cell apoptosis and proliferation. The findings discussed here provide a new perspective on the antitumorigenic potential of cannabinoids.
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Evidence is accumulating for endocannabinoid involvement in conditions involving growth of pathological tissue or tissue transplantation.
“Indeed, evidence is accumulating for endocannabinoid involvement in some of these conditions [15,24,40]”
From Endocannabinoid involvement in endometriosis. (2010) · cites this paper as [15]
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- Authors
- Freimuth, N., Ramer, R., & Hinz, B.
- Affiliations
- University of Rostock (DE)
- ORCID
- Hinz, Burkhard
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 332
- Issue
- 2
- Pages
- 336-344
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2144309900
- Cited by
- 71
- References
- 75
- Citations by year
- 2025: 2 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 9 · 2014: 7 · 2013: 2 · 2012: 11
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- cannabinoids, anti-tumorigenic effects, tumor angiogenesis, tumor cell migration, tumor invasion, cell adhesion, metastasis, apoptosis, cell proliferation, cancer therapy
- MeSH terms
- Animals, Antineoplastic Agents, Cannabinoids, Cell Adhesion, Cell Movement, Humans, Models, Biological, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Apoptosis, Angiogenesis Inhibitors
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