Cited by 135Neuroprotection in Cerebral IschemiaNerve injury and regenerationPharmacological Receptor Mechanisms and Effects

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4 H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair

Ferzaz, Badia, Brault, Emmanuel, Bourliaud, Genevieve, Robert, Jean-Pierre, Poughon, Gilles, Claustre, Yves, Marguet, Franck, Liere, Philippe, Schumacher, Michael, Nowicki, Jean-Pierre, Fournier, Jacqueline, Marabout, Benoit, Sevrin, Mireille, George, Pascal, Soubrie, Philippe, Benavides, Jesus, Scatton, Bernard·2002·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1124/jpet.301.3.1067

Open this paper in CoChat — free account

Abstract

In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand, 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575), in models of central and peripheral neurodegeneration in vivo and its effect on steroid concentrations in plasma and nervous tissue. SSR180575 shows high affinity (IC(50), 2.5-3.5 nM) and selectivity for the rat and human PBR and potently inhibits the in vivo binding of [(3)H]alpidem to PBR in the rat brain and spleen after oral or i.p. administration (ID(50), 0.1-0.3 mg/kg). In an experimental model of motoneuron degeneration induced by facial nerve axotomy in the immature rat, SSR180575 given i.p. or orally for 8 days rescued facial motoneurons, increasing their survival by 40 to 72% at 6 and 10 mg/kg p.o. b.i.d. Moreover, in this model, SSR180575 (10 mg/kg p.o. b.i.d.) increased by 87% the number of motoneurons immunoreactive to peripherin, a type III intermediate filament, whose expression is up-regulated during nerve regeneration. SSR180575 also improved functional recovery in acrylamide-induced neuropathy in the rat when given therapeutically at 2.5 to 10 mg/kg/day p.o. Furthermore, SSR180575 (3 mg/kg i.p. b.i.d.) accelerated functional recovery of the blink reflex after local injury of the facial nerve in the rat. SSR180575 increased pregnenolone accumulation in the brain and sciatic nerve (+100% at 3 mg/kg i.p.), suggesting…

Integrity signals

Registry

Crossref · 10.1124/jpet.301.3.1067

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.
DeLÉAN, A., Munson, P. J., & Rodbard, D. (1978) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1978.235.2.e97 · Cited by 2,384
THE MITOCHONDRIAL DEATH/LIFE REGULATOR IN APOPTOSIS AND NECROSIS
Kroemer, G., Dallaporta, B., & Resche-Rigon, M. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.619 · Cited by 1,975
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,203
Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier
McEnery, M. W., Snowman, A. M., Trifiletti, R. R., & Snyder, S. H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3170 · Cited by 708
The peripheral-type benzodiazepine receptor. Localization to the mitochondrial outer membrane.
Anholt, R. R. H., Pedersen, P. L., Souza, E. B. D., & Snyder, S. H. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36131-8 · Cited by 696
Progesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480
Self-citation
Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D2/D3 Receptor Antagonist with Both Presynaptic and Limbic Selectivity
Schoemaker, H., Claustre, Y., Fage, D., Rouquier, L., Chergui, K., Curet, O., Oblin, A., Gonon, F., Carter, C. J., Bénavidès, J., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36395-5 · Cited by 371
Self-citation
Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies.
Brattsand, R., & Linden, M. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.22164025.x · Cited by 361
Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells
Krueger, K. E., & Papadopoulos, V. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77217-7 · Cited by 345
Specific high-affinity binding sites for [3H]Ro 5-4864 in rat brain and kidney.
Schoemaker, H., Boles, R. G., Horst, W. D., & Yamamura, H. I. (1983) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)33552-4 · Cited by 294

Show all 41 references

Sorted by citations

Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders
Rupprecht, R., Papadopoulos, V., Rammes, G., Baghai, T. C., Fan, J., Akula, N., Groyer, G., Adams, D., & Schumacher, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3295 · Cited by 930
Self-citation
Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair
Chen, M.-K., & Guilarte, T. R. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.12.004 · Cited by 506
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers
Chauveau, F., Boutin, H., Camp, N. V., Dollé, F., & Tavitian, B. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0908-9 · Cited by 419
The facial nerve axotomy model
Moran, L. B., & Graeber, M. B. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.11.004 · Cited by 310
Identification and Characterization of Cholest-4-en-3-one, Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
Bordet, T., Buisson, B., Michaud, M., Drouot, C., Galéa, P., Delaage, P., Akentieva, N., Evers, A. S., Covey, D. F., Ostuni, M. A., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.123000 · Cited by 267
Self-citation
Channel-Like Functions of the 18-kDa Translocator Protein (TSPO): Regulation of Apoptosis and Steroidogenesis as Part of the Host-Defense Response
Veenman, L., Papadopoulos, V., & Gavish, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781368710 · Cited by 249
Progesterone: Therapeutic opportunities for neuroprotection and myelin repair
Schumacher, M., Guennoun, R., Stein, D. G., & Nicola, A. F. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.001 · Cited by 247
Self-citation
Neuroactive steroids: State of the art and new perspectives
Melcangi, R. C., García‐Segura, L. M., & Mensah‐Nyagan, A. G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7403-5 · Cited by 249
The peripheral-type benzodiazepine receptor and the cardiovascular system. Implications for drug development
Veenman, L., & Gavish, M. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.007 · Cited by 192
Translocator protein (18 kDa) TSPO: An emerging therapeutic target in neurotrauma
Papadopoulos, V., & Lecanu, L. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.016 · Cited by 178
Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies
Ji, B., Maeda, J., Sawada, M., Ono, M., Okauchi, T., Inaji, M., Zhang, M.-R., Suzuki, K., Ando, K., Staufenbiel, M., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2312-08.2008 · Cited by 169
Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System
Schumacher, M., Guennoun, R., Ghoumari, A. M., Massaad, C., Robert, F., El‐Etr, M., Akwa, Y., Rajkowski, K. M., & Baulieu, É.-É. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0050 · Cited by 170
Self-citation
A TSPO ligand is protective in a mouse model of multiple sclerosis
Daugherty, D. J., Selvaraj, V., Chechneva, O. V., Liu, X., Pleasure, D., & Deng, W. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202124 · Cited by 158
Etifoxine improves peripheral nerve regeneration and functional recovery
Girard, C., Liu, S., Cadepond, F., Adams, D., Lacroix, C., Verleye, M., Gillardin, J., Baulieu, É.-É., Schumacher, M., & Schweizer-Groyer, G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811201106 · Cited by 152
Self-citation
[11C]DAA1106: radiosynthesis and in vivo binding to peripheral benzodiazepine receptors in mouse brain
Zhang, M., Kida, T., Noguchi, J., Furutsuka, K., Maeda, J., Suhara, T., & Suzuki, K. (2003) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(03)00016-7 · Cited by 144
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization
Chen, M., Baidoo, K. E., Verina, T., & Guilarte, T. R. (2004) · Brain · doi:10.1093/brain/awh161 · Cited by 140
Antianxiety and antidepressant‐like effects of AC‐5216, a novel mitochondrial benzodiazepine receptor ligand
Kita, A., Kohayakawa, H., Kinoshita, T., Ochi, Y., Nakamichi, K., Kurumiya, S., Furukawa, K., & Oka, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705681 · Cited by 124
Novel lipoidal derivatives of pregnenolone and dehydroepiandrosterone and absence of their sulfated counterparts in rodent brain
Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Liu, S., Griffiths, W., Schumacher, M., Sjövall, J., & Baulieu, E.-E. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400244-jlr200 · Cited by 118
Self-citation
The Translocator Protein (18 kDa): Central Nervous System Disease and Drug Design
Scarf, A. M., Ittner, L. M., & Kassiou, M. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm8011678 · Cited by 98
Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity
Veiga, S., Azcoitia, I., & Garcia-Segura, L. M. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20430 · Cited by 101
Neuroactive steroids and peripheral neuropathy
Roglio, I., Giatti, S., Pesaresi, M., Bianchi, R., Cavaletti, G., Lauria, G., García‐Segura, L. M., & Melcangi, R. C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.04.010 · Cited by 92
Cognitive Enhancers (Nootropics). Part 1: Drugs Interacting with Receptors
Froestl, W., Muhs, A., & Pfeifer, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121186 · Cited by 94
Neuroprotective effects of a ligand of translocator protein-18kDa (Ro5-4864) in experimental diabetic neuropathy
Giatti, S., Pesaresi, M., Cavaletti, G., Bianchi, R., Carozzi, V., Lombardi, R., Maschi, O., Lauria, G., García‐Segura, L. M., Caruso, D., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.005 · Cited by 89
Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?
Bonsack, F., Alleyne, C. H., & Sukumari‐Ramesh, S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0619-2 · Cited by 98
Microglial Pro-Inflammatory and Anti-Inflammatory Phenotypes Are Modulated by Translocator Protein Activation
Pozzo, E. D., Tremolanti, C., Costa, B., Giacomelli, C., Milenkovic, V. M., Bader, S. M., Wetzel, C. H., Rupprecht, R., Taliani, S., Settimo, F. D., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184467 · Cited by 89
Role of Peripheral Benzodiazepine Receptors in Mitochondrial, Cellular, and Cardiac Damage Induced by Oxidative Stress and Ischemia-Reperfusion
Leducq, N., Bono, F., Sulpice, T., Vin, V., Janiak, P., Fur, G. L., O'Connor, S., & Herbert, J. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.052068 · Cited by 86
Steroidogenic acute regulatory protein in the brain
Lavaque, E., Sierra, A., Azcoitia, I., & Garcia-Segura, L. M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.05.060 · Cited by 81
Axonal Regeneration and Neuroinflammation: Roles for the Translocator Protein 18 kDa
Girard, C., Liu, S., Adams, D., Lacroix, C., Sinéus, M., Boucher, C., Papadopoulos, V., Rupprecht, R., Schumacher, M., & Groyer, G. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02215.x · Cited by 75
Self-citation
Oxidative Imbalance and Anxiety Disorders
Krolow, R., Arcego, D. M., Noschang, C. G., Weis, S. N., & Dalmaz, C. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120223530 · Cited by 76
Imaging the Peripheral Benzodiazepine Receptor Response in Central Nervous System Demyelination and Remyelination
Chen, M., & Guilarte, T. R. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj172 · Cited by 70
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy
Costa, B., Pozzo, E. D., Giacomelli, C., Barresi, E., Taliani, S., Settimo, F. D., & Martini, C. (2016) · Scientific Reports · doi:10.1038/srep18164 · Cited by 73
Immunohistochemical Assessment of the Peripheral Benzodiazepine Receptor in Human Tissues
Bribes, E., Carrière, D., Goubet, C., Galiègue, S., Casellas, P., & Joêlle, S.-L. (2004) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540405200103 · Cited by 65
In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)
Chauveau, F., Boutin, H., Camp, N. V., Thominiaux, C., Hantraye, P., Rivron, L., Marguet, F., Castel, M., Rooney, T., Bénavidès, J., et al. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1628-5 · Cited by 61
Self-citation
TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis
Lejri, I., Grimm, A., Hallé, F., Abarghaz, M., Klein, C., Maître, M., Schmitt, M., Bourguignon, J., Mensah‐Nyagan, A. G., Bihel, F. J. ‐., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190127 · Cited by 68
An update on pharmacological approaches to neurodegenerative diseases
Scatena, R., Martorana, G. E., Bottoni, P., Botta, G., Pastore, P., & Giardina, B. (2006) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.1.59 · Cited by 62
Estradiol Modulates Translocator Protein (TSPO) and Steroid Acute Regulatory Protein (StAR) via Protein Kinase A (PKA) Signaling in Hypothalamic Astrocytes
Chen, C., Kuo, J., Wong, A., & Micevych, P. E. (2014) · Endocrinology · doi:10.1210/en.2013-1844 · Cited by 57
Axonal injury‐dependent induction of the peripheral benzodiazepine receptor in small‐diameter adult rat primary sensory neurons
Karchewski, L. A., Bloechlinger, S., & Woolf, C. J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03530.x · Cited by 56
Translocator protein (18 kDa) (TSPO) as a therapeutic target for anxiety and neurologic disorders
Nothdurfter, C., Baghai, T. C., Schüle, C., & Rupprecht, R. (2012) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-012-0352-5 · Cited by 60
Sex differences in steroid levels and steroidogenesis in the nervous system: Physiopathological role
Giatti, S., Diviccaro, S., Serafini, M. M., Caruso, D., García‐Segura, L. M., Viviani, B., & Melcangi, R. C. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100804 · Cited by 60
An update into the medicinal chemistry of translocator protein (TSPO) ligands
Barresi, E., Robello, M., Costa, B., Pozzo, E. D., Baglini, E., Salerno, S., Settimo, F. D., Martini, C., & Taliani, S. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112924 · Cited by 59
Role of Neuroactive Steroids in the Peripheral Nervous System
Melcangi, R. C., Giatti, S., Pesaresi, M., Calabrese, D., Mitro, N., Caruso, D., & García‐Segura, L. M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00104 · Cited by 51
Neuroactive steroids and the peripheral nervous system: An update
Giatti, S., Romano, S., Pesaresi, M., Cermenati, G., Mitro, N., Caruso, D., Tetel, M. J., García‐Segura, L. M., & Melcangi, R. C. (2015) · Steroids · doi:10.1016/j.steroids.2015.03.014 · Cited by 50
Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury
O'Brien, E. S., Gauthier, D., Riban, V., & Verleye, M. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0687-3 · Cited by 58
Peripheral benzodiazepine receptor ligand, PK11195 induces mitochondria cytochrome c release and dissipation of mitochondria potential via induction of mitochondria permeability transition
Li, J., Wang, J., & Zeng, Y.-M. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.12.027 · Cited by 47
On the Role of the Translocator Protein (18-kDa) TSPO in Steroid Hormone Biosynthesis
Papadopoulos, V. (2013) · Endocrinology · doi:10.1210/en.2013-2033 · Cited by 49
Induced expressions of Rab24 GTPase and LC3 in nerve-injured motor neurons
Egami, Y., Kiryu‐Seo, S., Yoshimori, T., & Kiyama, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.171 · Cited by 45
Translocator protein (TSPO) ligands for the diagnosis or treatment of neurodegenerative diseases: a patent review (2010–2015; part 1)
Kim, T., & Pae, A. N. (2016) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2016.1230606 · Cited by 47
Effects of progesterone on neuropathic pain responses in an experimental animal model for peripheral neuropathy in the rat: A behavioral and electrophysiological study
Jarahi, M., Sheibani, V., Safakhah, H. A., Torkmandi, H., & Rashidy‐Pour, A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.043 · Cited by 43
Role of the peripheral benzodiazepine receptor in sensory neuron regeneration
Mills, C. D., Bitler, J. L., & Woolf, C. J. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.07.010 · Cited by 42
Targeting the 18-kDa translocator protein: recent perspectives for neuroprotection
Pozzo, E. D., Giacomelli, C., Barresi, E., Costa, B., Taliani, S., Settimo, F. D., & Martini, C. (2015) · Biochemical Society Transactions · doi:10.1042/bst20150028 · Cited by 41
Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats
Leonelli, E., Yagüe, J. G., Ballabio, M., Azcoitia, Í., Magnaghi, V., Schumacher, M., García‐Segura, L. M., & Melcangi, R. C. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.001 · Cited by 41
Self-citation
Current status and future perspectives: TSPO in steroid neuroendocrinology
Selvaraj, V., & Tu, L. N. (2016) · Journal of Endocrinology · doi:10.1530/joe-16-0241 · Cited by 41
Potent neuroprotective role of novel melatonin derivatives for management of central neuropathy induced by acrylamide in rats
Ahmed, H. H., Elmegeed, G. A., El-Sayed, E.-S. M., Abdelhalim, M. M., Shousha, W. G., & Shafic, R. W. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.09.017 · Cited by 39
TSPO Radioligands for Neuroinflammation: An Overview
Salerno, S., Viviano, M., Baglini, E., Poggetti, V., Giorgini, D., Castagnoli, J., Barresi, E., Castellano, S., Settimo, F. D., & Taliani, S. (2024) · Molecules · doi:10.3390/molecules29174212 · Cited by 41
Binding characteristics of SSR180575, a potent and selective peripheral benzodiazepine ligand
Vin, V., Leducq, N., Bono, F., & Herbert, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.079 · Cited by 36
Ro5‐4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats
Mills, C., Makwana, M., Wallace, A., Benn, S., Schmidt, H., Tegeder, I., Costigan, M., Brown, R. H., Raivich, G., & Woolf, C. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06065.x · Cited by 35
Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging
Viviano, M., Barresi, E., Siméon, F. G., Costa, B., Taliani, S., Settimo, F. D., Pike, V. W., & Castellano, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220329204054 · Cited by 35
Therapeutic approaches to peripheral neuropathy based on neuroactive steroids
Melcangi, R. C., & García‐Segura, L. M. (2006) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.6.8.1121 · Cited by 32
Molecular Imaging of the Translocator Protein (TSPO) in a Pre-Clinical Model of Breast Cancer
Wyatt, S. K., Manning, H. C., Bai, M., Bailey, S. N., Gallant, P., Ma, G., McIntosh, L. M., & Bornhop, D. J. (2009) · Molecular Imaging and Biology · doi:10.1007/s11307-009-0270-8 · Cited by 31
Development of new indole-derived neuroprotective agents
Mohareb, R. M., Ahmed, H. H., Elmegeed, G. A., Abdelhalim, M. M., & Shafic, R. W. (2011) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2011.03.031 · Cited by 31
18F-Radiolabeled Translocator Protein (TSPO) PET Tracers: Recent Development of TSPO Radioligands and Their Application to PET Study
Luu, T. G., & Kim, H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112545 · Cited by 32
Translocator protein in the rise and fall of central nervous system neurons
Cheung, G., Lin, Y. C., & Papadopoulos, V. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1210205 · Cited by 33
Etifoxine provides benefits in nerve repair with acellular nerve grafts
Zhou, X., He, B., Zhu, Z., He, X., Zheng, C., Xu, J., Jiang, L., Gu, L., Zhu, J., Zhu, Q., et al. (2013) · Muscle & Nerve · doi:10.1002/mus.24131 · Cited by 29
The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Barichello, T., Simões, L. R., Collodel, A., Giridharan, V. V., Dal‐Pizzol, F., Macêdo, D. S., & Quevedo, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.010 · Cited by 30
Progesterone: Synthesis, Metabolism, Mechanism of Action, and Effects in the Nervous System
Schumacher, M., Zhu, X., & Guennoun, R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00054-7 · Cited by 30
Self-citation
Antioxidant Activity and Neuroprotective Effects of Zolpidem and Several Synthesis Intermediates
García‐Santos, G., Herrera, F., Martı́n, V., Rodríguez‐Blanco, J., Antolı́n, I., Fernández-Marı́, F., & Rodrı́guez, C. (2004) · Free Radical Research · doi:10.1080/10715760400017343 · Cited by 28
Evaluating the Phase II drugs currently under investigation for diabetic neuropathy
Adeghate, E. A., Fehér, E., & Kalász, H. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.954033 · Cited by 28
Synthesis and Structure–Activity Relationship Studies in Translocator Protein Ligands Based on a Pyrazolo[3,4-b]quinoline Scaffold
Cappelli, A., Bini, G., Valenti, S., Giuliani, G., Paolino, M., Anzini, M., Vomero, S., Giorgi, G., Giordani, A., Stasi, L. P., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200770f · Cited by 27
Ligands of the peripheral benzodiazepine receptor have therapeutic effects in pneumopathies in vivo
Bribes, E., Bourrié, B., & Casellas, P. (2003) · Immunology Letters · doi:10.1016/s0165-2478(03)00083-x · Cited by 27
Facile synthesis of SSR180575 and discovery of 7-chloro-N,N,5-trimethyl-4-oxo-3(6-[18F]fluoropyridin-2-yl)-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, a potent pyridazinoindole ligand for PET imaging of TSPO in cancer
Cheung, Y., Nickels, M. L., Tang, D., Buck, J. R., & Manning, H. C. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.07.091 · Cited by 26
Neuroactive Steroids: A Therapeutic Approach to Maintain Peripheral Nerve Integrity During Neurodegenerative Events
Leonelli, E., Ballabio, M., Consoli, A., Roglio, I., Magnaghi, V., & Melcangi, R. C. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:28:1:65 · Cited by 26
Roles of Mitochondrial Benzodiazepine Receptor in the Heart
Surinkaew, S., Chattipakorn, S. C., & Chattipakorn, N. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.12.023 · Cited by 27
Mechanisms of Repair after Traumatic Injury
HALL, S. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50061-2 · Cited by 25
An efficient synthesis of novel 1,3-oxazolo[4,5- d ]pyridazinones
Frolov, E. B., Lakner, F. J., Khvat, A. V., & Ivachtchenko, A. V. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.04.093 · Cited by 25
Metal complexes targeting the Translocator Protein 18 kDa (TSPO)
Denora, N., Iacobazzi, R. M., Natile, G., & Margiotta, N. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.03.023 · Cited by 24
Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice
Bribes, E., Bourrié, B., Esclangon, M., Galiègue, S., Vidal, H., & Casellas, P. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)02231-8 · Cited by 24
The mitochondrial translocator protein (TSPO): a key multifunctional molecule in the nervous system
Chemali, L. E., Akwa, Y., & Massaad-Massade, L. (2022) · Biochemical Journal · doi:10.1042/bcj20220050 · Cited by 30
In Vivo Imaging of Glial Activation after Unilateral Labyrinthectomy in the Rat: A [18F]GE180-PET Study
Zwergal, A., Gunther, L. M., Brendel, M., Beck, R., Lindner, S., Xiong, G., Eilles, E., Unterrainer, M., Albert, N. L., Becker‐Bense, S., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00665 · Cited by 22
Targeting Neuroprotection as an Alternative Approach to Preventing and Treating Neuropathic Pain
Bordet, T., & Pruss, R. M. (2009) · Neurotherapeutics · doi:10.1016/j.nurt.2009.07.001 · Cited by 24
In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC
Yanamoto, K., Kumata, K., Fujinaga, M., Nengaki, N., Takei, M., Wakizaka, H., Hosoi, R., Momosaki, S., Yamasaki, T., Yui, J., et al. (2010) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2010.04.183 · Cited by 22
Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor
Yu, W., Wang, E., Voll, R. J., Miller, A. H., & Goodman, M. M. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.04.046 · Cited by 21
Agnosic vision is like peripheral vision, which is limited by crowding
Strappini, F., Pelli, D. G., Pace, E. D., & Martelli, M. (2017) · Cortex · doi:10.1016/j.cortex.2017.01.012 · Cited by 22
Etifoxine promotes glial-derived neurotrophic factor-induced neurite outgrowth in PC12 cells
Zhou, X., HE, X., He, B., Zhu, Z., Zheng, C., Xu, J., Jiang, L., Gu, L., Zhu, J., Zhu, Q., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1474 · Cited by 20
Radiosynthesis of 7‐chloro‐N,N‐dimethyl‐5‐[11C]methyl‐4‐oxo‐3‐phenyl‐3,5‐dihydro‐4H‐pyridazino[4,5‐b]indole‐1‐acetamide, [11C]SSR180575, a novel radioligand for imaging the TSPO (peripheral benzodiazepine receptor) with PET
Thominiaux, C., Damont, A., Kühnast, B., Demphel, S., Helleix, S. L., Boisnard, S., Rivron, L., Chauveau, F., Boutin, H., Camp, N. V., et al. (2010) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.1794 · Cited by 20
Translocator protein agonist Ro5-4864 alleviates neuropathic pain and promotes remyelination in the sciatic nerve
Ma, B., Liu, X., Huang, X., Ji, Y. S., Jin, T., & Ma, K. (2017) · Molecular Pain · doi:10.1177/1744806917748019 · Cited by 19
Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem
Cappelli, A., Giuliani, G., Valenti, S., Anzini, M., Vomero, S., Giorgi, G., Sogliano, C., Maciocco, E., Biggio, G., & Concas, A. (2007) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2007.06.044 · Cited by 18
Expression of the Peripheral Benzodiazepine Receptor Triggers Thymocyte Differentiation
Rochard, P., Galiègue, S., Tinel, N., Péleraux, A., Bord, A., Jbilo, O., & Casellas, P. (2004) · Gene Expression · doi:10.3727/000000004783992170 · Cited by 18
Synthesis of N‐(2,5‐dimethoxybenzyl)‐N‐(5‐fluoro‐2‐phenoxyphenyl)[carbonyl‐11C]acetamide ([carbonyl‐11C]DAA1106) and analogues using [11C]carbon monoxide and palladium(0) complex
Rahman, O., & Långström, B. (2007) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.1437 · Cited by 18
Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
Vicente-Rodríguez, M., Mancuso, R., Peris-Yague, A., Simmons, C., NIMA Consortium, Wlazly, D., Dickinson, A., Foster, A., Knight, C., Leckey, C., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02769-y · Cited by 17
The Ligands of Translocator Protein: Design and Biological Properties
Мокров, Г. В., Деева, О. А., & Гудашева, Т. А. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200903122025 · Cited by 18
Brain steroidogenesis: emerging therapeutic strategies to prevent neurodegeneration
Azcoitia, Í., Sierra, A., Veiga, S. J., & García‐Segura, L. M. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0179-y · Cited by 17
Peripheral benzodiazepine receptors on platelets of fibromyalgic patients
Bazzichi, L., Giannaccini, G., Betti, L., Italiani, P., Fabbrini, L., DeFeo, F. G., Giacomelli, C., Giuliano, T., Rossi, A., Uccelli, A., et al. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.06.002 · Cited by 16
Investigation Into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy
Belair, D. G., Sudak, K., Connelly, K., Collins, N. D., Kopytek, S., & Kolaja, K. L. (2021) · Toxicological Sciences · doi:10.1093/toxsci/kfab033 · Cited by 14
A Protective Role of Translocator Protein in Alzheimer’s Disease Brain
Jung, M. E. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666200217105950 · Cited by 17
Discovery of Imidazoquinazolinone Derivatives as TSPO Ligands Modulating Neurosteroidogenesis and Cellular Bioenergetics in Neuroblastoma Cells Expressing Amyloid Precursor Protein
Hallé, F., Lejri, I., Abarghaz, M., Grimm, A., Klein, C., Maître, M., Schmitt, M., Bourguignon, J., Mensah‐Nyagan, A. G., Eckert, A., et al. (2017) · ChemistrySelect · doi:10.1002/slct.201701565 · Cited by 17
Design, synthesis and structure–activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands
Fukaya, T., Kodo, T., Ishiyama, T., Nishikawa, H., Baba, S., & Masumoto, S. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.12.024 · Cited by 13
TNF-alpha induced PMN apoptosis in whole human blood: Protective effect of SSR180575, a potent and selective peripheral benzodiazepine ligand
Leducq, N., Vin, V., Savi, P., & Bono, F. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.07.011 · Cited by 13
Involvement of the peripheral benzodiazepine receptor in the development of cutaneous pathology in Mrl/Lpr mice
Bribes, E., Galiègue, S., Bourrié, B., & Casellas, P. (2003) · Immunology Letters · doi:10.1016/s0165-2478(02)00177-3 · Cited by 13
The mitochondrial translocator protein (TSPO) in Alzheimer's disease: Therapeutic and immunomodulatory functions
Fairley, L. H., Lai, K. O., Grimm, A., Eckert, A., & Barron, A. M. (2024) · Biochimie · doi:10.1016/j.biochi.2024.07.003 · Cited by 14
A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration
Bloms‐Funke, P., Schumacher, M., Liu, S., Su, D., Li, J., Lière, P., Rupprecht, R., Nothdurfter, C., Bahrenberg, G., Christoph, T., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174935 · Cited by 14
Self-citation

Authors: Ferzaz, B., Brault, E., Bourliaud, G., Robert, J.-P., Poughon, G., Claustre, Y., Marguet, F., Liere, P., Schumacher, M., Nowicki, J.-P., Fournier, J., Marabout, B., Sevrin, M., George, P., Soubrie, P., Benavides, J., & Scatton, B.
Affiliations: Sanofi (France) (FR)
ORCID: Scatton, Bernard
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 2002-06
Volume: 301
Issue: 3
Pages: 1067-1078
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1124/jpet.301.3.1067
OpenAlex: W2155301275
Cited by: 126
References: 41
Citations by year: 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 4 · 2017: 7 · 2016: 11 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 3
FWCI: 5.38
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Receptor Mechanisms and Effects
Keywords: translocator protein (TSPO), neuroprotection, motor neuron degeneration, facial nerve axotomy, pregnenolone, peripherin, nerve regeneration, functional recovery, blink reflex
MeSH terms: Acetamides, Aging, Animals, Binding, Competitive, Cell Survival, Facial Nerve, Humans, Imidazoles, Indoles, Ligands, Male, Motor Neurons, Pyridazines, Pyridines, Receptors, GABA-A, Anti-Anxiety Agents, Rats, Sprague-Dawley, Neuroprotective Agents, Axotomy, Rats, GABA-A Receptor Agonists, GABA-A Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

SSR180575 (7-Chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4 H-pyridazino[4,5-b]indole-1-acetamide), a Peripheral Benzodiazepine Receptor Ligand, Promotes Neuronal Survival and Repair

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks