Role of the Agonist Binding Site in Up-Regulation of Neuronal Nicotinic α4β2 Receptors

The nicotinic receptor β2 subunit is mutant in nocturnal frontal lobe epilepsy

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Chronic Exposure to Nicotine Upregulates the Human α4β2 Nicotinic Acetylcholine Receptor Function

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Mutation Causing Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Alters Ca2+Permeability, Conductance, and Gating of Human α4β2 Nicotinic Acetylcholine Receptors

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Rat nicotinic ACh receptor α7 and β2 subunits co‐assemble to form functional heteromeric nicotinic receptor channels

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Upregulation of Surface α4β2 Nicotinic Receptors Is Initiated by Receptor Desensitization after Chronic Exposure to Nicotine

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Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

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Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons

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Human α4β2 Neuronal Nicotinic Acetylcholine Receptor in HEK 293 Cells: A Patch-Clamp Study

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Functional significance of aromatic amino acids from three peptide loops of the α7 neuronal nicotinic receptor site investigated by site‐directed mutagenesis

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The nicotinic receptor ligand binding domain

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Agonist-Induced Up-Regulation of α4β2 Nicotinic Acetylcholine Receptors in M10 Cells: Pharmacological and Spatial Definition

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Identification of a New Component of the Agonist Binding Site of the Nicotinic α7 Homooligomeric Receptor

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Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

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Regulation of Human α4β2 Neuronal Nicotinic Acetylcholine Receptors by Cholinergic Channel Ligands and Second Messenger Pathways

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Conserved tyrosines in the alpha subunit of the nicotinic acetylcholine receptor stabilize quaternary ammonium groups of agonists and curariform antagonists.

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Nicotine is Highly Effective at Producing Desensitization of Rat α4β2 Neuronal Nicotinic Receptors

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Pharmacology of Lobeline, A Nicotinic Receptor Ligand

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Changes in Conformation and Subcellular Distribution of α4β2 Nicotinic Acetylcholine Receptors Revealed by Chronic Nicotine Treatment and Expression of Subunit Chimeras

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Ligand Binding and Activation of Rat Nicotinic α4β2 Receptors Stably Expressed in HEK293 Cells

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Mutation (Ser284Leu) of neuronal nicotinic acetylcholine receptor α4 subunit associated with frontal lobe epilepsy causes faster desensitization of the rat receptor expressed in oocytes

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Ligand Binding Is a Critical Requirement for Plasma Membrane Expression of Heteromeric Kainate Receptors

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Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating

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Aromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the αY93 and αW149 residues

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Cytisine binds with similar affinity to nicotinic α4β2 receptors on the cell surface and in homogenates

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The Regulation of Hippocampal Nicotinic Acetylcholine Receptors (nAChRs) After a Protracted Treatment with Selective or Nonselective nAChR Agonists

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Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

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Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors

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Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

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Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery

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Assembly and trafficking of nicotinic acetylcholine receptors (Review)

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RIC‐3: a nicotinic acetylcholine receptor chaperone

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Nicotine: specific role in angiogenesis, proliferation and apoptosis

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Biogenesis, trafficking and up-regulation of nicotinic ACh receptors

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Inside-out neuropharmacology of nicotinic drugs

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Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype

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Pharmacological Chaperoning of Nicotinic Acetylcholine Receptors Reduces the Endoplasmic Reticulum Stress Response

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Structural answers and persistent questions about how nicotinic receptors work

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86Rb+ efflux mediated by α4β2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization

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The Nicotinic α5 Subunit Can Replace Either an Acetylcholine-Binding or Nonbinding Subunit in the α4β2* Neuronal Nicotinic Receptor

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Förster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic α4β2

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Long-term treatment with nicotine suppresses neurotoxicity of, and microglial activation by, thrombin in cortico-striatal slice cultures

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Tumor Necrosis Factor α Enhances Nicotinic Receptor Up-regulation via a p38MAPK-dependent Pathway

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Endogenously Expressed Muscarinic Receptors in HEK293 Cells Augment Up-regulation of Stably Expressed α4β2 Nicotinic Receptors

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Photoaffinity labeling the agonist binding domain of α4β4 and α4β2 neuronal nicotinic acetylcholine receptors with [125I]epibatidine and 5[125I]A-85380

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Neuronal Nicotinic Receptors in Sleep-Related Epilepsy: Studies in Integrative Biology

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Environmental Pollutants on Angiogenesis and Vascular Development

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Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding

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Expression and function of urothelial nicotinic acetylcholine receptors

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Identification and Characterization of Rare Variants in Cholinergic Nicotinic Receptor Genes and their Contribution to Substance Dependence

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"Principal Component Analysis and the Cumulative Gait Index: Translational Tools to Assess Gait Impairments in Rats with Olivocerebellar Ataxia"

Lambert, C. S. (2015) · Digital Commons - University of South Florida (University of South Florida)

TOWARDS AN UNDERSTANDING OF PHARMACOLOGICALLY INDUCED INTRACELLULAR CHANGES IN NICOTINIC ACETYLCHOLINE RECEPTORS

Fox-Loe, A. M. (2016) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2016.461

Impacts of Environmental Pollutants on Angiogenesis and Vascular Development

Zeng, X., Hong, X., & Sun, Q. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00176-5

Environmental Pollutants on Angiogenesis and Vascular Development

Hong, X., Zhang, L., & Sun, Q. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.14026-4

The role of β4-containing nicotinic acetylcholine receptors in nicotine addiction

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Regulation of Neuronal Nicotinic Receptor Expression by Novel Ligands and Mechanisms

Hussmann, G. P. (2012) · DigitalGeorgetown (Georgetown University Library)

Chronic Nicotine Exposure Upregulates Nicotinic Receptors by a Novel Mechanism

Vallejo, Y. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5240-04.2005 · Cited by 201 · see citing works

An extracellular protein microdomain controls up-regulation of neuronal nicotinic acetylcholine receptors by nicotine

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Agonist-induced up-regulation of alpha4beta2 nicotinic acetylcholine receptors in M10 cells: pharmacological and spatial definition.

Whiteaker, P., Sharples, C. G., & Wonnacott, S. (1998) · PubMed · doi:10.7270/q2b856pt · Cited by 147 · see citing works

Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways

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Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype

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