GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity

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Understanding the role of the NMDA receptor subunit, GluN2D , in mediating NMDA receptor antagonist‐induced behavioral disruptions in male and female mice

Vinnakota, C., Schroeder, A., Du, X., Ikeda, K., Ide, S., Mishina, M., Hudson, M. R., Jones, N. C., Sundram, S., & Hill, R. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25257 · Cited by 5

Inhibition of GluN2B-containing N -methyl- D- aspartate receptors by radiprodil

Banke, T. G., Regan, M. C., Perszyk, R. E., Zhang, L., Xing, H., Chen, J., Won, S., Simorowski, N., Diaz, E. S., Kim, S., et al. (2025) · Brain · doi:10.1093/brain/awaf355 · Cited by 6

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Wang, Y., Xu, J., Zhou, X., Che, L., Qiu, M., Liu, Y., Gao, M., & Yang, Z. (2025) · Advanced Science · doi:10.1002/advs.202516024 · Cited by 9

Selective enhancement of the interneuron network and gamma‐band power via GluN2C/GluN2D NMDA receptor potentiation

Camp, C. R., Banke, T. G., Xing, H., Yu, K., Perszyk, R. E., Epplin, M. P., Akins, N. S., Zhang, J., Benke, T. A., Yuan, H., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288343 · Cited by 8

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP

Zhu, M., Perkins, M. G., Lennertz, R. C., Abdulzahir, A., & Pearce, R. A. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109215 · Cited by 5

Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons

Rademacher, J., Grent-‘t-Jong, T., Rivolta, D., Sauer, A., Scheller, B., González‐Burgos, G., Metzner, C., & Uhlhaas, P. J. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013118 · Cited by 6

GluN2D expression is regulated by restraint stress and supports active stress coping bouts

Doyle, M. A., Brown, J. A., & Winder, D. G. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109377 · Cited by 5

GluN2D-containing NMDA receptors in parvalbumin neurons in the nucleus accumbens regulate nocifensive responses in neuropathic pain

Gakare, S. G., Shelkar, G. P., Gawande, D. Y., Pavuluri, R., Gandhi, P. J., & Dravid, S. M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106784 · Cited by 5

Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl- d -Aspartate Receptor

Fritzemeier, R. G., Akins, N. S., Arcoria, P. J., Paladugu, S., Ullman, E. Z., Allen, J. P., Sheikh, R., Nocilla, K. A., McDaniels, E. D., Coleman, E. M., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02912 · Cited by 5

Extending the Small Molecule Similarity Principle to All Levels of BiologyPreprint

Duran‐Frigola, M., Pauls, E., Guitart-Pla, O., Bertoni, M., Orozco-Ruiz, M., Alcalde, V., Diaz, V. M., Berenguer, A., Amat, D., Juan-Blanco, T., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3380254 · Cited by 6

The Effects of miR-22-3p on Differentiation of Human Dental Pulp Stem Cells into Neural Progenitor-Like Cells

Gul, M. T., Khattak, M. N. K., Qaisar, R., Jayakumar, M. N., Samsudin, A. B. R., & Khan, A. A. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04702-1 · Cited by 5

BNST G lu N 2 D ‐containing NMDAR s contribute to ethanol intake but not negative affective behaviors in female mice

Doyle, M. A., Salimando, G. J., Altemus, M. E., Badt, J. K., Bedenbaugh, M. N., Vardy, A. S., Adank, D. N., Park, A. S., & Winder, D. G. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15432 · Cited by 3

Glycine-gated extrasynaptic NMDARs activated during glutamate spillover drive burst firing in nigral dopamine neurons

Ringlet, S., Motta, Z., Vandries, L. M., Seutin, V., Jehasse, K., Caldinelli, L., Pollegioni, L., & Engel, D. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102773 · Cited by 3

Function of Excitatory Periaqueductal Gray Synapses in the Ventral Tegmental Area following Inflammatory Injury

Manning, C., Fritz, M., & Kauer, J. A. (2022) · eNeuro · doi:10.1523/eneuro.0324-22.2022 · Cited by 3

Selective Cell-Surface Expression of Triheteromeric NMDA Receptors

Yi, F., Traynelis, S. F., & Hansen, K. B. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3830-9_5 · Cited by 3

A Plate-Based Assay for the Measurement of Endogenous Monoamine Release in Acute Brain Slices

Pino, J. A., Awadallah, N., Norris, A. M., & Torres, G. E. (2021) · Journal of Visualized Experiments · doi:10.3791/62127 · Cited by 3

Loss of Grin2a Causes a Transient Delay in the Electrophysiological Maturation of Hippocampal Parvalbumin Interneurons: A Possible Mechanism for Transient Seizure Burden in Patients with Null GRIN2A VariantsPreprint

Camp, C. R., Vlachos, A., Klöckner, C., Krey, I., Banke, T. G., Shariatzadeh, N., Ruggiero, S. M., Galer, P. D., Park, K., Caccavano, A., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.29.474447 · Cited by 3

Deficiency of the histone lysine demethylase KDM5B causes autism-like phenotypes via increased NMDAR signallingPreprint

Pérez‐Sisqués, L., Bhatt, S., Caruso, A., Ahmed, M. U., Gileadi, T. E., Spring, S., Hendy, E., Taylor‐Papadimitriou, J., Cash, D., Clifton, N. E., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.28.596232 · Cited by 3

Exposure to alpha-glycosyl isoquercitrin from gestation to adulthood increases synaptic densities of glutamatergic and GABAergic inputs in the hippocampal dentate gyrus in rats

Tang, Q., Zou, X., Ojiro, R., Ozawa, S., Koyanagi, M., Maronpot, R. R., Yoshida, T., & Shibutani, M. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105990 · Cited by 2

Magnesium deficiency differentially modulates hippocampal and prefrontal oscillations and cardiac rhythms

Inoue, S., Ikegaya, Y., Matsumoto, N., & Kashima, T. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.12.002 · Cited by 2

Parsing the neuroanatomy of schizophrenia to enhance the translational validity of preclinical models - a multidisciplinary perspective

MORRIS, B. J. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111628 · Cited by 2

Preliminary Study About A Significant and Treatable Cause of Epileptic Encephalopathy: GRIN2D Mutation

Kutluk, G., & Randa, N. C. (2021) · Acta Medica Alanya · doi:10.30565/medalanya.891938 · Cited by 2

Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation

Xing, H., Banke, T. G., Zhang, L., Yu, K., Camp, C. R., Fritzemeier, R. G., Akins, N. S., Paladugu, S., Arcoria, P. J., Brady, B. R., et al. (2025) · The Journal of Physiology · doi:10.1113/jp289774 · Cited by 1

Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency

Pérez‐Sisqués, L., Bhatt, S. R., Caruso, A., Robb, J. L., Donovan, A. P. A., Bamford, R. A., Torres-Cano, A., Spring, S., Hendy, E., Gileadi, T. E., et al. (2026) · Science Advances · doi:10.1126/sciadv.adq6577 · Cited by 1

A cell type-specific switch in GluN2D NMDA receptors drives cortical circuit hyperexcitability and sensory-driven cortical synchronization deficits in a Fragile X Syndrome model.

Shedd, A., Jonak, C., Chan, L., Assad, S. A., Dravid, S., Gibson, J. R., Binder, D., & Huber, K. M. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.09.007 · Cited by 1

21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans

Watkins, J. C., Evans, R. H., Bayés, À., Booker, S. A., Gibb, A. J., Mabb, A. M., Mayer, M. L., Mellor, J. R., Molnár, E., Niu, L., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108743 · Cited by 2

GluN2D-containing NMDA receptors support dentate granule cell excitability, synaptic plasticity, and memoryPreprint

Berthoux, C., Rodenas-Ruano, A., Bist, L., Nasrallah, K., Castillo, M., Shelkar, G. P., Dravid, S. M., Swanger, S. A., & Castillo, P. E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.06.710109 · Cited by 1

GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice

Engelhardt, J. V., Bocklisch, C., Tönges, L., Herb, A., Mishina, M., & Monyer, H. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00095 · Cited by 103

Contribution of NMDA Receptors to Synaptic Function in Rat Hippocampal Interneurons

Booker, S. A., Sumera, A., Kind, P. C., & Wyllie, D. J. A. (2021) · eNeuro · doi:10.1523/eneuro.0552-20.2021 · Cited by 32

A Novel Negative Allosteric Modulator Selective for GluN2C/2D-Containing NMDA Receptors Inhibits Synaptic Transmission in Hippocampal Interneurons

Swanger, S. A., Vance, K. M., Acker, T. M., Zimmerman, S. S., DiRaddo, J. O., Myers, S. J., Bundgaard, C., Mosley, C. A., Summer, S. L., Menaldino, D. S., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00329 · Cited by 60

Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation

Xing, H., Banke, T. G., Zhang, L., Yu, K., Camp, C. R., Fritzemeier, R. G., Akins, N. S., Paladugu, S., Arcoria, P. J., Brady, B. R., et al. (2025) · The Journal of Physiology · doi:10.1113/jp289774 · Cited by 1

Selective enhancement of the interneuron network and gamma‐band power via GluN2C/GluN2D NMDA receptor potentiation

Camp, C. R., Banke, T. G., Xing, H., Yu, K., Perszyk, R. E., Epplin, M. P., Akins, N. S., Zhang, J., Benke, T. A., Yuan, H., et al. (2025) · The Journal of Physiology · doi:10.1113/jp288343 · Cited by 8