The DOI matches its Crossref record; 145 of the 145 references it cites were found in a registry or an index.
Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring
Open accessAbstract
Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity. Despite the enormous amount of research conducted in this area, the exact molecular mechanisms underlying DOX toxic effects on the heart are still an area that warrants further investigations. In this study, we reviewed literature to gather the best-known molecular pathways related to DOX-induced cardiotoxicity (DIC). They include mechanisms dependent on mitochondrial dysfunction such as DOX influence on the mitochondrial electron transport chain, redox cycling, oxidative stress, calcium dysregulation, and apoptosis pathways. Furthermore, we discuss the existing strategies to prevent and/or alleviate DIC along with various techniques available for therapeutic drug monitoring (TDM) in cancer patients treated with DOX. Finally, we propose a stepwise flowchart for TDM of DOX and present our perspective at curtailing this deleterious side effect of DOX.
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Cites
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Cited by
Wang, J., Li, M., Jin, L., Guo, P., Zhang, Z., Zhanghuang, C., Tan, X., Mi, T., Liu, J., Wu, X., et al. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2141921 · Cited by 60
Metadata
- Authors
- Wenningmann, N., Knapp, M., Ande, A., Vaidya, T. R., & Ait-Oudhia, S.
- Venue
- Molecular Pharmacology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 96
- Issue
- 2
- Pages
- 219-232
- ISSN
- 0026-895X (ISSN-L)
- OpenAlex
- W2948077402
- Cited by
- 334
- References
- 145
- FWCI
- 24.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wenningmann, N., Knapp, M., Ande, A., Vaidya, T. R., & Ait-Oudhia, S. (2019). Insights into Doxorubicin-induced Cardiotoxicity: Molecular Mechanisms, Preventive Strategies, and Early Monitoring. Molecular Pharmacology. https://doi.org/10.1124/mol.119.115725
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
