Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder

Differential Display PCR Reveals Novel Targets for the Mood-Stabilizing Drug Valproate Including the Molecular Chaperone GRP78

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Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder

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Dysregulation of C/EBPα by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

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Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons

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Valproate ameliorates the survival and the motor performance in a transgenic mouse model of Huntington's disease

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Differential epigenetic modifications in the FMR1 gene of the fragile X syndrome after reactivating pharmacological treatments

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Valproic Acid–induced Hepatopathy: Nine New Fatalities in Germany from 1994 to 2003

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Citicoline and lithium rescue retinal ganglion cells following partial optic nerve crush in the rat

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Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

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Involvement of the Glycogen Synthase Kinase-3 Signaling Pathway in TBI Pathology and Neurocognitive Outcome

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Valproic acid induces extracellular signal-regulated kinase 1/2 activation and inhibits apoptosis in endothelial cells

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Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin

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Regulation of glycogen synthase kinase‐3 during bipolar mania treatment

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SMN1 gene, but not SMN2 , is a risk factor for sporadic ALS

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A systematic study of brainstem motor nuclei in a mouse model of ALS, the effects of lithium

Ferrucci, M., Spalloni, A., Bartalucci, A., Cantafora, E., Fulceri, F., Nutini, M., Longone, P., Paparelli, A., & Fornai, F. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.017 · Cited by 87

Lithium Upregulates Vascular Endothelial Growth Factor in Brain Endothelial Cells and Astrocytes

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Therapeutic Angiogenesis for Brain Ischemia: A Brief Review

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Risk of Aplastic Anemia in Patients Using Antiepileptic Drugs

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Improvement of Huntington's Disease with Olanzapine and Valproate

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Mood stabilizing drug lithium increases expression of endoplasmic reticulum stress proteins in primary cultured rat cerebral cortical cells

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An investigation of the neuroprotective effect of lithium in organotypic slice cultures of rat hippocampus exposed to oxygen and glucose deprivation

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No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS

Gill, A., Kidd, J. D., Vieira, F. G., Thompson, K., & Perrin, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006489 · Cited by 83

Lithium Restores Neurogenesis in the Subventricular Zone of the Ts65Dn Mouse, a Model for Down Syndrome

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Brain Lithium Levels and Effects on Cognition and Mood in Geriatric Bipolar Disorder: A Lithium-7 Magnetic Resonance Spectroscopy Study

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Lithium and valproate prevent olfactory discrimination and short-term memory impairments in the intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rat model of Parkinson's disease

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Valproic acid‐mediated Hsp70 induction and anti‐apoptotic neuroprotection in SH‐SY5Y cells

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Neuroprotective effect and cognitive outcome of chronic lithium on traumatic brain injury in mice

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Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro

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Valproic acid-associated weight gain in older children and teens with epilepsy

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Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder

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Neuroprotective Mechanisms of Lithium in Murine Human Immunodeficiency Virus-1 Encephalitis

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KIAA0369, doublecortin-like kinase, is expressed during brain development

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Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury

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Active β-Catenin Signaling Is an Inhibitory Pathway for Human Immunodeficiency Virus Replication in Peripheral Blood Mononuclear Cells

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High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study

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Upregulation of GSK3β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci)

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Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: Protection by mood stabilizers and imipramine

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Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial

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Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia.

Hunsberger, J. G., Fessler, E. B., Wang, Z., ELKAHLOUN, A. G., & Chuang, D. (2012) · Europe PMC (PubMed Central) · Cited by 77

Valproic acid improves outcome after rodent spinal cord injury: Potential roles of histone deacetylase inhibition

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The Mood Stabilizers Valproic Acid and Lithium Enhance Mesenchymal Stem Cell Migration via Distinct Mechanisms

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The use of valproate in the treatment of mentally retarded persons with typical and atypical bipolar disorders.

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Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay

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Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington’s disease mutation

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Lithium‐induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N‐methyl‐ D ‐aspartate receptor‐mediated excitotoxicity

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Multiple Roles for Glycogen Synthase Kinase-3 as a Drug Target in Alzheimers Disease

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Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice

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Chronic lithium treatment magnifies learning in rats

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Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils

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Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis

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Acetylcholinesterase-amyloid-β-peptide interaction and Wnt signaling involvement in Aβ neurotoxicity

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Tau Phosphorylation and Cleavage in Ethanol-Induced Neurodegeneration in the Developing Mouse Brain

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Valproic Acid in Epilepsy

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Regulation of Neurogenesis and Angiogenesis in Depression

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Opposed effects of lithium on the MEK‐ERK pathway in neural cells: inhibition in astrocytes and stimulation in neurons by GSK3 independent mechanisms

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Survival motor neuron deficiency enhances progression in an amyotrophic lateral sclerosis mouse model

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Treatment with valproic acid ameliorates ADHD symptoms in fragile X syndrome boys

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Comparative analysis of the effects of four mood stabilizers in SH‐SY5Y cells and in primary neurons

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Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: Examining a more efficient trial design

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Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway

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Expression of Concern: Lithium inhibits Aβ‐induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation

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Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

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Lithium-Mediated Phosphorylation of Glycogen Synthase Kinase-3b Involves PI3 Kinase-Dependent Activation of Protein Kinase C-α

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Lithium reduced N-methyl-d-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia

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Glycogen Synthase Kinase-3: A Promising Therapeutic Target for Fragile X Syndrome

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Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord

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Lithium protects against oxidative stress‐mediated cell death in α‐synuclein‐overexpressing in vitro and in vivo models of Parkinson's disease

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Phosphorylation of tau by glycogen synthase kinase 3β in intact mammalian cells influences the stability of microtubules

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Lithium protects ethanol-induced neuronal apoptosis.

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Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome

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Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase γ ( POLG1 )

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Linking Alterations in Tau Phosphorylation and Cleavage during Neuronal Apoptosis

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Dose-dependent improvement of myoclonic hyperkinesia due to Valproic acid in eight Huntington's Disease patients: a case series

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Age-dependent cognitive impairment in a Drosophila Fragile X model and its pharmacological rescue

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Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease

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Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder

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Inhibition of glycogen synthase kinase-3β downregulates total tau proteins in cultured neurons and its reversal by the blockade of protein phosphatase-2A

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Histone deacetylase inhibitors sodium butyrate and valproic acid delay spontaneous cell death in purified rat retinal ganglion cells.

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A Double Blind Trial of Lithium Carbonate and Haloperidol in Huntington's Chorea

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Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study

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The lithiumeter: a measured approach

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TRPM2 variants and bipolar disorder risk: confirmation in a family‐based association study

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Molecular diagnosis of non-deletion SMA patients using quantitative PCR of SMN exon 7

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Mood-Stabilizers Target the Brain Arachidonic Acid Cascade

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Drug treatment for mood disorders in pregnancy

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SMN1 gene duplications are associated with sporadic ALS

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Increased expression of endoplasmic reticulum stress proteins following chronic valproate treatment of rat C6 glioma cells

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Valproic Acid Regulates Antioxidant Enzymes and Prevents Ischemia/Reperfusion Injury in the Rat Retina

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Valproate reduces tau phosphorylation via cyclin-dependent kinase 5 and glycogen synthase kinase 3 signaling pathways

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Establishing a standardized therapeutic testing protocol for spinal muscular atrophy

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Serum Brain-Derived Neurotrophic Factor in Euthymic Bipolar Patients on Prophylactic Lithium Therapy

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