A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans
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Abstract
Comparative transcriptomics of olfactory mucosae offers clues into the putative functions of highly abundant ORs in mammals.
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Bulk RNA-Seq of whole olfactory mucosa from macaque, marmoset, and human shows expression of almost all CoV-entry-related genes in all samples.
“we queried previously published bulk RNA-Seq data derived from the whole olfactory mucosa (WOM) of macaque, marmoset and human (43), and found expression of almost all CoV-entry-related genes in all WOM samples (Figure S1A).”
From Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia (2020) · cites this paper as [43]
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- Authors
- Saraiva, L. R., Riveros-McKay, F., Mezzavilla, M., Abou-Moussa, E. H., Arayata, C. J., Makhlouf, M., Trimmer, C., Ibarra-Soria, X., Khan, M., Van Gerven, L., Jorissen, M., Gibbs, M., O’Flynn, C., McGrane, S., Mombaerts, P., Marioni, J. C., Mainland, J. D., & Logan, D. W.
- Affiliations
- Sidra Medicine, PO Box 26999, Doha, Qatar.
- Wellcome Sanger Institute (GB)
- Sidra Medical and Research Center (QA)
- Monell Chemical Senses Center (US)
- Max Planck Research Unit for Neurogenetics (DE)
- Department of ENT-HNS, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.
- Universitair Ziekenhuis Leuven (BE)
- Waltham Centre for Pet Nutrition (GB)
- Waltham Centre for Pet Nutrition, Leicestershire LE14 4RT, UK.
- European Bioinformatics Institute (GB)
- Corresponding author
- Logan, Darren W.
- ORCID
- Venue
- Science Advances
- Published
- 2019-07-05
- Volume
- 5
- Issue
- 7
- Pages
- eaax0396-eaax0396
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC6669018
- OpenAlex
- W2966245357
- Cited by
- 92
- References
- 63
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 10 · 2023: 7 · 2022: 11 · 2021: 17 · 2020: 16
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Science Advances (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc)
- Apollo (cc-by)
- Funders
- Wellcome Trust (Grant No. 098051)
- EMBO Young Investigator Programme
- Sidra Medicine
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- olfactory epithelium, olfactory sensory neurons, semiochemicals, transcriptome, mice, rats, dogs, marmoset, macaque, human
- MeSH terms
- Animals, Biological Evolution, Food, Humans, Ligands, Male, Mammals, Odorants, Olfactory Mucosa, Olfactory Receptor Neurons, Receptors, Odorant, Gene Expression Profiling, Transcriptome
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