High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
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CD38 expression is associated with neuroinflammation with greater amounts of proinflammatory macrophages/microglia in mouse brains.
“CD38 expression was associated with neuroinflammation with greater amounts of proinflammatory macrophages/microglia in mouse brains160,165.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [160]
CD38 expression increases in the course of Alzheimer disease progression.
“CD38 expression increases in the course of Alzheimer disease progression159–161”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [160]
On the basis of high-parameter mass cytometry and single-cell RNA-sequencing studies, the dural macrophages appear to be distinct from those residing in the pia and underlying parenchyma.
“On the basis of high-parameter mass cytometry and single-cell RNA-sequencing studies, the dural macrophages appear to be distinct from those residing in the pia and underlying parenchyma (73, 94).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [94]
Microglial functions vary across different ages, disease pathologies, and between sexes.
“In addition, microglial functions vary across different ages, disease pathologies, and between sexes10–16.”
From Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies (2022) · cites this paper as [12]
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Self-citationMonocyte mobilisation, microbiota & mental illness
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“It is suggested that CAM subsets are implicated in scavenging cellular debris, pathogens, and molecules (Mrdjen et al , 2018; Kierdorf et al , 2019).”
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“One of the most striking changes in the aged brain is a ten-fold increase in T cell frequency (Mrdjen et al., 2018).”
BackgroundThe gut–meningeal immune axis: Priming brain defense against the most likely invaders
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“A number of studies have described the presence of innate and adaptive immune cells in the meninges (Mrdjen et al., 2018; Van Hove et al., 2019), and the importance of defining their number, nature, and function lies in their proximity to the brain and their potential to influence brain cell activity and health in hom…”
Background
- Authors
- Mrdjen, D., Pavlovic, A., Hartmann, F. J., Schreiner, B., Utz, S. G., Leung, B. P., Lelios, I., Heppner, F. L., Kipnis, J., Merkler, D., Greter, M., & Becher, B.
- Affiliations
- University of Zurich (CH)
- Charité – Universitätsmedizin Berlin (DE)
- University of Virginia (US)
- University of Geneva (CH)
- Corresponding author
- Becher, Burkhard
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 48
- Issue
- 3
- Pages
- 599
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W3091919022
- Cited by
- 220
- References
- 0
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 32 · 2023: 23 · 2022: 31 · 2021: 34 · 2020: 28 · 2019: 19 · 2018: 21
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- myeloid cell subsets, aging, Alzheimer's disease, multiple sclerosis, experimental autoimmune encephalitis, APP/PS1 mice, fate mapping, single-cell cytometry, mass cytometry
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