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Extreme Diversity, Conservation, and Convergence of Spider Silk Fibroin Sequences
Abstract
Spiders (Araneae) spin high-performance silks from liquid fibroin proteins. Fibroin sequences from basal spider lineages reveal mosaics of amino acid motifs that differ radically from previously described spider silk sequences. The silk fibers of Araneae are constructed from many protein designs. Yet, the repetitive sequences of fibroins from orb-weaving spiders have been maintained, presumably by stabilizing selection, over 125 million years of evolutionary history. The retention of these conserved motifs since the Mesozoic and their convergent evolution in other structural superproteins imply that these sequences are central to understanding the exceptional mechanical properties of orb weaver silks.
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Cited by
Liu, S., Yu, J.-M., Gan, Y.-C., Qiu, X.-Z., Gao, Z.-C., Wang, H., Chen, S.-X., Xiong, Y., Liu, G.-H., Lin, S.-E., et al. (2023) · Military Medical Research · doi:10.1186/s40779-023-00448-w · Cited by 357
Multicomponent nature underlies the extraordinary mechanical properties of spider dragline silk
Kono, N., Nakamura, H., Mori, M., Yoshida, Y., Ohtoshi, R., Malay, A. D., Pedrazzoli Moran, D. A., Tomita, M., Numata, K., & Arakawa, K. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107065118 · Cited by 99
Healable thermoset polymer composite embedded with stimuli-responsive fibres
Li, G., Meng, H., & Hu, J. (2012) · Journal of The Royal Society Interface · doi:10.1098/rsif.2012.0409 · Cited by 96
Protein genes in repetitive sequence—antifreeze glycoproteins in Atlantic cod genome
Zhuang, X., Yang, C., Fevolden, S.-E., & Cheng, C.-H. C. (2012) · BMC Genomics · doi:10.1186/1471-2164-13-293 · Cited by 12
Metadata
- Authors
- Gatesy, J., Hayashi, C., Motriuk, D., Woods, J., & Lewis, R.
- Venue
- Science
- Published
- 2001-03-30
- Volume
- 291
- Issue
- 5513
- Pages
- 2603-2605
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000550628
- Cited by
- 524
- References
- 0
- FWCI
- 10.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gatesy, J., Hayashi, C., Motriuk, D., Woods, J., & Lewis, R. (2001). Extreme Diversity, Conservation, and Convergence of Spider Silk Fibroin Sequences. Science. https://doi.org/10.1126/science.1057561
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