The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Abstract
Many intracellular pathogens infect a broad range of host tissues, but the importance of T cells for immunity in these sites is unclear because most of our understanding of antimicrobial T cell responses comes from analyses of lymphoid tissue. Here, we show that in response to viral or bacterial infection, antigen-specific CD8 T cells migrated to nonlymphoid tissues and were present as long-lived memory cells. Strikingly, CD8 memory T cells isolated from nonlymphoid tissues exhibited effector levels of lytic activity directly ex vivo, in contrast to their splenic counterparts. These results point to the existence of a population of extralymphoid effector memory T cells poised for immediate response to infection.
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“Tissue-resident memory (T RM ) cells are the most recently identified subset of memory T cells, initially characterized as effector memory T cells with a preference for residing in nonlymphoid tissues. 287-289”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [287]
Citations
Cites
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Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
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Cited by
Sorted by citations
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity
Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,119
“These cells therefore preferentially migrate between the blood and spleen compartments and enter peripheral organs, such as the lung, liver, intestinal tract, and kidney (191, 192).”
BackgroundEffector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Lineage relationship and protective immunity of memory CD8 T cell subsets
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Self-citationAdaptive Immune Features of Natural Killer Cells
Sun, J. C., Beilke, J., & Lanier, L. (2009) · Nature · doi:10.1038/nature07665 · Cited by 1,647
Metadata
- Authors
- Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L.
- Affiliations
- UConn Health (US)
- Division of Immunology, Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA.
- Venue
- Science
- Published
- 2001-03-23
- Volume
- 291
- Issue
- 5512
- Pages
- 2413-2417
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2081097093
- Cited by
- 1,952
- References
- 0
- Citations by year
- 2026: 23 · 2025: 42 · 2024: 39 · 2023: 36 · 2022: 52 · 2021: 55 · 2020: 67 · 2019: 71 · 2018: 76 · 2017: 65 · 2016: 52 · 2015: 53 · 2014: 69 · 2013: 80 · 2012: 60
- FWCI
- 42.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI41576, T32 AI 07080, R01AI041576, T32AI007080)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK45260, R01DK045260)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- effector memory T cells, non-lymphoid tissues, CD8+ T cells, T cell migration, intracellular pathogens, viral infection, bacterial infection, lytic activity
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Flow Cytometry, H-2 Antigens, Immunologic Memory, Intestine, Small, Listeriosis, Listeria monocytogenes, Liver, Lung, Lymphocyte Activation, Lymphoid Tissue, Mice, Inbred C57BL, Ovalbumin, Phenotype, Vesicular stomatitis Indiana virus, T-Lymphocyte Subsets, Rhabdoviridae Infections, CD8-Positive T-Lymphocytes, Mice
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