The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
What If There Are Only 30,000 Human Genes?
Abstract
The complete assembly of the entire human genome sequence by Venter et al. confirms recent estimates that the total number of human protein coding genes might be less than 30,000--a mere one-third increase over the nematode Caenorhabditis elegans. Such a low gene number constitutes a paradigm change, which could drastically modify our understanding of organism complexity and evolution, as well as our current interpretation of transcriptome analyses. It may also have severe consequences on the long-term sustainability of the biomedical industry in the postgenomic era.
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Cites
The sequence of the human genome
Venter, J. C., Adams, M. D., Myers, E. W., Li, P. W., Mural, R. J., Sutton, G. G., Smith, H. O., Yandell, M., Evans, C. A., Holt, R. A., et al. (2001) · Science · doi:10.1126/science.1058040 · Cited by 13,909
Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid
WATSON, J. D., & CRICK, F. H. C. (1953) · Nature · doi:10.1038/171737a0 · Cited by 13,584
Cited by
Hopkins, A. L., & Groom, C. R. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd892 · Cited by 3,305
Exploring genetic interaction manifolds constructed from rich single-cell phenotypes
Norman, T. M., Horlbeck, M. A., Replogle, J. M., Ge, A. Y., Xu, A., Jost, M., Gilbert, L. A., & Weissman, J. S. (2019) · Science · doi:10.1126/science.aax4438 · Cited by 392
Synergy between sequence and size in Large-scale genomics
Gregory, T. R. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1674 · Cited by 348
What's in a genome? The C-value enigma and the evolution of eukaryotic genome content
Elliott, T. A., & Gregory, T. R. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0331 · Cited by 323
Bridging structural biology and genomics: assessing protein interaction data with known complexes
Edwards, A. M., Kus, B., Jansen, R., Greenbaum, D., Greenblatt, J., & Gerstein, M. (2002) · Trends in Genetics · doi:10.1016/s0168-9525(02)02763-4 · Cited by 276
Metadata
- Authors
- Claverie, J.-M.
- Venue
- Science
- Published
- 2001-02-16
- Volume
- 291
- Issue
- 5507
- Pages
- 1255-1257
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1714107821
- Cited by
- 335
- References
- 2
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
