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Making Sense of Eukaryotic DNA Replication Origins
Open accessAbstract
DNA replication is the process by which cells make one complete copy of their genetic information before cell division. In bacteria, readily identifiable DNA sequences constitute the start sites or origins of DNA replication. In eukaryotes, replication origins have been difficult to identify. In some systems, any DNA sequence can promote replication, but other systems require specific DNA sequences. Despite these disparities, the proteins that regulate replication are highly conserved from yeast to humans. The resolution may lie in a current model for once-per-cell-cycle regulation of eukaryotic replication that does not require defined origin sequences. This model implies that the specification of precise origins is a response to selective pressures that transcend those of once-per-cell-cycle replication, such as the coordination of replication with other chromosomal functions. Viewed in this context, the locations of origins may be an integral part of the functional organization of eukaryotic chromosomes.
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Cited by
Global Reorganization of Replication Domains During Embryonic Stem Cell Differentiation
Hiratani, I., Ryba, T., Itoh, M., Yokochi, T., Schwaiger, M., Chang, C.-W., Lyou, Y., Townes, T. M., Schübeler, D., & Gilbert, D. M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060245 · Cited by 549
Self-citationWyrick, J. J., Aparicio, J. G., Chen, T., Barnett, J. D., Jennings, E. G., Young, R. A., Bell, S. P., & Aparicio, O. M. (2001) · Science · doi:10.1126/science.1066101 · Cited by 416
The origin recognition complex: from simple origins to complex functions
Bell, S. P. (2002) · Genes & Development · doi:10.1101/gad.969602 · Cited by 288
Replication timing and transcriptional control: beyond cause and effect
Gilbert, D. M. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00326-5 · Cited by 287
Self-citationHalawa, E. M., Fadel, M., Al-Rabia, M. W., Behairy, A., Nouh, N. A., Abdo, M., Olga, R., Fericean, L., Atwa, A. M., El-Nablaway, M., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1305294 · Cited by 280
Metadata
- Authors
- Gilbert, D. M.
- Venue
- Science
- Published
- 2001-10-05
- Volume
- 294
- Issue
- 5540
- Pages
- 96-100
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087909839
- Cited by
- 314
- References
- 0
- FWCI
- 11.62
- Type
- journal article
- Language
- en
- Open access
- green
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