The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae : High-Resolution Mapping of Replication Origins
Abstract
DNA replication origins are fundamental to chromosome organization and duplication, but understanding of these elements is limited because only a small fraction of these sites have been identified in eukaryotic genomes. Origin Recognition Complex (ORC) and minichromosome maintenance (MCM) proteins form prereplicative complexes at origins of replication. Using these proteins as molecular landmarks for origins, we identified ORC- and MCM-bound sites throughout the yeast genome. Four hundred twenty-nine sites in the yeast genome were predicted to contain replication origins, and ∼80% of the loci identified on chromosome X demonstrated origin function. A substantial fraction of the predicted origins are associated with repetitive DNA sequences, including subtelomeric elements (X and Y') and transposable element–associated sequences (long terminal repeats). These findings identify the global set of yeast replication origins and open avenues of investigation into the role(s) ORC and MCM proteins play in chromosomal architecture and dynamics.
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Spellman, P. T., Sherlock, G., Zhang, M. Q., Iyer, V. R., Anders, K., Eisen, M. B., Brown, P. O., Botstein, D., & Futcher, B. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3273 · Cited by 4,722
DNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,060
Self-citationGenome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N., Kanin, E., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,766
Self-citationATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex
Bell, S. P., & Stillman, B. (1992) · Nature · doi:10.1038/357128a0 · Cited by 1,269
Self-citationReplication Dynamics of the Yeast Genome
Raghuraman, M. K., Winzeler, E. A., Collingwood, D., Hunt, S., Wodicka, L., Conway, A., Lockhart, D. J., Davis, R. W., Brewer, B. J., & Fangman, W. L. (2001) · Science · doi:10.1126/science.294.5540.115 · Cited by 793
Isolation and characterisation of a yeast chromosomal replicator
Stinchcomb, D. T., Struhl, K., & Davis, R. W. (1979) · Nature · doi:10.1038/282039a0 · Cited by 771
A Yeast Chromosomal Origin of DNA Replication Defined by Multiple Functional Elements
Marahrens, Y., & Stillman, B. (1992) · Science · doi:10.1126/science.1536007 · Cited by 638
Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes
Pak, D. T. S., Pflumm, M., Chesnokov, I., Huang, D. W., Kellum, R., Marr, J., Romanowski, P., & Botchan, M. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80415-8 · Cited by 408
Regulation of Chromosome Replication
Kelly, T. J., & Brown, G. W. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.829 · Cited by 401
Making Sense of Eukaryotic DNA Replication Origins
Gilbert, D. M. (2001) · Science · doi:10.1126/science.1061724 · Cited by 314
Cited by
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
Self-citationDNA Replication in Eukaryotic Cells
Bell, S. P., & Dutta, A. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135425 · Cited by 2,060
Self-citationE2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints
Ren, B., Cam, H., Takahashi, Y., Volkert, T., Terragni, J., Young, R. A., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.949802 · Cited by 1,125
Self-citationDot1p Modulates Silencing in Yeast by Methylation of the Nucleosome Core
van Leeuwen, F., Gafken, P. R., & Gottschling, D. E. (2002) · Cell · doi:10.1016/s0092-8674(02)00759-6 · Cited by 853
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Metadata
- Authors
- Wyrick, J. J., Aparicio, J. G., Chen, T., Barnett, J. D., Jennings, E. G., Young, R. A., Bell, S. P., & Aparicio, O. M.
- Venue
- Science
- Published
- 2001-12-14
- Volume
- 294
- Issue
- 5550
- Pages
- 2357-2360
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993623149
- Cited by
- 416
- References
- 20
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wyrick, J. J., Aparicio, J. G., Chen, T., Barnett, J. D., Jennings, E. G., Young, R. A., Bell, S. P., & Aparicio, O. M. (2001). Genome-Wide Distribution of ORC and MCM Proteins in S. cerevisiae : High-Resolution Mapping of Replication Origins. Science. https://doi.org/10.1126/science.1066101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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