The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies
Abstract
Variant Creutzfeldt-Jakob disease and bovine spongiform encephalopathy are initiated by extracerebral exposure to prions. Although prion transmission from extracerebral sites to the brain represents a potential target for prophylaxis, attempts at vaccination have been limited by the poor immunogenicity of prion proteins. To circumvent this, we expressed an anti-prion protein (anti-PrP) μ chain in Prnp o/o mice. Transgenic mice developed sustained anti-PrP titers, which were not suppressed by introduction of Prnp + alleles. Transgene expression prevented pathogenesis of prions introduced by intraperitoneal injection in the spleen and brain. Expression of endogenous PrP (PrP C ) in the spleen and brain was unaffected, suggesting that immunity was responsible for protection. This indicates the feasibility of immunological inhibition of prion disease in vivo.
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Cites
Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
Collinge, J., Sidle, K. C. L., Meads, J., Ironside, J., & Hill, A. F. (1996) · Nature · doi:10.1038/383685a0 · Cited by 1,735
Cited by
Therapeutic approaches to protein-misfolding diseases
Cohen, F. E., & Kelly, J. W. (2003) · Nature · doi:10.1038/nature02265 · Cited by 800
Experimental autoimmune encephalomyelitis repressed by microglial paralysis
Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., et al. (2005) · Nature Medicine · doi:10.1038/nm1177 · Cited by 732
Self-citationHeikenwalder, M., Polymenidou, M., Junt, T., Sigurdson, C., Wagner, H., Akira, S., Zinkernagel, R., & Aguzzi, A. (2004) · Nature Medicine · doi:10.1038/nm987 · Cited by 449
Self-citationNeuroinflammation in Alzheimer's disease and prion disease
Eikelenboom, P., Bate, C., Van Gool, W. A., Hoozemans, J. J. M., Rozemuller, J. M., Veerhuis, R., & Williams, A. (2002) · Glia · doi:10.1002/glia.10146 · Cited by 405
Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo
Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sánchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., et al. (2004) · Science · doi:10.1126/science.1094273 · Cited by 366
Metadata
- Authors
- Heppner, F. L., Musahl, C., Arrighi, I., Klein, M. A., Rülicke, T., Oesch, B., Zinkernagel, R. M., Kalinke, U., & Aguzzi, A.
- Venue
- Science
- Published
- 2001-10-05
- Volume
- 294
- Issue
- 5540
- Pages
- 178-182
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993820504
- Cited by
- 346
- References
- 1
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heppner, F. L., Musahl, C., Arrighi, I., Klein, M. A., Rülicke, T., Oesch, B., Zinkernagel, R. M., Kalinke, U., & Aguzzi, A. (2001). Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies. Science. https://doi.org/10.1126/science.1063093
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